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3D (Three-dimensional) printing method based on micro-droplet inkjet gelation vascular stent

A vascular stent and 3D printing technology, applied in the field of 3D printing, can solve the problems of inability to accurately guarantee the material supply of the extrusion head, rough production process, and too fine printing structure, so as to save the support removal process, no support, and low cost Effect

Inactive Publication Date: 2019-05-21
HANGZHOU DIANZI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method has a rough production process, low reliability, low intelligence, discontinuous drawing and dragging of the extrusion head, can not accurately guarantee the uniform material supply of the extrusion head, and the printing structure will be too thin or too swollen.

Method used

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  • 3D (Three-dimensional) printing method based on micro-droplet inkjet gelation vascular stent
  • 3D (Three-dimensional) printing method based on micro-droplet inkjet gelation vascular stent
  • 3D (Three-dimensional) printing method based on micro-droplet inkjet gelation vascular stent

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Embodiment Construction

[0019] The present invention will be further described below in conjunction with accompanying drawing:

[0020] Such as figure 1 As shown, the present invention provides a method for 3D printing of a micro-droplet inkjet gelled vascular stent, comprising the following steps:

[0021] Step 1. Printing material preparation: The biological material used in the present invention is a mixture of sodium alginate viscous solution with a mass fraction of 1.0% and a collagen solution with a mass fraction of 0.5%, and the required mass fraction for gelation is 3.0% % calcium chloride solution. The configuration method is as follows: Sodium alginate solution configuration: use pure water, sodium alginate powder with a biochemical grade and a viscosity range of 200±20mpa·s; take the mixed phase of sodium alginate powder and purified water into a beaker and add collagen Solution, first shake it manually and then use an electromagnetic stirrer to stir at a constant speed until the sodium ...

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Abstract

The invention discloses a 3D (Three-dimensional) printing method based on a micro-droplet inkjet gelation vascular stent. The 3D printing method based on the micro-droplet inkjet gelation vascular stent comprises the following steps of: firstly preparing printing materials, wherein biological materials used are mixed liquid of a sodium alginate viscous solution and a collagen solution and a calcium chloride solution required for gelation; secondly, forming single and stable liquid droplets, then digitally producing the path, finally printing, and controlling the technological parameters of theprinting process. The 3D printing method based on the micro-droplet inkjet gelation vascular stent is simple in operation; and an inkjet type 3D printer is adopted according to the 3D printing method, has simple and standard processing instructions, and can be used for manufacturing a microstructure for cell vascularization. The method has simple process, high rate of finished products, controllable internal structure, low cost, safety and reliability, saves consumables, has no need of support, and omits the subsequent support removal process.

Description

technical field [0001] The invention belongs to the technical field of 3D printing, and relates to a method for printing biological scaffolds, in particular to a method for 3D printing of gelled vascular scaffolds based on micro-droplet inkjet. Background technique [0002] In the process of printing biological tissue, the three-dimensional micro-droplet inkjet forming process puts the bio-ink in the nozzle of the printer, and the computer controls the droplet to be printed, and the control position is printed at the specified position, and the printing continues on the basis of printing a layer. Print another layer, layer by layer to form a three-dimensional gel system, and then place it in a bioreactor to cultivate and form organs. Compared with traditional scaffold tissue engineering technology, its main advantages are: a. It can simultaneously construct biologically active The three-dimensional biological cell system; b. Accurately deposit different types of cell-contain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/112B33Y10/00
Inventor 龚友平何治升葛安磊王飞毕志凯刘海强陈慧鹏彭章明陈国金
Owner HANGZHOU DIANZI UNIV
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