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Yinhuang chewable tablet and preparation method thereof

A chewable tablet, silver-yellow technology, applied in the field of medicine, can solve the problems of difficulty in taking ordinary tablets, drug rejection, unfavorable disease treatment, etc., and achieves the effects of convenient taking, high dissolution rate, and burden reduction.

Active Publication Date: 2019-05-21
ANHUI LIANYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for children, the elderly, and patients with dysphagia, ordinary tablets are often difficult to take, and long-term medication may even lead to psychological drug resistance, which is not conducive to the treatment of diseases

Method used

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  • Yinhuang chewable tablet and preparation method thereof
  • Yinhuang chewable tablet and preparation method thereof
  • Yinhuang chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, the preparation of honeysuckle extract

[0035] Take honeysuckle, add 10 times the amount of honeysuckle above, decoct twice, 2 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.20, then add milk of lime with a mass concentration of 20% to adjust the pH value to 10-12, let it stand still, filter the precipitate, add 4 times the amount of water of the above-mentioned precipitate, then add sulfuric acid with a volume concentration of 50% to adjust the pH value to 6-7, stir well, and keep warm at 60°C for 30 Minutes, filtered, and the filtrate was concentrated to a thick paste, dried, and obtained.

Embodiment 2

[0036] Embodiment 2, the preparation of Scutellaria baicalensis extract

[0037] Take Scutellaria baicalensis, add 10 times the amount of the above-mentioned Scutellaria baicalensis in boiling water, decoct twice, 1 hour each time, combine the decoction, filter, concentrate the filtrate to 1 / 2 of the original volume, add sulfuric acid concentrated to 50% in volume to adjust the pH value Warm at 2.60°C for 1 hour, let stand for 12 hours, filter the precipitate, wash with water until the pH value is 5, wash with ethanol with a volume concentration of 70%, and dry to obtain.

Embodiment 3

[0038] Embodiment 3, a kind of Yinhuang chewable tablet

[0039] Described Yinhuang chewable tablet is made up of following component and content thereof (making 1000):

[0040] 180g of honeysuckle extract, 60g of Scutellaria baicalensis extract, 280g of mannitol, 210g of sucrose, 3g of citric acid, 80g of magnesium stearate, 10g of silicon dioxide and 10g of stevioside; The Scutellaria baicalensis extract is the Scutellaria baicalensis extract prepared in Example 2, the particle size distribution of the magnesium stearate is D10=90 μm, D50=130 μm, D90=190 μm, and the silicon dioxide has a particle size of 20 ~30nm, specific surface area 100~200m / g, silanol number 0.5~1.0 / nm 2 of fumed silica.

[0041] Preparation:

[0042] S1 Grinding the honeysuckle extract with a jet mill to obtain honeysuckle extract particles with a particle size of 800-1000 μm;

[0043] S2 Grinding the extract of Scutellaria baicalensis with a jet mill to obtain scutellaria baicalensis extract partic...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a Yinhuang chewable tablet and a preparation method thereof. The Yinhuang chewable tablet is mainly composed of ahoneysuckle extract, a scutellaria baicalensis extract, mannitol, sucrose, citric acid, magnesium stearate, silica and stevioside. The Yinhuang chewable tablet has the advantages of good mouth feeling, high dissolution and high stability, is an ideal chewable tablet, is particularly suitable for use in children, elderly people and patients with dysphagia or poor gastrointestinal function, and canreduce the burden of drugs on gastrointestinal tracts.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a silvery yellow chewable tablet and a preparation method thereof. Background technique [0002] Pharmacological studies of honeysuckle in recent years have shown that it has antibacterial, antiviral, antipyretic, anti-inflammatory, hepatoprotective, hemostatic, anti-oxidative and immune-regulating effects. Its antibacterial and antiviral active ingredients are generally considered to be chlorogenic acid compounds. The antibacterial activity of honeysuckle water infusion is stronger than that of decoction, and the antibacterial activity of decoction is reduced after high temperature sterilization; but in addition to chlorogenic acid, flavonoids and biscetyl alcohols in honeysuckle also have strong antibacterial activity in vitro. antibacterial activity. The main active ingredient in Scutellaria baicalensis is baicalin. Pharmacodynamic studies on baicalin have shown...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/20A61K47/26A61K47/12A61K47/04A61P11/04A61P29/00A61P31/00A61P11/00
Inventor 卞学阁时文龙朱德亮徐新云
Owner ANHUI LIANYI PHARMA
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