Functionalized nerve regeneration collagen scaffold, preparation method and application thereof

Abstract

The invention discloses a functionalized nerve regeneration collagen scaffold, a preparation method and an application thereof. The functionalized nerve regeneration collagen scaffold comprises: a linear, ordered collagen fiber scaffold for guiding nerve regeneration, and a CBD-SDF having collagen binding ability and combined with the collagen fiber scaffold. The functionalized nerve regenerationcollagen scaffold provided by the invention can slowly release CBD-SDF to improve the efficiency of recruiting endogenous neural stem cells, also provides a good microenvironment for cell adhesion, axon growth and elongation, and also inhibits glial scar formation. In addition, the functionalized nerve regeneration collagen scaffold with VPA are combined to promote the homing of endogenous neuralstem cells to the injury site after spinal cord injury and regulate the differentiation into neurons, promote nerve regeneration and synapse formation, inhibits of glial scar formation, and ultimatelypromotes spinal cord injury repair and motor function improvement.

Description

technical field [0001] The invention specifically relates to a biological scaffold material, in particular to a functionalized nerve regeneration collagen scaffold capable of recruiting endogenous neural stem cells, its preparation method and application in spinal cord injury repair, belonging to the technical field of biomedical materials. Background technique [0002] Spinal cord injury is an injury to the central nervous system caused by trauma or disease. After the injury occurs, a large number of neurons die, glial scars form, and nerve conduction is interrupted, resulting in impaired or lost functions below the level of injury, mainly manifested as motor function (different degrees) paralysis), urinary function, sensory conduction dysfunction. At present, clinically, only methods such as decompression and inflammation control can be used to alleviate the pain of patients, but they cannot regenerate neurons, which brings a heavy medical burden to individuals and society...

AI Technical Summary

Problems solved by technology

However, natural SDF (native SDF, NAT-SDF) diffuses and degrades too quickly in the body, which reduces its local concentration and therapeutic effect, and also produces some side effects; and most endogenous neural stem cells differentiate in the damaged microenvironment Become astrocytes and form a glial scar, which is not conducive to the survival of neurons and the growth and extension of axons

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