Preparation method of compound honeysuckle particles

Abstract

The invention discloses a preparation method of compound honeysuckle particles. The defects in the prior preparation art are overcome, honeysuckle flowers are warmly soaked by water, a warm soaking extracting solution is combined with a fructus forsythiae and scutellaria baicalensis water decoction filtering medium, and the compound honeysuckle particles are prepared through the steps of alcohol precipitation, concentration, drying, ultra fine smashing, granulation and the like, the prepared compound honeysuckle particles have the advantages of being simple in technology, high in work efficiency and low in energy dissipation, by adopting the ultra fine smashing technology, medicine absorption is rapid, and the effect is achieved rapidly.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a preparation method of compound honeysuckle granules. Background technique [0002] Compound Honeysuckle Granules is recorded in the National Drug Standard (2014) No. Z-0862. The product is composed of three traditional Chinese medicines: honeysuckle, forsythia, and scutellaria baicalensis. Heat and cold, pharyngitis, tonsillitis, eye pain, toothache, carbuncle, sore and furuncle and other diseases. Its preparation method is as follows: the above three flavors, honeysuckle are distilled with water for 7 hours, the distillate is collected, stored in another container, the distilled aqueous solution is filtered, the dregs of the medicine are added with an appropriate amount of water, decocted for 30 minutes, filtered, and the filtrates are combined twice. The density is about 1.25 (60°C), add 3 times the amount of ethanol, stir, refrigerate and stand for 24 hours, fi...

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Problems solved by technology

[0005] The compound honeysuckle granule prepared by the above preparation method is basically the same as the process prepared in the National Drug Standard (2014) Guoyao Zhunzi No. Z-0862, and some procedures are more complicated. The applicant believes that there are still the following defects: (1) adding water to the honeysuckle When distilling, whether it is directly distilled by passing water vapor, or adding a certain amount of water to honeysuckle and then heating and distilling, there is no specific determination. In addition, there is no water addition and specific distillation time. If less water is added and the distillation time is shorter, the transfer rate of its active ingredients Low, if more water is added, the distillation time will be long, which will cause waste of energy and reduce work efficiency; (2) the medicinal residues after the distillation of honeysuckle are decocted with water, and there is also no definite amount of water added and decoction time, the amount of water added and the decoction time The length and effect of the above-mentioned honeysuckle distillation are the same; (3) have the same defect as the national standard, the technological process is too complicated, which increases production costs, increases energy consumption, and increases the cost per unit product; (4) When the first honeysuckle thick paste and the first forsythia scutellaria baicalensis mixed thick paste become the second honeysuckle thick paste and the second forsythia scutellaria baicalensis mixed thick paste through alcohol precipitation, the amount of ethanol is added according to the ratio of 1:3, Carry out alcohol precipitation according to this method, the process is difficult to control, because if the density of the first honeysuckle thick paste and the first forsythia scutellaria baicaleni mixed thick paste have deviations, the ethanol concentration of the medicinal solution after alcohol precipitation will be different, and its composition will be different. will vary, and the pharmacological effects will be different

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