Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Lomatogonium carinthiacum extract, method for preparing same, pharmaceutical composition and application of pharmaceutical composition to losing weights

An extraction method and the technology of Stylodylum japonica, which are applied in the field of Mongolian medicine Stylostyle styloides extract and its preparation, can solve problems such as depression and anorexia

Pending Publication Date: 2019-05-24
INNER MONGOLIA UNIV FOR THE NATITIES
View PDF5 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, weight loss drugs commonly used in the market mainly rely on regulating food intake and satiety central nervous system to suppress appetite and achieve the effect of weight loss; however, long-term use can cause serious side effects such as anorexia, insomnia, lack of energy, depression, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lomatogonium carinthiacum extract, method for preparing same, pharmaceutical composition and application of pharmaceutical composition to losing weights
  • Lomatogonium carinthiacum extract, method for preparing same, pharmaceutical composition and application of pharmaceutical composition to losing weights
  • Lomatogonium carinthiacum extract, method for preparing same, pharmaceutical composition and application of pharmaceutical composition to losing weights

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 costal flower extract

[0025] Weigh 300g of stigmata and cut into sections and put it into a 10000mL round bottom flask, soak it in 10 times the amount of 75% ethanol overnight, put stones in the bottom of the bottle to prevent bumping, and seal it with tin foil to prevent volatilization. The next day, connect the round-bottom flask to the interface and the condenser tube, and then fill it with water. Set the temperature of the electric heating mantle to 68°C, and reflux extraction for 3 times, each time for 2 hours. After combining the extracts, use an experimental spray dryer to spray dry, spray The dryer parameters are set as follows:

[0026] Inlet air temperature setting: 180°C, actual temperature: 180°C, outlet air temperature setting: 110°C, actual temperature: 68-90°C, fan setting: 55.00, through needle setting: 5.0, peristaltic pump setting: 60.0, The drying rate is about 1500mL / h. After all the extracts enter, turn off the mac...

Embodiment 2

[0034] Example 2 The weight loss effect of the Mongolian medicine Stylostyle flower extract on high-fat and high-energy induced obese rats

[0035] 1. The purpose of the experiment To establish a high-fat and high-energy diet-induced obesity rat model, and continuously administer different concentrations of Licorice extract by intragastric administration, and observe the effect on the weight loss effect of the mice.

[0036] 2. Experimental materials

[0037] 2.1 Animals: Wistar rats, 4-5 weeks old, weighing 180g-220g, purchased from Changsheng, Liaoning, license number: SCXK (Liao) 2015-0001. They were raised in the experimental animal room of Mongolian Medicine College, Inner Mongolia University for Nationalities, with a temperature of 20±5°C, a humidity of 40%-50%, light conditions of 10h / day, and free access to food and water. The treatment of animals in the experiment complied with the relevant requirements of the "Guiding Opinions on Treating Experimental Animals" issue...

Embodiment 3

[0045] Example 3 Mongolian medicine Stylostyle flower extract to the weight loss effect of high-fat and high-energy induced obese rats

[0046] On the basis of the successful establishment of the rat obesity model, the present invention is carried out with gradient concentration weight loss efficacy experiment, divided into normal group, model group, positive group (orlistat, RocheProducts PtyLimited ABN70000132865, 0.03g / kg), low dose group (0.18g / Kg), the middle dose group (0.9g / Kg) of Stylostyle, and the high-dose group (1.8g / Kg) of Stylostyle. The feeding conditions and methods were consistent with the screening experiments. In the 6th week of administration, body weight and food intake were measured once a week, and the experimental results are shown in Table 2.

[0047] Table 2 Effect of Stylostyle flower extract on the body weight and food intake of obese rats induced by high-fat diet

[0048]

[0049] As can be seen from Table 2, the high, medium and low dose grou...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses lomatogonium carinthiacum extract, a method for preparing the same, a pharmaceutical composition and application of the pharmaceutical composition to losing weights. The lomatogonium carinthiacum extract, the method, the pharmaceutical composition and the application have the advantages that the method for extracting the lomatogonium carinthiacum extract includes simple extraction processes and is high in yield, storage can be facilitated, and reasonable utilization of wild lomatogonium carinthiacum resources further can be promoted; effects of losing the weight can berealized by the lomatogonium carinthiacum extract, the gastric emptying rates can be relieved, the passing time of food in gastrointestinal tracts can be prolonged, the satiety can be increased, accordingly, effects of reducing the food intake and the total body weights can be realized and are the effects of losing the weights without dependence on central nervous systems, and the problems of severe side effects due to effects of slimming bodies mainly by means of regulating ingestion and satiation central nerves to suppress appetite and anorexia, insomnia, dispiritedness, depression and the like in case of long-term administration can be solved by the aid of the lomatogonium carinthiacum extract.

Description

technical field [0001] The present invention relates to the field of ethnic medicines, in particular to a Mongolian medicine japonica and its pharmacological application, in particular to a Mongolian medicine japonica extract, a preparation method, a pharmaceutical composition and a weight-loss application. Background technique [0002] Lomatogonium rotatum (L.) Friesex Nym. is a Gentianaceae plant, distributed in Inner Mongolia, Heilongjiang and other places, and is an authentic medicinal material in Inner Mongolia. Bitter, cold, blunt, rough, light, and dry, it is a commonly used bitter medicinal material and specialty medicine in Mongolian medicine. The Mongolian name is transliterated as Habirigen-Digeda; It is the main traditional medicine of Mongolian medicine to treat liver and gallbladder diseases, and has remarkable clinical curative effect. However, currently 100% of wild resources of Stylophyllum medicinal materials, coupled with human interference and blind mini...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/51A61K36/708A61P3/04A23L33/105
Inventor 付明海阿丽沙巴根那包特日格乐包明兰王欢白梅荣拉喜那木
Owner INNER MONGOLIA UNIV FOR THE NATITIES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com