Chitosan hydrogel used for treating and repairing stoma skin and preparation method thereof

A technology of chitosan and chitosan, which is applied in the field of biomedical materials, can solve the problem of no curative effect of intestinal stoma, achieve the effect of increasing antibacterial and anti-inflammatory ability, easy to apply and use, and good therapeutic effect

Inactive Publication Date: 2019-05-10
武汉市思泰利医疗器械发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this composition is only effective for urostomy, and has no effect on intestinal stoma

Method used

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  • Chitosan hydrogel used for treating and repairing stoma skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Formula

[0032] The chitosan hydrogel used to treat and repair stoma skin in this embodiment consists of the following components: 70g of purified water, 5g of glycerin, 0.5g of chitosan, 0.5g of lactic acid, 10g of panthenol, and preservative phenoxyethanol 0.1g, 1g of purslane extract.

[0033] 2. Preparation method:

[0034] 2.1 Preparation of purslane extract

[0035] (1) Take 20g of purslane powder, add it into 70vol% ethanol solution according to the ratio of material to liquid of 1:10, heat and stir for extraction, and keep warm at 80°C for two hours;

[0036] (2) Filtration of the extract in step (1), adding 0.5wt% activated carbon to the filtrate, and incubating at 60°C for half an hour;

[0037] (3) The material in step (2) is centrifugally filtered to obtain a purslane extract solution; concentrated, evaporated to dry ethanol, and the concentrated solution is freeze-dried to obtain a purslane extract.

[0038] 2.2 Hydrogel Preparation

[0039] (1) Ta...

Embodiment 2

[0045] 1. Formula

[0046] The chitosan hydrogel used to treat and repair stoma skin in this embodiment consists of the following components: 75g of purified water, 8g of glycerin, 5g of chitosan, 2g of lactic acid, 5g of panthenol, and 0.5g of preservative phenoxyethanol , Purslane extract 4.5g.

[0047] 2. Preparation method:

[0048] 2.1 The preparation of purslane extract is the same as in Example 1.

[0049] 2.2 Hydrogel Preparation

[0050] (1) Take 1.7-1.9g of lactic acid and fully dissolve it in purified water to form an acid solution, dissolve glycerin in the acid solution, and fully homogenize;

[0051] (2) under continuous stirring condition, chitosan is slowly added in the solution that step (1) obtains, until dissolving completely;

[0052](3) Add preservatives, purslane extract and panthenol to the solution obtained in step (2) successively, and fully dissolve;

[0053] (4) adding the remaining lactic acid to the solution in step (3) to adjust the pH of the ...

Embodiment 3

[0056] 1. Formula

[0057] The chitosan hydrogel used to treat and repair stoma skin of the present embodiment consists of the following components: 80g of purified water, 7g of glycerin, 8g of chitosan, 5g of malic acid, 1g of panthenol, preservative polyaminopropyl Biguanide 5g, purslane extract 10g.

[0058] 2. Preparation method:

[0059] 2.1 The preparation of purslane extract is the same as in Example 1.

[0060] 2.2 Hydrogel Preparation

[0061] (1) Take 4.25-4.75g malic acid and fully dissolve in purified water to form an acid solution, dissolve glycerin in the acid solution, and fully homogenize;

[0062] (2) under continuous stirring condition, chitosan is slowly added in the solution that step (1) obtains, until dissolving completely;

[0063] (3) Add preservatives, purslane extract and panthenol to the solution obtained in step (2) successively, and fully dissolve;

[0064] (4) adding the remaining malic acid to the solution of step (3) to adjust the pH of the...

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Abstract

The invention relates to chitosan hydrogel used for treating and repairing stoma skin and a preparation method thereof. The chitosan hydrogel is composed of, by weight, 70-90 parts of purified water,5-10 parts of glycerin, 0.5-10 parts of chitosan, 0.5-5 parts of organic acid, 1-10 parts of panthenol, 0.1-5 parts of preservative and 1-10 parts of portylaca oleracea extract. The preparation methodincludes the steps that S1, by total weight, 85-95% of the organic acid in a formula is sufficiently dissolved in the purified water to form acidic liquor, glycerin is dissolved in the acidic liquor,and sufficient homogenizing is conducted; S2, under continuous stirring, chitosan is slowly added into a solution obtained in the first step until dissolving is thorough; S3, the preservation, the portylaca oleracea extract and the panthenol are added into a solution obtained in the second step, and sufficient dissolving is conducted; S4, the remaining 5-15% of organic acid is added into a solution in the third step to adjust the pH of the solution to be 5.0-6.0; S5, materials in the fourth step are separately packaged and subjected to irradiation sterilization. The chitosan hydrogel is goodin treatment effect and can effectively relieve skin inflammation of a patient with a stoma and effectively help the patient to heal when the skin of the patient with the stoma has eruptions.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a chitosan hydrogel for treating stoma skin and a preparation method thereof. Background technique [0002] The stoma is caused by diseases of the digestive system or urinary system. It is necessary to separate the intestinal tube through surgical treatment, and lead one end of the intestinal tube to the body surface (anus or urethra is moved to the abdominal wall) to form an opening to achieve intestinal decompression, Reduce obstruction, protect the anastomosis or damage of the distal intestine, promote the recovery of intestinal and urinary tract diseases, and even save the patient's life. Stomas are generally for rectal and bladder lesions (such as rectal cancer, bladder cancer, intestinal obstruction, etc.). In order to save the patient's life, the doctor surgically removes the lesion. For example, rectal cancer will remove the rectum and anal canal, and bladder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/06A61K47/36A61P17/02A61P31/02A61P31/04A61K31/164A61K31/722A61K31/785
Inventor 聂正稳周程
Owner 武汉市思泰利医疗器械发展有限公司
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