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Cough-relieving loquat aerosol-inhalation solution preparation and preparing method thereof

An aerosol inhalation and preparation technology, which is applied in the field of preparation, can solve the problems of hidden dangers of use and the lack of standardized use methods in the instructions, and achieves the effects of less dosage, fast onset and high bioavailability.

Inactive Publication Date: 2019-06-28
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical practice, nebulized inhalation with injection is often used, but there is no standardized method of use in the instructions, and there are potential safety hazards in use
There is also no special preparation for cough loquat prescription aerosol inhalation in the prior art

Method used

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  • Cough-relieving loquat aerosol-inhalation solution preparation and preparing method thereof
  • Cough-relieving loquat aerosol-inhalation solution preparation and preparing method thereof
  • Cough-relieving loquat aerosol-inhalation solution preparation and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Cough loquat aerosol inhalation solution 200 sticks:

[0034]

[0035] Weigh loquat leaves, Morus alba, Baiqian, Baibu, Platycodon grandiflora, add ten times the water and decoct twice, filter, combine the filtrate, concentrate to relative density (1.10~1.20), let cool, add ethanol, until ethanol content of 70%, stir well, refrigerate overnight, take the supernatant, filter, recover ethanol until it has no alcohol smell, add ethanol until the alcohol content is 85%, stir well, refrigerate overnight, take the supernatant, Filter, add 10% NaOH to adjust the pH value to 9-10, stir well, let it stand for 1 hour, take the supernatant, filter, recover ethanol until it has no alcohol smell, add half the amount of water, stir well, let stand for 24 hours, take the upper Filter the clear liquid, add 0.5% activated carbon and boil for 30 minutes, let cool, filter, add menthol, add water to make up the volume, adjust the pH value to 6.8, potting, and sterilizing to obtain the p...

Embodiment 2

[0037] Cough loquat aerosol inhalation solution 200 sticks:

[0038]

[0039] Weigh loquat leaves, Morus alba, Baiqian, Baibu, and Platycodon grandiflora, add eight times the water and decoct three times, filter, combine the filtrate, concentrate to relative density (1.10-1.20), let cool, add ethanol, to the ethanol content 75%, stir well, refrigerate overnight, take the supernatant, filter, recover ethanol until there is no alcohol smell, add ethanol until the alcohol content is 90%, stir well, refrigerate overnight, take the supernatant, filter After that, add 10% NaOH to adjust the pH value to 9-10, stir well, let stand for 1 hour, take the supernatant, filter, recover ethanol until there is no alcohol smell, add half the amount of water, stir well, let stand for 24h, take the supernatant Liquid filtration, add 0.5% activated carbon, boil for 30 minutes, let cool, filter, add menthol, add water to make up the volume, adjust the pH value to 6.8, potting, and sterilizing t...

Embodiment 3

[0041] Cough loquat aerosol inhalation solution 200 sticks:

[0042]

[0043] Weigh the five flavors of loquat leaves, Morus alba, Baiqian, Baibu, and Platycodon grandiflorum according to the prescription, add ten times the amount of water to decoct twice, filter, combine the filtrate, concentrate to relative density (1.10-1.20), let cool, Add ethanol until the ethanol content is 80%, stir well, let stand and refrigerate overnight, take the supernatant, filter, recover the ethanol until it has no alcohol smell, add ethanol until the alcohol content is 90%, stir well, let stand and refrigerate overnight, Take the supernatant, filter, add 10% NaOH to adjust the pH value to 9-10, stir well, let it stand for 1 hour, take the supernatant, filter, recover the ethanol until it has no alcohol smell, add half the amount of water, stir well, let stand Set aside for 24 hours, take the supernatant and filter, add 0.5% activated carbon and boil for 30 minutes, let cool, filter, add mentho...

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Abstract

The invention relates to a cough-relieving loquat aerosol-inhalation solution preparation and a preparing method thereof, and belongs to the field of pharmaceutics. The cough-relieving loquat aerosol-inhalation solution preparation is prepared from raw Chinese medicine materials and Chinese medicine ingredients including folium eriobotryae, cortex mori radicis, willowleaf swallowwort rhizome, radix stemonae, radix platycodonis, menthol, an isotonic agent and a solvent, wherein the use amount ratio of the folium eriobotryae to the cortex mori radicis to the willowleaf swallowwort rhizome to theradix stemonae to the radix platycodonis to the menthol is (200-500):(100-400):(50-300):(40-200):(30-180):(1-10). According to the cough-relieving loquat aerosol-inhalation solution preparation, through an atomizer, aerosol can be quickly formed and directly and quickly acts on a diseased part, and is quickly absorbed to take effect; the dosage is small, the preparation takes effect quickly, hasa good curative effect, and is free of other toxic or side effects.

Description

technical field [0001] The invention relates to a solution preparation for antitussive loquat atomized inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Cough-relieving loquat is composed of loquat leaves, mulberry bark, white front, hundred buds, platycodon grandiflora, menthol and other ingredients. Loquat leaves: clearing lung and relieving cough, lowering adverse flow and relieving vomiting; Morus alba: purging lung and relieving asthma, diuresis and reducing swelling; Baiqian: lowering qi and reducing phlegm, relieving cough. Baibu: Moisturizing the lungs, lowering qi, relieving cough, and killing insects; Campanulaceae: dispersing the lungs, eliminating phlegm, relieving throat, and draining pus; Menthol: aromatic medicine, flavoring medicine and carminative. Cough-relieving loquat has the effects of clearing the lungs, relieving cough, and reducing phlegm. It is used for cough, phlegm, bronchitis and other ...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K9/08A61K47/02A61K47/26A61K36/904A61P11/00A61P11/14A61P11/10
Inventor 张保献胡杰
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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