Preparation method of radix salviae miltiorrhizae extracts and application thereof to acne removal

A technology of extract and salvia miltiorrhiza, applied in the field of preparation of salvia miltiorrhiza extract, to achieve the effect of controlling the strong secretion of sebum

Inactive Publication Date: 2019-04-05
广州诗美化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report on the combination of salvia polysaccharides, salvianolic acid and total tanshinone in Danshen for acne-removing cosmetics

Method used

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  • Preparation method of radix salviae miltiorrhizae extracts and application thereof to acne removal
  • Preparation method of radix salviae miltiorrhizae extracts and application thereof to acne removal
  • Preparation method of radix salviae miltiorrhizae extracts and application thereof to acne removal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] 1 kg of Danshen medicinal material was crushed into 10 mesh powder, 20 kg of 80% (weight percentage) ethanol solution adjusted to pH 12 by 10% (w / w) sodium bicarbonate solution was added, and reflux extraction was carried out at 90° C. for 2 hours. After the extract was placed at room temperature, the dregs were removed to obtain the initial extract; then the initial extract was adjusted to a pH value of 6 with 5% (w / w) hydrochloric acid solution, left to stand for 8 hours to remove the precipitate, and then a 3000Da super The filter membrane removes macromolecular substances such as tannin, protein and pectin under the condition of 0.35Mpa, and the obtained ultrafiltrate is the extract of Danshen with anti-acne effect.

Embodiment 2

[0076] 1 kg of Danshen medicinal material was crushed into 80 mesh powder, 15 kg of 50% (weight percent) ethanol solution adjusted to pH 11 by 10% (w / w) sodium hydroxide solution was added, heated and refluxed at 100° C. for extraction twice, 1.5 hours / time, each time with 20kg of 50% (w / w) ethanol solution, the combined extract was placed at room temperature and then centrifuged to remove the medicinal residues to obtain the initial extract; then the initial extract was mixed with 5% (w / w) The pH value of the citric acid solution was adjusted to 6, and the precipitate was removed by centrifugation after standing for 8 hours. The centrifuged liquid passed through a 5000 Da ultrafiltration membrane, and the obtained ultrafiltrate was the Danshen extract with acne-removing effect.

Embodiment 3

[0078] 1 kg of Danshen medicinal material is crushed into 120 mesh powder, 10 kg of 80% (weight percentage) ethanol solution is added, and after stirring at room temperature for 24 hours, the dregs are separated and removed, and the dregs are added to adjust the pH value through 5% (w / w) sodium hydroxide solution 10kg of 50% (w / w) ethanol solution to 13, centrifuged to remove medicinal residues after heating and stirring for 1 hour at 80°C, combined two extracts to obtain the initial extract; then the initial extract was treated with 1% (w / w) ) citric acid solution to adjust the pH value to 7, and centrifuge to remove the precipitate after standing for 24 hours. The centrifugate passes through a 10000Da ultrafiltration membrane, and the obtained ultrafiltrate is the Danshen extract with acne-removing effect.

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Abstract

The invention discloses a preparation method of radix salviae miltiorrhizae extracts and application thereof to acne removal. The method comprises the following steps of (1) crushing radix salviae miltiorrhizae to obtain radix salviae miltiorrhizae powder; (2) regulating the pH value of an ethanol solution with the weight percent being 50 to 80 percent into a basic state to obtain a basic ethanolsolution; (3) adding the basic ethanol solution obtained in step (2) into radix salviae miltiorrhizae powder obtained in step (1) for extraction; obtaining primary extraction liquid; regulating the pHvalue of the primary extraction liquid to an acidic state; performing standing and centrifugation to obtain centrifugation liquid; performing ultrafiltration on centrifugation liquid by an ultrafiltration film to obtain radix salviae miltiorrhizae extracts. The method is simple; the implementation is easy; the conditions can be easily controlled; the raw material utilization rate is high; the radix salviae miltiorrhizae extracts obtained through extraction by the method can simultaneously contain salvianolic acids, salvia polysaccharide and tanshinone; the acne due to exuberant sebaceous secretion can be effectively controlled, so that the radix salviae miltiorrhizae extracts can be applied to acne removal cosmetics.

Description

technical field [0001] The invention belongs to the field of cosmetic applications, in particular to a preparation method of a salvia miltiorrhiza extract and its application in acne treatment. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge., a plant of the Labiatae family. It is distributed in most parts of the country. It is excavated in spring and autumn, and the sediment is removed, and it can be dried. It has the effects of promoting blood circulation and removing blood stasis, promoting menstrual flow and relieving pain, clearing away heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. There are three main components of salvia miltiorrhiza: water-soluble salvia polysaccharides, salvianolic acid and fat-soluble tanshinone. In the daily chemical industry, the main research is salvianolic acid and tanshinone. Use the effect of promoting blood circulation and removing blood stasis of Da...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00A61K36/537A61P17/02A61P17/10A61P31/04
CPCA61K36/537A61K2236/15A61K2236/333A61K2236/53A61Q19/00A61K8/9789A61P17/02A61P17/10A61P31/04
Inventor 刘明富
Owner 广州诗美化妆品有限公司
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