Application of linarin to preparing kidney tubular epithedial cell ischemia reperfusion injury protecting drugs/drug combinations

An ischemia-reperfusion and epithelial cell technology, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve the problem of unclear role of ETS2 protein, and achieve the effect of broadening the scope of application.
CN109908167AActive Publication Date: 2019-06-21THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
Publication Date
2019-06-21

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Abstract

The invention discloses application of linarin to preparing kidney tubular epithedial cell ischemia reperfusion injury protecting drugs / drug combinations and belongs to the field of biological medicines. The application proves the possibility of protecting effects of the linarin on kidney ischemia reperfusion, and through data, discovers that reducing expression of ETS2 proteins can inhibit proinflammatory factors IL-12 and accordingly inhibit inflammation to achieve the protecting effects on kidney tubular epithedial cell ischemia reperfusion injury; further only through the molecule dockingtechnology, possibility of interaction between the linarin and the ETS2 proteins is analyzed, and a theoretical foundation for enlarging the possible application range of the linarin is provided. Theapplication of the linarin to preparing the kidney tubular epithedial cell ischemia reperfusion injury protecting drugs / drug combinations can be applied to theoretical research and clinical treatmentof kidney ischemia reperfusion injury and provide the theoretical foundation for enlarging the possible application range of the linarin.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to the application of fenugreek in the preparation of a drug / medicine composition for protecting renal tubular epithelial cells from ischemia-reperfusion injury. Background technique

[0002] Acute kidney injury (Acute Kidney Injury, AKI) is a common clinical critical disease. Studies have shown that the mortality rate of AKI is as high as 50% to 79%, and the proportion of survivors who develop into chronic renal failure is as high as 35% to 71%. Injury is one of the most common causes of AKI. A large number of animal model experiments and human histopathological studies of renal ischemia-reperfusion injury have shown that inflammation is the most important pathophysiological change of ischemia-reperfusion acute kidney injury.

[0003] Menghuaside (CAS: 480-36-4) is the extract of wild chrysanthemum flower, its chemical formula is C 28 h 32 o 14 , with a molecular weight o...

Claims

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