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Application of polygonum cillinerve in preparing antifungal drugs and synergist thereof

The technology of an antifungal drug, cinnabar heptaol, which is applied in the field of medicine, can solve the problems such as the synergistic effect of antifungal effect of cinnabar seven, and achieve the effect of reducing the concentration of the drug

Active Publication Date: 2019-05-03
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] But at present, there is no report on the antifungal effect of cinnabar seven and its synergistic effect on antifungal drugs at home and abroad.

Method used

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  • Application of polygonum cillinerve in preparing antifungal drugs and synergist thereof
  • Application of polygonum cillinerve in preparing antifungal drugs and synergist thereof
  • Application of polygonum cillinerve in preparing antifungal drugs and synergist thereof

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Experimental program
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Effect test

Embodiment Construction

[0018] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0019] 1. Material preparation

[0020] 1. Test drug

[0021] Cinnabar VII: purchased from Chengdu Desite Biotechnology Co., Ltd., purity ≥ 99%, batch number DST170411-006.

[0022] Fluconazole (FLC)): sigma company, lot number 036M4709V.

[0023] Dimethyl sulfoxide: Tianjin Tianli Chemical Reagent Co., Ltd.

[0024] All reagents were stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.

[0025] 2. Strains

[0026] Strains used, including:

[0027] 1) Sensitive strains: sensitive Candida albicans SC5314, Candida parapsilosis 22019 and Cryptococcus neoformans 32609;

[0028] 2) Drug-resistant strains: drug-resistant Candida albicans 103, drug-resistant Candida tropicali...

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Abstract

The invention discloses an application of polygonum cillinerve in fungus resisting, and belongs to the technical field of medicine. In vitro experiments show that polygonum cillinerve has a good inhibitory effect on fungi, and can restore the effect of antifungal drug fluconazole on drug-resistant fungi. Therefore, the polygonum cillinerve can be used as an antifungal drug and a synergist of the antifungal drug. The invention opens up a new use for the polygonum cillinerve, uses the polygonum cillinerve for antifungal drugs and synergists of the antifungal drugs, not only provides s new drug candidate for fungal treatment, but also improves the antifungal action of existing drugs. In the case of the increasing prevalence of clinical fungal resistance and the increasing degree of drug resistance, the polygonum cillinerve restore the effect of antifungal drugs on drug-resistant fungi, and reduces the dosage of antifungal drugs, thereby saving medical expenses for the patient and reducingthe toxic side effect of the antifungal drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of cinnabar seven in the preparation of antifungal drugs and their synergists. Background technique [0002] Cinnabar seven (Polygonum cillinerve), also known as cinnabar lotus, red Yaozi, first recorded in "Tu Jing Materia Medica", is the tuber root of Polygonum cillinerve (Nakai) Ohwl Polygonum genus Polygonum cillinerve. Cool and flat, it has the functions of clearing heat and detoxifying, promoting blood circulation and cooling blood, stopping bleeding and stopping diarrhea, removing rheumatism, strengthening waist and knees, etc. It is one of the important "Taibai Qiyao", and has been listed as a rare authentic herbal medicine in Shaanxi by "Shaanxi Health Records". [0003] But at present, there is no report on the antifungal effect of cinnabar seven and its synergistic effect on antifungal drugs at home and abroad. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P31/10A61K125/00A61K31/4196
Inventor 刘伟孙宝政杨曼曼王胜正张子悦
Owner SHAANXI UNIV OF SCI & TECH
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