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Enzyme-free multi-purpose medical instrument cleaning agent, and preparation method and application thereof

A medical device and multi-purpose technology, applied in the field of cleaning agents, can solve the problems of decomposition and destruction of other protein components, short shelf life of liquid reagents, high cleaning environment requirements, etc., achieve wide reaction conditions, inhibit the growth of bacteria and viruses, Good cleaning effect

Inactive Publication Date: 2019-05-03
石华英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (1) Enzymes belong to proteins. Proteins maintain activity within a certain temperature range and pH range. The activity is the highest under the optimum temperature and optimum pH conditions, and the activity is weak or even inactive under other conditions; therefore, the enzymatic reaction requires Certain pH and temperature, etc., the reaction conditions are relatively mild, and any physical and chemical factors that denature proteins such as strong acid, strong alkali, organic solvent, high temperature, ultraviolet rays or violent shocks may cause enzyme denaturation and loss of activity. Therefore, the existing multi-enzyme cleaning agent High requirements for cleaning environment;
[0008] (2) The enzyme is in an active state in the liquid detergent and may decompose and destroy other protein components. Even the liquid reagent of a single protease has a relatively short shelf life;
[0009] (3) Enzyme is a biological agent, its extraction and preparation are cumbersome and expensive, and the price of foreign enzyme-containing cleaning solutions can reach more than 260 yuan / liter, which seriously restricts its scope of use

Method used

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  • Enzyme-free multi-purpose medical instrument cleaning agent, and preparation method and application thereof
  • Enzyme-free multi-purpose medical instrument cleaning agent, and preparation method and application thereof
  • Enzyme-free multi-purpose medical instrument cleaning agent, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The purpose of this embodiment is to provide a kind of non-enzyme multi-purpose medical instrument cleaning agent, and its preparation method is as follows:

[0046] (1) Weigh protein lysing agent 1 0.01g%, protein lysing agent 2 0.2g%, erythrocyte lysing agent 0.01g%, biological preservative 0.01g%, rust remover 0.01g%, pH 6.0-6.5 Buffer pair, added to a stirring vessel;

[0047] The buffer pair is NaH 2 PO 4 and Na 2 HPO 4 , NaH in the enzyme-free multi-purpose cleaning agent for medical instruments 2 PO 4 The weight percentage is 0.02-0.06%, and Na in the enzyme-free multipurpose cleaning agent for medical instruments 2 HPO 4 The weight percent is 0.01-0.02%;

[0048] (2) After the weighing is completed, first add an appropriate amount of ion-exchanged water to the stirring device containing protein dissolving agent 1, protein dissolving agent 2, red blood cell lysing agent, biological preservatives, rust remover and buffer pair, mix well, and then The ion-e...

Embodiment 2

[0050] The purpose of this embodiment is to provide a kind of non-enzyme multi-purpose medical instrument cleaning agent, and its preparation method is as follows:

[0051] (1) Weigh protein lysing agent 1 0.02g%, protein lysing agent 2 0.4g%, erythrocyte lysing agent 0.05g%, biological preservative 0.014g%, rust remover 0.014g%, pH 6.0-6.5 Buffer pair, added to a stirring vessel;

[0052] The buffer pair is NaH 2 PO 4 and Na 2 HPO 4 , NaH in the enzyme-free multi-purpose cleaning agent for medical instruments 2 PO 4 The weight percentage is 0.02-0.06%, and Na in the enzyme-free multipurpose cleaning agent for medical instruments 2 HPO 4 The weight percent is 0.01-0.02%;

[0053] (2) After the weighing is completed, first add an appropriate amount of ion-exchanged water to the stirring device containing protein dissolving agent 1, protein dissolving agent 2, red blood cell lysing agent, biological preservatives, rust remover and buffer pair, mix well, and then The ion...

Embodiment 3

[0055] The purpose of this embodiment is to provide a kind of non-enzyme multi-purpose medical instrument cleaning agent, and its preparation method is as follows:

[0056] (1) Weigh protein lysing agent 1 0.05g%, protein lysing agent 2 0.6g%, erythrocyte lysing agent 0.1g%, biological preservative 0.015g%, rust remover 0.015g%, pH 6.0-6.5 Buffer pair, added to a stirring vessel;

[0057] The buffer pair is NaH 2 PO 4 and Na 2 HPO 4 , NaH in the enzyme-free multi-purpose cleaning agent for medical instruments 2 PO 4 The weight percentage is 0.02-0.06%, and Na in the enzyme-free multipurpose cleaning agent for medical instruments 2 HPO 4 The weight percent is 0.01-0.02%;

[0058] (2) After the weighing is completed, first add an appropriate amount of ion-exchanged water to the stirring device containing protein dissolving agent 1, protein dissolving agent 2, red blood cell lysing agent, biological preservatives, rust remover and buffer pair, mix well, and then The ion-...

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Abstract

The invention belongs to the technical field of cleaning agents, and discloses an enzyme-free multi-purpose medical instrument cleaning agent, and a preparation method and an application thereof. Theenzyme-free cleaning agent is prepared from the following raw materials: 0.01 to 0.1 g% of a protein dissolving agent 1, 0.2 to 1 g% of a protein dissolving agent 2, 0.01 to 0.2 g% of a red blood cellcracking agent, 0.01 to 0.02 g% of a biological preservative, 0.01 to 0.02 g% of a rust remover, and a buffer pair with a pH value of 6.0 to 6.5, with the balance being ion exchange water, wherein the protein dissolving agent 1 is one or a mixture of more selected from the group consisting of amide and NaHCO3; the protein dissolving agent 2 is one or a mixture of more selected from the group consisting of dithiothreitol and cysteine; and the red blood cell cracking agent is one or a mixture of more selected from the group consisting of a cationic surfactant, an anionic surfactant and a nonionic surfactant. The invention has the following advantages: the enzyme-free multi-purpose medical instrument cleaning agent can reach the same effects as a multienzyme containing cleaning agent withoutthe use of multienzyme as a special reagent for protein dissolution, and has good consistency, wider reaction conditions, no toxic reagent, environmental friendliness, extremely-low cost, stable decontamination performance and no corrosivity.

Description

technical field [0001] The invention belongs to the technical field of cleaning agents, and in particular relates to an enzyme-free multipurpose cleaning agent for medical instruments, a preparation method and an application. Background technique [0002] During the operation, medical instruments will come into contact with the patient's body fluids and tissues, and will be contaminated with some body fluids, blood and fibrin. Before reuse, these medical devices must undergo strict handling to ensure safety. Because the instruments are stained with blood and body fluids and other contaminants, it is difficult to wash and remove them with water, and if the fibrinogen in the blood is not removed in the cleaning stage, it will be denatured in the thermodynamic disinfection stage, and the protein denaturation is difficult to be removed in the subsequent disinfection process. Therefore, it is very important to thoroughly remove these pollutants. [0003] At present, the importe...

Claims

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Application Information

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IPC IPC(8): C11D1/00C11D3/06C11D3/34C11D3/33C11D3/30C11D3/20C11D3/48C11D3/60
Inventor 石华英滕飞鹏
Owner 石华英