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Application of Tiger Milk Mushroom Extract in Preparation of Drugs for Treating Tumors

A tumor drug, the technology of tiger milk mushroom, is applied in the field of bioengineering to achieve the effect of large-scale production and promotion, and easy operation

Active Publication Date: 2021-09-21
FOURTH HOSPITAL OF HEBEI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the anti-tumor effect of the active ingredients of tiger milk mushroom is still being explored

Method used

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  • Application of Tiger Milk Mushroom Extract in Preparation of Drugs for Treating Tumors
  • Application of Tiger Milk Mushroom Extract in Preparation of Drugs for Treating Tumors
  • Application of Tiger Milk Mushroom Extract in Preparation of Drugs for Treating Tumors

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Effect test

Embodiment

[0044] Tiger Milk Mushroom was purchased from Fumin Edible Fungi Development Base of Jiangxi Province (Yihuang County Fumin Edible Fungi Plantation Professional Association); cancer cell A549 was obtained from the Fourth Affiliated Hospital of Hebei Medical University (the Fourth Provincial Hospital).

[0045] (1) Preparation and inoculation of liquid medium

[0046] 1. Experimental materials: 200g peeled potatoes, 20g glucose, 0.6g anhydrous magnesium sulfate, 1g potassium dihydrogen phosphate, 5.5g agar, 400μg / L sodium selenite, 1000ml distilled water.

[0047] 2. Experimental steps:

[0048] [1] Slice the potatoes and boil them in water, and cook them for about 5 minutes after boiling to obtain a mixture;

[0049][2] Take the filtrate after filtering the mixed solution, and add magnesium sulfate, potassium dihydrogen phosphate, sodium selenite, glucose and agar to the filtrate, and boil to dissolve it completely to obtain a solution;

[0050] [3] Dilute the obtained solu...

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Abstract

The invention proposes the application of tiger milk mushroom extract in the preparation of drugs for treating tumors. Experiments prove that the active ingredients of tiger milk mushroom screened by MTT method have anti-tumor activity, and the inhibition rate on lung cancer cells is above 80%. The present invention also provides a preparation method of the tiger milk mushroom extract, the method studies its fermentation conditions from the four aspects of tiger milk mushroom optimum culture temperature, growth time, shaking table speed and pH, and obtains the most suitable fermentation conditions. culture conditions, and then further use an organic solvent to extract the obtained fungal hyphae to obtain the tiger milk mushroom extract containing active ingredients. The method is easy to operate and can realize large-scale production and popularization.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to the application of a tiger milk mushroom extract in the preparation of drugs for treating tumors. Background technique [0002] Tiger Milk Mushroom (Pleurtus tuberregium), also known as Pleurtus tuberregium, Pleurtus sclerotium, Pleurtus tuckahoe, Tiger Milk Mushroom, etc., is a rare edible and medicinal fungus that grows in tropical and subtropical regions. The structure of tiger milk mushroom can be divided into two parts: mycelium and fruiting body. The mycelium exists in the matrix and has the functions of storage, decomposition and transportation. The fruiting bodies exist outside the stroma and have the functions of eating and multiplying. The sclerotias are irregular lumps, similar to round or oblate, with different sizes, and the surface is mostly yellowish-white, and a few are light yellow. When mature, the outer skin is reddish brown, and the inner part is close...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/07A61P35/00C12N1/14C12R1/645
Inventor 单保恩姚清国姚定一赵连梅张静桑梅香刘飞
Owner FOURTH HOSPITAL OF HEBEI MEDICAL UNIV