Production method of tissue compensation adhesive for cancer radiotherapy

A technology of radiotherapy and tissue compensation, which is applied in the field of medical materials, can solve the problems of difficult mixing of materials, aggravation of skin damage, and unsatisfactory adhesion between tissue compensators and skin, so as to shorten the production cycle, reduce skin damage, Facilitate the effect of mixing

Active Publication Date: 2019-05-03
杭州恒煜医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the existing tissue compensator materials are not easy to mix, and the degree of adhesion between the prepared tissue compensator and the skin is not ideal, causing high-energy rays to cause a secondary build-up effect on the skin and aggravate the skin damage. And proposed a kind of production method of tissue compensation glue for cancer radiotherapy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of production method of tissue compensation glue for cancer radiotherapy proposed by the present invention comprises the following steps:

[0019] S1. Weigh solid paraffin, low-density polyethylene, styrene-maleic anhydride copolymer and crospovidone according to the mass ratio of 100:2:12:3, and set aside, the styrene-maleic anhydride copolymer It is a styrene-maleic anhydride random copolymer with a density of 1.27g / ml at 25°C and a refractive index n20 / D of 1.581;

[0020] S2. At room temperature, mix styrene-maleic anhydride copolymer and crospovidone, and add 1,4-dioxane 20 times the mass of styrene-maleic anhydride copolymer to azeotrope for 2 hours, then Lower the temperature to 35°C at a cooling rate of 2°C / min, then drop to 10°C at a cooling rate of 1°C / min, keep it for 40 minutes after the temperature drops to 10°C, then add 0.45 times the mass of styrene-maleic anhydride copolymer Hydroxylamine hydrochloride reacted with sodium methoxide 0.4 times the...

Embodiment 2

[0023] A kind of production method of tissue compensation glue for cancer radiotherapy proposed by the present invention comprises the following steps:

[0024] S1. Weigh solid paraffin, low-density polyethylene, styrene-maleic anhydride copolymer and crospovidone according to the mass ratio of 100:2:13:5, and set aside, the styrene-maleic anhydride copolymer It is a styrene-maleic anhydride random copolymer with a density of 1.27g / ml at 25°C and a refractive index n20 / D of 1.581;

[0025] S2. At room temperature, mix styrene-maleic anhydride copolymer and crospovidone, and add 1,4-dioxane 20 times the mass of styrene-maleic anhydride copolymer to azeotrope for 1 hour, then Lower the temperature to 40°C at a cooling rate of 2°C / min, then drop to 15°C at a cooling rate of 1°C / min, keep it for 30 minutes after the temperature drops to 15°C, then add 0.47 times the mass of styrene-maleic anhydride copolymer Hydroxylamine hydrochloride reacted with sodium methoxide of 0.41 times ...

Embodiment 3

[0028] A kind of production method of tissue compensation glue for cancer radiotherapy proposed by the present invention comprises the following steps:

[0029] S1. Weigh solid paraffin, low-density polyethylene, styrene-maleic anhydride copolymer and crospovidone according to the mass ratio of 100:2:14:7, and set aside, the styrene-maleic anhydride copolymer It is a styrene-maleic anhydride random copolymer with a density of 1.27g / ml at 25°C and a refractive index n20 / D of 1.581;

[0030] S2. At room temperature, mix styrene-maleic anhydride copolymer and crospovidone, and add 1,4-dioxane 20 times the mass of styrene-maleic anhydride copolymer to azeotrope for 1 to 2 hours , first drop the temperature to 40°C at a cooling rate of 2°C / min, then drop to 20°C at a cooling rate of 1°C / min, and keep it for 30 minutes after the temperature drops to 20°C, then add the mass of styrene-maleic anhydride copolymer React 0.48 times the weight of hydroxylamine hydrochloride with 0.42 tim...

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Abstract

The invention provides a production method of tissue compensation glue for cancer radiotherapy, the preparation method comprises the following steps: 1, weighing solid paraffin, low-density polyethylene, a styrene-maleic anhydride copolymer and cross-linked povidone according to the mass ratio of 100: 2: 12-14: 3-7; S2, mixing the styrene-maleic anhydride copolymer with the cross-linked povidone,adding 1,4-dioxane for co-boiling, then cooling to 10-20 DEG C, keeping for 30-40 minutes, then adding hydroxylamine hydrochloride and sodium methoxide to react, then adding methylbenzene for co-boiling for 5 hours, filtering, washing filter residue with diethyl ether and water, and carrying out vacuum drying on the filter residue until the filter residue reaches constant weight to obtain a synergist; S3, mixing and injecting the solid paraffin, the low-density polyethylene and the synergist into a mold, and performing molding and demolding to obtain the tissue compensation adhesive for cancerradiotherapy. The production method provided by the invention has the advantages of simple operation and one-time forming, and the produced tissue compensation glue can be applied to cancer radiotherapy and is good in adhesion to skin.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a production method of tissue compensation glue for cancer radiotherapy. Background technique [0002] Cancer is a disease caused by the loss of normal regulation and excessive proliferation of body cells. Excessively proliferating cells are called cancer cells. Cancer cells can often invade surrounding tissues and even transfer to other parts of the body through the circulatory system and / or lymphatic system. Current cancer treatment methods include surgical treatment, chemotherapy, radiotherapy or a combination of several, and about 70% of cancer patients need to undergo radiotherapy during cancer treatment, so radiotherapy plays an important role in the treatment of cancer. important role. In the process of radiotherapy, after high-energy rays enter the human body, there is a dose built-up area, and the dose after the built-up area is the actual dose acting on the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J191/06C09J123/06C09J135/06C09J139/06C09J11/08
Inventor 廖敏悦陈乙肖方俊甘雨滋
Owner 杭州恒煜医疗科技有限公司
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