Method for catalyzing glycolide polymerization by binuclear chiral amino imine magnesium complex

A technology of amine imine magnesium and complexes, which is applied in the field of catalytic glycolide polymerization, can solve problems such as metal residues, and achieve the effects of low cost, meeting market demands, and various catalyst structure changes.

Active Publication Date: 2019-04-26
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, one problem that still needs to be solved is that there will inevitably be metal residues in the products made by metal complex catalysts, and it is almost impossible to completely remove these residues from the polymer, so low-toxicity magnesium complexes become More promising catalysts, especially when polymers are used in the field of biomedicine, such catalysts are even more important

Method used

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  • Method for catalyzing glycolide polymerization by binuclear chiral amino imine magnesium complex
  • Method for catalyzing glycolide polymerization by binuclear chiral amino imine magnesium complex
  • Method for catalyzing glycolide polymerization by binuclear chiral amino imine magnesium complex

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Effect test

Embodiment 1

[0034] The structural formula of the ligand used is the above formula (A), where R is hydrogen, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.14 g of the ligand was dissolved in 25 mL of dry toluene, and added to Mg( n Bu) 2 In the reaction mixture with benzyl alcohol, after adding, the reaction liquid was naturally raised to room temperature, and then heated to 60 ° C for 3 hours. After the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried. Weighed to obtain 3.05 g of solid, the yield was 83.4%.

Embodiment 2

[0036] The structural formula of the ligand used is the above formula (A), where R is a methyl group, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.64 g of the ligand was dissolved in 25 mL of dry toluene, and added to Mg( n Bu) 2and benzyl alcohol reaction mixture, after adding, the reaction liquid was naturally raised to room temperature, and then heated to 40 ° C for 10 hours, after the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried Weighed to obtain 3.33 g of solid, the yield was 84.5%.

Embodiment 3

[0038] The structural formula of the ligand used is the above formula (A), where R is ethyl, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.92 g of the ligand was dissolved in 30 mL of dry toluene, and added to Mg( n Bu) 2 In the reaction mixture with benzyl alcohol, after the addition, the reaction liquid was naturally raised to room temperature, and then heated to 50°C for 6 hours. After the reaction was completed, the solvent was vacuum-dried, and the residue was added to dry n-hexane to filter and washed with dry n-hexane. , the product was collected and dried and weighed to obtain 3.66 g of solid, with a yield of 86.6%.

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Abstract

The invention discloses a method for catalyzing glycolide polymerization by a binuclear chiral amino imine magnesium complex. The method comprises following steps: the binuclear chiral amino imine magnesium complex is taken as a catalyst, glycolide is taken as a raw material, glycolide polymerization is catalyzed under the anhydrous and anaerobic conditions and under protection of gas, and polyglycollide is obtained; the catalyst is the binuclear chiral amino imine magnesium complex. A glycolide ring-opening polymerization is performed by adopting own developed binuclear chiral amino imine magnesium complex as the catalyst, a preparation method of the catalyst is simple, the cost is low, the structure is diversified, metal-center magnesium coordinates with N,N atoms of ligands, catalytic activity is high, a promoter is not needed, the reaction rate is high, and a polymer has narrow molecular weight distribution and controllable molecular weight.

Description

technical field [0001] The invention relates to a method for catalyzing the polymerization of glycolide, in particular to a method for catalyzing the polymerization of glycolide by using a dinuclear chiral amine imine magnesium complex. Background technique [0002] With the enhancement of people's awareness of environmental protection, the development of degradable biomaterials that can reduce environmental pollution has become one of the important research fields of polymer materials. Polylactone is a biodegradable, green and environment-friendly polymer material, and it has attracted more and more attention as a substitute for petroleum products. In the natural living environment, waste polylactone materials can be completely decomposed into small molecules by microorganisms in the soil. Because polyester is non-toxic, non-irritating, and has good biocompatibility, it is widely used in medical and environmental protection fields, such as surgical sutures, packaging, drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/83C08G63/08
CPCC08G63/08C08G63/823
Inventor 顿爱社张春菊侯海峰王洪宾姚伟张海东于广福孙丰刚
Owner TAISHAN MEDICAL UNIV
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