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Matrine extracting method

An extraction method and matrine technology, applied in the field of biological extraction, can solve the problems of complex process, harmful to human body, difficult to popularize and apply, etc., and achieve the effects of low collection cost, easy operation and high extraction rate

Inactive Publication Date: 2019-04-02
周艳平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the process is complicated, and the use of toluene in the extraction is harmful to the human body, so it is difficult to popularize and apply

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A method for extracting matrine, comprising the following steps:

[0020] (1) Extraction: use a single solvent for immersion extraction, weigh 50g of wolf tooth thorn flower respectively, add 500mL of dichloromethane solvent to soak for 72h according to the ratio of material to liquid 1:10 (g:mL), collect the filtrate and filter residue after filtration; Continue soaking in 500mL solvent for 48h respectively, collect the filtrate after filtration, and combine the filtrate twice;

[0021] (2) Water precipitation to remove impurities: the filtrate obtained in step (1) is concentrated to dryness through a rotary evaporator under reduced pressure to obtain the crude extract of matrine, and 3 times the quality of water is added to the crude extract. Stand still for 12 hours, filter, and the filtrate is set aside;

[0022] (3) Vacuum concentration: the filtrate obtained in step (2) was concentrated in vacuo for 20 min at 60° C. and a vacuum degree of -0.075 MPa to obtain a c...

Embodiment 2

[0029] A method for extracting matrine, comprising the following steps:

[0030] (1) Extraction: use a single solvent for immersion extraction, weigh 50g of wolf tooth thorn flower respectively, add 500mL of dichloromethane solvent to soak for 72h according to the ratio of material to liquid 1:10 (g:mL), collect the filtrate and filter residue after filtration; Continue soaking in 500mL solvent for 48h respectively, collect the filtrate after filtration, and combine the filtrate twice;

[0031] (2) Water precipitation to remove impurities: the filtrate obtained in step (1) is concentrated to dryness through a rotary evaporator under reduced pressure to obtain the crude extract of matrine, and 5 times the quality of water is added to the crude extract. Stand still for 12 hours, filter, and the filtrate is set aside;

[0032] (3) Vacuum concentration: the filtrate obtained in step (2) was concentrated in vacuo for 20 minutes at 60° C. and a vacuum degree of -0.075 MPa to obtain...

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PUM

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Abstract

The invention relates to a matrine extracting method, which comprises: extracting Sophora viciifolia as a raw material, carrying out water precipitation and impurity removing, vacuum concentrating andvacuum drying to obtain a powdery matrine crude product, separating with a silica gel column, crystallizing with diethyl ether, re-crystallizing with acetone, and drying to obtain the matrine finished product. According to the present invention, the process has advantages of simple operation, high extraction rate and high product purity.

Description

technical field [0001] The invention belongs to the technical field of biological extraction, and in particular relates to a method for extracting matrine. Background technique [0002] Spike thorn, also known as white thorn flower, is a perennial shrub of the genus Sophora genus Fabaceae. It mostly grows in sunny slopes or river valleys at an altitude of 400-1500m. It is widely distributed in North China, Jiangsu, Zhejiang, Hubei, Henan, Shaanxi, Gansu and Southwest China. Wait for the province. The roots, stems, leaves, flowers, fruits and seeds of wolf tooth thorn contain alkaloids, including oxymatrine, matrine, sophoridine and other alkaloids. Wolf tooth thorn is widely used as a kind of folk medicine. Matrine is the main active ingredient of Chinese herbal medicine. Anti-asthma, anti-arrhythmia and other effects, it is an important raw material for the development of various human medicines, cleaning products and insecticidal bio-pesticides. Spike thorn seeds mainly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/22
CPCC07D471/22
Inventor 周艳平
Owner 周艳平
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