Peppermint formula particles and preparation method thereof

A technology of formula granules and mint, which is applied in the directions of pharmaceutical formulas, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of unscientific extraction process of volatile oil, reduced efficacy and strong medicinal properties, etc. Controllable quality control standards, strong production process, no toxic and side effects

Inactive Publication Date: 2019-04-19
JIANGXI BAISHEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current volatile oil extraction process is unscientific, or it is difficult to obtain its main active ingredient volatile oil, which greatly reduces the efficacy; or the amount of volatile oil is too large, resulting in excessive medicinal properties and adverse reactions.
Its quality standard is generally the qualitative identification of menthol thin layer and the determination of volatile oil content. The specificity of this standard is limited by certain experimental conditions and scope, and there is a lack of other quality information of the product. This standard cannot fully determine the mint formula granule product. The quality and overall picture of

Method used

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  • Peppermint formula particles and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of peppermint formula granules, comprising the steps of:

[0028] S1. Take 20 parts of mint leaves, pulverize them, and sieve to obtain mint powder;

[0029] S2. Add 160 parts of water to the mint powder in step S1, and stir to obtain a mint mixture;

[0030] S3. Distill the mint mixture in step S2 at a high temperature of 175° C. for 4 hours, collect volatile oil, filter and obtain mint dregs, and set aside;

[0031] S4. Add the volatile oil in step S3 to beta-cyclodextrin and water to mix, inclusion, stir for 1.5 hours, and then put it in the refrigerator for 12 hours, wherein the mixing ratio of water is 1:8:60, and the inclusion temperature is controlled at 50°C;

[0032] S5. Filter the refrigerated liquid in step S4 with a 40-mesh sieve, dry and pulverize at low temperature to obtain a fine powder of beta-cyclodextrin inclusion complex, and set aside;

[0033] S6. Add 160 parts of water to decoct the mint dregs in step S3 for 1 hour, then fi...

Embodiment 2

[0039] A preparation method of peppermint formula granules, comprising the steps of:

[0040] S1. Take 20 parts of mint leaves, pulverize them, and sieve to obtain mint powder;

[0041] S2. Add 180 parts of water to the mint powder in step S1, and stir to obtain a mint mixture;

[0042] S3. Distill the peppermint mixture in step S2 at a high temperature of 250° C. for 3 hours, collect volatile oil, filter and obtain mint dregs, and set aside;

[0043] S4. Add the volatile oil in step S3 to beta-cyclodextrin and water to mix, inclusion, stir for 2 hours, and then put it in the refrigerator for 12 hours, wherein the mixing ratio of water is 1:8:60, and the inclusion temperature is controlled at 50°C;

[0044] S5, filter the refrigerated liquid in step S4 with a 60-mesh sieve, dry and pulverize at low temperature to obtain a fine powder of beta-cyclodextrin inclusion complex, and set aside;

[0045] S6. Add 180 parts of water to decoct the mint dregs in step S3 for 1 hour, the...

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Abstract

The invention discloses peppermint formula particles, each gram of peppermint formula particles contains 12 grams of equivalent crude drug; the content of volatile oil in the granules is between 0.6%and 1.2%. The preparation method comprises pulverizing 20 parts of Folium Menthae, and sieving to obtain Herba Menthae powder; adding water and stirring to obtain peppermint mixed solution; distillingat high temperature; collecting volatile oil; and filtering to obtain Herba Menthae residue for later use; adding beta cyclodextrin and water, mixing, encapsulating, stirring, and refrigerating in refrigerating chamber; filtering the cold storage liquid with a screen, drying and crushing at low temperature to obtain beta cyclodextrin inclusion complex fine powder for later use; decocting Herba Menthae residue with water, and filtering the decoction with screen to obtain filtrate; concentrating the filtrate to obtain fluid extract; spraying the fluid extract, and drying to obtain Herba Menthaespray powder, beta cyclodextrin inclusion fine powder and Herba Menthae spray powder, adding dextrin, mixing, and granulating to obtain Herba Menthae granule; vacuum packing and boxing.

Description

technical field [0001] The technical field of medicine extraction of the present invention, in particular, relates to a peppermint formula granule and a preparation method thereof. Background technique [0002] Mint (Mentha haplocalyx Britq) is a perennial herbaceous plant of the genus Mentha of the Labiatae family, also known as water mint, sage mint, fish herb, dandelion, sunflower, night rest flower, etc. The whole plant has a strong refreshing fragrance, and its aerial part can be used as medicine after drying, which is one of the traditional Chinese medicines in our country. [0003] Mint has a wide range of uses and can be used in medicine, food, cosmetics, spices, tobacco industry, etc. As a traditional Chinese medicine, it is pungent in taste and cool in nature. It can be used for wind-heat cold, early wind and temperature, headache, red eyes, sore throat, sore throat, sore tongue, toothache, urticaria, rubella, etc. The earliest record of mint was found in "Tang M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/69A61K36/534A61P11/00A61P29/00A61P27/02A61P11/04A61P1/02A61P17/00
CPCA61K9/1652A61K36/534A61K47/6951A61K2236/331A61K2236/39A61P1/02A61P11/00A61P11/04A61P17/00A61P27/02A61P29/00
Inventor 谭灵芝邱国旺蔡良吉小宝刘玉英
Owner JIANGXI BAISHEN PHARMA
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