Application of n-3 polyunsaturated fatty acid in preparing medicine for preventing salmonella infection

Abstract

The invention discloses an application of n-3 polyunsaturated fatty acid in preparing a medicine for preventing salmonella infection, and belongs to the field of preventing salmonella infection. According to the invention, proved by an animal model of salmonella infection, the n-3 polyunsaturated fatty acid can obviously reduce the death rate, so that the survival rate of mice infected with salmonella is improved from 56% of a control group to 75%, and the survival rate is improved by 33%. In addition, the n-3 polyunsaturated fatty acid is low in price and wide in source, is a common nutritional supplement, is safe and stable, and has great health benefits, such as prevention of cardiovascular and cerebrovascular diseases, obesity, metabolic syndrome and the like; the n-3 polyunsaturated fatty acid can be supplemented during the salmonella outbreak period, but the infection symptom does not appear, to prevent the salmonella infection or slow down the disease course, the use of antibiotics is reduced, the negative effect caused by the antibiotics is reduced, the operation is easy, and the n-3 polyunsaturated fatty acid has good application prospect.

Description

technical field [0001] The invention belongs to the field of preventing Salmonella infection, and in particular relates to the application of n-3 polyunsaturated fatty acid in preparing medicines for preventing Salmonella infection. Background technique [0002] The existing treatment mechanisms for bacterial infections are almost all through the bactericidal effect of antibiotics, and the pathogenesis of various pathogenic bacteria varies widely. For example, the toxins and toxic enzymes produced by Helicobacter pylori can destroy the gastric mucosal barrier and cause inflammation in the body and immune response, increase the secretion of gastrin, and eventually lead to chronic gastritis, peptic ulcer, gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma; exotoxin A (PEA) secreted by Pseudomonas Activated to play a toxic role, blocking protein synthesis in mammals and causing tissue necrosis, liver cell necrosis, pulmonary hemorrhage, kidney necrosis and sho...

AI Technical Summary

Problems solved by technology

For Salmonella, due to the abuse of antibiotics, its resistance to antibiotics is enhanced, and the resistance spectrum is broadened, and antibiotics may accumulate in poultry meat, affecting meat quality; antibiotic treatment can also disrupt the balance of normal intestinal flora

Salmonella usually breaks out without symptoms, and antibiotics cannot be used for treatment without a certain degree of illness. Antibiotics have their negative effects. Clinically, antibiotics are not used to prevent Salmonella infection in advance

Images