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Application of ginsenoside Rg3 in preparing drug for preventing and/or treating severe acute pancreatitis

A technology of acute pancreatitis and ginsenosides, applied in the directions of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the problems such as no reports on the treatment of severe acute pancreatitis, achieve significant anti-pancreatitis, reduce positive expression, improve pathological effect of phenomenon

Inactive Publication Date: 2019-04-16
YANTAI HEMP BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies have found that ginsenoside Rg3 can be used for acute lung injury inflammation (Cheng Zhiqiang. The protective effect and mechanism of ginsenoside Rg3 on LPS-induced acute lung injury mice [D]. Zhengzhou University, 2016.) and cold inflammation (Li Gang . Anti-inflammatory and antipyretic pharmacodynamics research of ginsenoside Rg3 [D]. Jilin University, 2006.), but there is no relevant report on the treatment of severe acute pancreatitis

Method used

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  • Application of ginsenoside Rg3 in preparing drug for preventing and/or treating severe acute pancreatitis
  • Application of ginsenoside Rg3 in preparing drug for preventing and/or treating severe acute pancreatitis
  • Application of ginsenoside Rg3 in preparing drug for preventing and/or treating severe acute pancreatitis

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preparation example Construction

[0023] The present invention has no special limitation on the preparation method of the tablet, and the conventional tablet preparation method in the art can be used. During the specific implementation of the present invention, the tablet is preferably prepared by the following method:

[0024] 1) Mix ginsenoside Rg3, powdered sugar, lactose and sodium carboxymethyl starch, and sieve to obtain a fine powder;

[0025] 2) mixing the fine powder described in step 1) with a 3% PVPK30 aqueous solution by weight,

[0026] Perform granulation, drying and sizing to obtain granules;

[0027] 3) The granules described in step 2) are mixed with magnesium stearate, and compressed into tablets to obtain tablets.

[0028] In the present invention, firstly, ginsenoside Rg3, powdered sugar, lactose and sodium carboxymethyl starch are mixed and sieved to obtain fine powder; the sieve mesh aperture is preferably 80-120 mesh, more preferably 100 mesh.

[0029] After the fine powder is obtained...

Embodiment 1

[0050] The preparation of embodiment 1 ginsenoside Rg3 sheet

[0051] prescription:

[0052]

[0053]

[0054] Preparation method: Weigh the prescribed amount of ginsenoside Rg3, powdered sugar, lactose and sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add 3% PVPk30 aqueous solution to make a soft material, granulate with a 20-mesh sieve, and heat at 60°C Dry for 3 hours, sieve with 18 meshes, add the prescribed amount of magnesium stearate, mix evenly, punch tablets with dimples, adjust the tablet weight to 150 mg, and obtain the product.

Embodiment 2

[0055] The preparation of embodiment 2 ginsenoside Rg3 dropping pills

[0056] prescription:

[0057]

[0058] Preparation method: Weigh the prescribed amount of PEG400, PEG4000, sodium carboxymethyl starch, and povidone K30, add them to the dripping pill machine to melt at 95°C, add the prescribed amount of ginsenoside Rg3 while stirring, mix well, and the temperature of the drug material is 85°C, medicine material with drop distance of 20cm, press 28 drops.min -1 Drop into liquid paraffin at a specified rate, condense at 10°C, solidify, and form drop pills, then take them out and dry them to obtain the product.

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Abstract

The invention provides application of ginsenoside Rg3 in preparing a drug for preventing and / or treating severe acute pancreatitis, and belongs to the technical field of medicine. A rat severe acute pancreatitis model induced by cerulein combined with lipopolysaccharide is adopted to verify the effect of the ginsenoside Rg3 on the pathological change of pancreas and the effect of the ginsenoside Rg3 on the expression of NF-kappa B p65 and prove that the ginsenoside Rg3 can significantly improve the pathological phenomena of the rat severe acute pancreatitis and reduce the positive expression of the NF-kappa B p65. Therefore, the ginsenoside Rg3 has a remarkable anti-pancreatitis effect, and the effect is reflected in both treatment and prevention.

Description

technical field [0001] The invention relates to the technical field of prevention and treatment of severe acute pancreatitis, in particular to the application of ginsenoside Rg3 in the preparation of drugs for preventing and / or treating severe acute pancreatitis. Background technique [0002] Severe acute pancreatitis (SAP) is a clinically common severe disease with sudden onset, high fatality rate and complex and diverse pathogenesis. Activate related cells to synthesize and release a large number of inflammatory factors, such as IL-1β, TNF-α and IL-6. In order to alleviate the symptoms of inflammation and systemic poisoning, dexamethasone is often used clinically in the acute stage of severe pancreatitis for disease control, but because dexamethasone may cause complications such as gastrointestinal bleeding and immunosuppression, there are certain limitations in clinical application sex. [0003] Ginseng (Panax ginseng C.A. Mey) is a traditional Chinese herbal medicine i...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/18
CPCA61K31/704A61P1/18
Inventor 曲桂武崔明
Owner YANTAI HEMP BIOTECHNOLOGY CO LTD
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