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The preparation method of oleic acid glycoside-7-ethyl-11-methyl ester

A technology of methyl ester and ethyl acetate, applied in the preparation of sugar derivatives, chemical instruments and methods, medical preparations containing active ingredients, etc., can solve problems such as infertility

Active Publication Date: 2021-09-03
WUYI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Activity screened out the aerial parts of frangipani, and found that oleacein is a strong angiotensin-converting enzyme inhibitor, which has a long-lasting antihypertensive effect on cats, dogs and rats; Post-touch inhibition and cAMP have analgesic and antispasmodic effects on the isolated ileum of guinea pigs and isolated uterus of rats; in terms of anti-fertility, the researchers extracted water from frangipani flower buds and administered orally to female rats at different doses, and the results had Significant anti-implantation effect, and showed a dose-related effect, but no effect on complete infertility

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  • The preparation method of oleic acid glycoside-7-ethyl-11-methyl ester
  • The preparation method of oleic acid glycoside-7-ethyl-11-methyl ester
  • The preparation method of oleic acid glycoside-7-ethyl-11-methyl ester

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Embodiment 1

[0031] Weigh 500g of dried jasmine needles, crush them, add ethanol with a volume fraction of 95%, put them in an 80°C water bath for extraction, filter every 2h, extract 3 times in total, combine the extracts, and use a rotary evaporator to concentrate the extracts to nothing. Alcoholic, to obtain ethanol extract. After the ethanol extract was dissolved and suspended in distilled water, it was extracted with petroleum ether, ethyl acetate and water-saturated n-butanol to obtain petroleum ether layer, ethyl acetate layer, n-butanol layer and water layer, respectively. Petroleum ether layer, acetic acid The ethyl ester layer and n-butanol layer were concentrated to no solvent with a rotary evaporator. The gained extract is weighed after vacuum-drying, obtains 14.7g, 23.3g, 28.3g respectively, then dry box preserves.

[0032] Dissolve 23.3g of the ethyl acetate layer extract with dichloromethane:methanol in any ratio, and mix evenly with 46g of 100-200 mesh silica gel. Silica ...

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Abstract

The present invention relates to isolating oleoside-7-ethyl-11-methyl ester (Oleoside-7-ethyl-11-methyl ester) from jasmine plants, and provides a method for preparing drugs for promoting osteoblast proliferation use. The present invention also provides a method for preparing oleoside-7-ethyl-11-methyl ester (Oleoside-7-ethyl-11-methyl ester), and the present invention is of great significance for the effective development and utilization of jasmine needles.

Description

technical field [0001] The invention relates to the fields of medicine and traditional Chinese medicine chemistry, in particular to a preparation method of compound oleoside-7-ethyl-11-methyl ester (Oleoside-7-ethyl-11-methyl ester). Background technique [0002] Jasminum officinale L.var.grandiflorum, also known as Jasminum officinale L.var. grandiflorum, the flower buds are shaped like arrowheads, hence the name Jasminum officinale, and it is a plant of Oleaceae. [0003] In the field of Chinese folk medicine, jasmine (jasmine) plants occupy a place and have a wide range of applications. In the early stage, domestic and foreign scholars isolated terpenoids, flavonoids and phenylpropanoids from their roots, leaves and flowers, and found that the characteristic components of Jasmine are iridoids and their glycosides. Domestic scholars have found that frangipani has the best anti-hepatitis B virus active ingredients. In addition, according to previous researches abroad, Jas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08A61P19/10A61K31/7048
CPCA61K31/7048A61P19/10C07H1/08C07H17/04
Inventor 李冬利邓智庭肖贵文唐小丹黄毅祺李慧芳吴盼盼刘文锋徐学涛张焜
Owner WUYI UNIV