Yinhuang chewable tablet and preparation method thereof

A chewable tablet, silver-yellow technology, applied in the field of medicine, can solve the problems of difficulty in taking ordinary tablets, drug rejection, unfavorable disease treatment, etc., and achieves the effects of convenient taking, high dissolution rate, and burden reduction.

Active Publication Date: 2019-05-21
ANHUI LIANYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for children, the elderly, and patients with dysphagia, ordinary tablets are often difficult to take, and lo

Method used

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  • Yinhuang chewable tablet and preparation method thereof
  • Yinhuang chewable tablet and preparation method thereof
  • Yinhuang chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034] Example 1. Preparation of honeysuckle extract

[0035] Take honeysuckle, add 10 times the amount of water of the above honeysuckle, decoct twice for 2 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.20, and then add 20% lime milk to adjust the pH When the value reaches 10-12, let stand, filter the precipitate, add 4 times the amount of the above precipitated water, and then add 50% sulfuric acid to adjust the pH to 6-7, stir well, and keep at 60℃ for 30 Minute, filter, concentrate the filtrate to a thick paste, dry, and get ready.

Example Embodiment

[0036] Example 2. Preparation of Scutellaria baicalensis Georgi Extract

[0037] Take Scutellaria baicalensis Georgi, add 10 times the amount of the above-mentioned Scutellaria baicalensis Georgi to boiling water, decoct twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to 1 / 2 of its original volume. Add 50% sulfuric acid concentrated to adjust the pH Incubate for 1 hour at 2,60°C, stand for 12 hours, filter the precipitate, wash with water to pH 5, wash with ethanol with a volume concentration of 70%, and dry to obtain it.

Example Embodiment

[0038] Example 3. A silver yellow chewable tablet

[0039] The Yinhuang chewable tablet consists of the following components and their contents (made into 1000 tablets):

[0040] Honeysuckle extract 180g, Scutellaria baicalensis extract 60g, mannitol 280g, sucrose 210g, citric acid 3g, magnesium stearate 80g, silicon dioxide 10g, and stevioside 10g; the honeysuckle extract is the honeysuckle extract prepared in Example 1 The scutellaria baicalensis extract is the scutellaria baicalensis extract prepared in Example 2. The particle size distribution of the magnesium stearate is D10=90μm, D50=130μm, D90=190μm, and the silica has a particle size of 20. ~30nm, the specific surface area is 100~200m / g, the number of silanol groups is 0.5~1.0 / nm 2 Fumed silica.

[0041] Preparation:

[0042] S1 The honeysuckle extract is pulverized with a jet mill to obtain honeysuckle extract particles with a particle diameter of 800-1000 μm;

[0043] S2 pulverize the scutellaria baicalensis extract with a j...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a Yinhuang chewable tablet and a preparation method thereof. The Yinhuang chewable tablet is mainly composed of ahoneysuckle extract, a scutellaria baicalensis extract, mannitol, sucrose, citric acid, magnesium stearate, silica and stevioside. The Yinhuang chewable tablet has the advantages of good mouth feeling, high dissolution and high stability, is an ideal chewable tablet, is particularly suitable for use in children, elderly people and patients with dysphagia or poor gastrointestinal function, and canreduce the burden of drugs on gastrointestinal tracts.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a silvery yellow chewable tablet and a preparation method thereof. Background technique [0002] Pharmacological studies of honeysuckle in recent years have shown that it has antibacterial, antiviral, antipyretic, anti-inflammatory, hepatoprotective, hemostatic, anti-oxidative and immune-regulating effects. Its antibacterial and antiviral active ingredients are generally considered to be chlorogenic acid compounds. The antibacterial activity of honeysuckle water infusion is stronger than that of decoction, and the antibacterial activity of decoction is reduced after high temperature sterilization; but in addition to chlorogenic acid, flavonoids and biscetyl alcohols in honeysuckle also have strong antibacterial activity in vitro. antibacterial activity. The main active ingredient in Scutellaria baicalensis is baicalin. Pharmacodynamic studies on baicalin have shown...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/20A61K47/26A61K47/12A61K47/04A61P11/04A61P29/00A61P31/00A61P11/00
Inventor 卞学阁时文龙朱德亮徐新云
Owner ANHUI LIANYI PHARMA
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