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Chiral separation method for nicotine

A separation method and chiral separation technology, which are applied in material separation, analysis materials, measuring devices, etc., can solve the problem of inability to achieve, inability to select flow restrictors of different specifications, and inability to achieve multi-dimensional gas chromatography separation processing of nicotine extract. And other issues

Inactive Publication Date: 2019-05-21
HUBEI HENO BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a chiral separation and separation method of nicotine, which solves the problem of not being able to select different restrictor tubes and setting different constant flow modes according to the amount of nicotine extract added. Realize the grouping of nicotine extract and then multi-dimensional gas chromatography separation treatment to improve the comprehensiveness of the resolution and separation of nicotine chiral structure, and it is impossible to select different specifications of restrictor tubes according to the amount of nicotine extract , to avoid the purpose of blindness in the selection of the restrictor tube, the problem of shortening the test time and reducing the consumption of materials cannot be achieved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] S1. Material selection: first select the nicotine extract extracted from tobacco or flue gas, divide the selected nicotine extract into 4 parts, put them into reagent bottles, and then put the reagent bottle containing the nicotine extract into Put it into a constant temperature box, control the temperature at 26°C for constant temperature storage, and wait for separation treatment;

[0022] S2. Nicotine racemization treatment: take the reagent bottle containing nicotine extract in S1 out of the incubator, add 5.5mL optical reagent respectively, put the reagent bottle into the shaker, and shake at a speed of 60r / min 35min, and then stand still for 15min to complete the derivatization of nicotine to form diastereoisomers. A combination of one or more of strychnine, strychnine, ephedrine and α-phenethylamine;

[0023] S3. Selection of restrictor tube specifications in multidimensional gas chromatography: First, use the capillary column pressure flow software, according t...

Embodiment 2

[0027] S1. Material selection: first select the nicotine extract extracted from tobacco or flue gas, divide the selected nicotine extract into three parts, put them into reagent bottles, and then put the reagent bottle containing the nicotine extract into Put it into a constant temperature box, control the temperature at 25°C for constant temperature storage, and wait for separation treatment;

[0028] S2. Nicotine racemization treatment: take the reagent bottle containing the nicotine extract in S1 out of the incubator, add 5mL optical reagent respectively, put the reagent bottle into the shaker, and shake at a speed of 50r / min for 30min , and then stand for 10 minutes to complete the racemic derivatization of nicotine to generate diastereoisomers. A combination of one or more of alkaloids, strychnine, ephedrine and α-phenethylamine;

[0029] S3. Selection of restrictor tube specifications in multidimensional gas chromatography: First, use the capillary column pressure flow so...

Embodiment 3

[0033] S1. Material selection: first select the nicotine extract extracted from tobacco or flue gas, divide the selected nicotine extract into 5 parts, put them into reagent bottles, and then put the reagent bottle containing the nicotine extract into Put it into the incubator, control the temperature at 27°C for constant temperature storage, and wait for the separation process;

[0034] S2. Nicotine racemization treatment: take the reagent bottle containing the nicotine extract in S1 out of the incubator, add 6mL optical reagent respectively, put the reagent bottle into the shaker, and shake it at a speed of 70r / min for 40min , and then stand for 20 minutes to complete the racemic derivatization of nicotine to generate diastereoisomers. The optical reagents are alkaline racemic agents, tartaric acid, camphoric acid, camphor-10-sulfonic acid, glycine, and horse money A combination of one or more of alkaloids, strychnine, ephedrine and α-phenethylamine;

[0035] S3. Selection ...

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Abstract

The invention discloses a chiral separation method for nicotine. The method concretely comprises the following steps: S1, selecting a material: selecting a nicotine extract extracted from tobacco or smoke, dividing the selected nicotine extract into 3 to 5 parts, placing the divided extract parts in reagent bottles, and placing the reagent bottles filled with the nicotine extract in a thermotank.The present invention relates to the technical field of nicotine separationy. The chiral separation method for nicotine can realize the selection of different current restricting tubes and setting ofdifferent constant current modes according to the amount of the nicotine extract, and realizes grouping and multidimensional gas chromatography separation treatment of the nicotine extract to improvethe comprehensiveness of the separation of nicotine chiral structures, so the selection of the current restricting tubes with different sizes is well achieved according to the amount of nicotine extract, the blindness of the selection of the current restricting tubes is avoided, and shortening of the test time and reduction of the material consumption are achieved, thereby people can very easily perform separation of nicotine.

Description

technical field [0001] The invention relates to the technical field of nicotine separation, in particular to a chiral separation method for nicotine. Background technique [0002] The classic method for the resolution of chiral compounds is fractional crystallization, in which enantiomers are combined with an optical reagent to generate diastereoisomers, and the difference in physical properties of diastereomers is used to achieve the purpose of separation. This method The disadvantages are that the reagents are expensive, the operation is time-consuming, the post-processing is troublesome, and the limitations are large. The sample must have a reactive group. The determination of the optical purity is commonly used. The specific optical rotation method requires the content of a certain configuration in the sample It must exceed 2% of its enantiomers to be able to distinguish, and the sensitivity is low. NMR can also be used for the determination of chiral purity, but the equ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04G01N30/06G01N30/02
Inventor 方洪平杨强林文聂威贺择
Owner HUBEI HENO BIOLOGICAL ENG CO LTD
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