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Process for preparing high-permeability antibacterial wound dressing by jet cavitation

A technology of wound dressing and gas permeability, which is applied in the field of new polysaccharide-plant alkaloid processing, and can solve the problems of poor gas permeability and antibacterial properties

Inactive Publication Date: 2019-03-29
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The problem to be solved by the present invention is to improve the defects of poor air permeability and bacteriostatic properties of existing wound dressings, and provide a process for preparing highly air-permeable antibacterial wound dressings by jet cavitation, which has good biocompatibility and conforms to the concept of environmental protection. , medical products that promote wound healing

Method used

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  • Process for preparing high-permeability antibacterial wound dressing by jet cavitation
  • Process for preparing high-permeability antibacterial wound dressing by jet cavitation

Examples

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Effect test

Embodiment 1

[0016] A kind of jet cavitation prepares the technology of highly air-permeable antibacterial wound dressing, it is characterized in that the method comprises the following steps: (1) take certain quality commercial chitosan and be dissolved in 1% acetic acid solution, be configured to 0.05g / mL chitosan solution, then add 0.1 capsaicin (in terms of 1mL chitosan solution) to the solution to configure capsaicin-chitosan solution; (2) use glycerol as plasticizer by 6% Add the ratio to the capsaicin-chitosan solution to obtain the chitosan-capsaicin mixed film preparation solution; (3) carry out jet cavitation treatment to the above-mentioned chitosan-capsaicin mixed film preparation solution to obtain the chitosan-capsaicin mixed film preparation solution; For the capsaicin mixed film stock solution, the jet cavitation time is 2 minutes; (4) Pour the chitosan-capsaicin mixed film stock solution into a mold with a thickness of about 1.5 cm, and dry it at 30°C for 48 hours to obtain...

Embodiment 2

[0018] A kind of jet cavitation prepares the technology of highly air-permeable antibacterial wound dressing, it is characterized in that the method comprises the following steps: (1) take certain quality commercial chitosan and be dissolved in 1% acetic acid solution, be configured to 0.2g / mL Then add 0.4mg capsaicin (in terms of 1mL chitosan solution) to the solution to configure capsaicin-chitosan solution; (2) use glycerol as plasticizer by 12% The ratio is added in capsaicin-chitosan solution to obtain chitosan-capsaicin mixed film preparation solution; (3) jet cavitation treatment is carried out to above-mentioned chitosan-capsaicin mixed film preparation solution to obtain chitosan - Capsaicin mixed film stock solution, the jet cavitation time is 5 minutes; (4) Pour the chitosan-capsaicin mixed film stock solution into a mold with a thickness of about 1.5 cm, and dry at 30° C. for 48 hours to obtain a finished product.

Embodiment 3

[0020] A kind of jet cavitation prepares the technology of highly air-permeable antibacterial wound dressing, it is characterized in that the method comprises the following steps: (1) take certain quality commercial chitosan and be dissolved in 1% acetic acid solution, be configured to 0.1g / mL Then add 0.2mg capsaicin (in terms of 1mL chitosan solution) to the solution to configure capsaicin-chitosan solution; (2) use glycerol as plasticizer by 8% The ratio is added in capsaicin-chitosan solution to obtain chitosan-capsaicin mixed film preparation solution; (3) jet cavitation treatment is carried out to above-mentioned chitosan-capsaicin mixed film preparation solution to obtain chitosan - Capsaicin mixed film stock solution, the jet cavitation time is 3min; (4) Pour the chitosan-capsaicin mixed film stock solution into a mold with a thickness of about 1.5cm, and dry at 30°C for 48 hours to obtain a finished product.

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Abstract

The invention discloses a process for preparing a high-permeability antibacterial wound dressing by jet cavitation, and belongs to the technical field of novel polysaccharide-alkaloid processing. Theprocess comprises the following specific steps: (1) preparing a capsaicin-chitosan solution; (2) preparing a chitosan-capsaicin compound membrane preparation liquid; (3) preparing a chitosan-capsaicincompound membrane stock solution; and (4) performing mould reversing and drying to obtain a finished product. The method takes chitosan as a raw material, applies alkaloid and capsaicin to membrane production for the first time, and treats the chitosan-capsaicin compound membrane preparation liquid by using a jet cavitation technology to prepare the high-permeability and antibacterial compound membrane product. The product has good biocompatibility, regenerability and degradability, and accords with the sustainable development concept of environmental protection and saving.

Description

[0001] The invention belongs to the technical field of novel polysaccharide-plant alkaloid processing, and mainly relates to a process for preparing highly air-permeable antibacterial wound dressing by jet cavitation. Background technique [0002] A wound dressing is a wound dressing, a material used to cover a sore, wound or other damage. The types of wound dressings are: 1. Passive dressings (traditional dressings), which passively cover the wound and absorb exudate, providing limited protection for the wound; 2. Interactive dressings, there are various forms between the dressing and the wound. Interactions, such as absorbing exudate and toxic substances, allowing gas exchange, thereby creating an ideal environment for healing, barrier outer structure, preventing microbial invasion in the environment, preventing cross-infection of wounds, etc.; 3. Bioactive dressings ( occlusive dressing). However, the current commercially available wound dressings generally have the disadv...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0095A61L26/0066A61L26/009A61L2300/216A61L2300/412A61L2300/604C08L5/08
Inventor 王中江周艳滕飞郭增旺田甜王朝云
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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