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A kind of high refractive index hydrophobic foldable intraocular lens material and its preparation method

A technology of intraocular lens and high refractive index, which is applied in the fields of prosthesis, tissue regeneration, medical science, etc., can solve the problems of unstable homogeneity of polymer materials, the optical performance needs to be improved, and it is difficult to recover completely, so as to reduce the cost of implant surgery. Risk and cost, ease of industrial production, and the effect of simple preparation

Active Publication Date: 2021-03-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Specifically aiming at solving the key problems such as poor flexibility of most materials in the existing intraocular lens, difficulty in recovering completely after folding or non-folding, optical performance to be improved, and unstable polymer material uniformity, a stable foldable intraocular lens unit has been prepared. Bulk polymer, the resulting material has better mechanical and optical properties so that it has a high level of folding performance and refractive index, thereby meeting the performance requirements of a higher degree of freedom in material processing control thickness

Method used

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  • A kind of high refractive index hydrophobic foldable intraocular lens material and its preparation method
  • A kind of high refractive index hydrophobic foldable intraocular lens material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Select and weigh monomers: in the first part B monomers, B1 is 2-phenoxyethyl methacrylate, accounting for 55% of the total monomer mass, and B2 is 2-phenoxyethyl acrylate, accounting for 35% of the total monomer mass; the second part C monomer is 2-ethylhexyl methacrylate, accounting for 8% of the total monomer mass; the third part crosslinking agent D is ethylene glycol dimethacrylate Esters account for 2% of the total monomer mass (B+C+D=100%); the initiator is (2-ethylhexyl) tert-butyl peroxide, and the initiator accounts for 2% of the total reactant mass.

[0031] Add each part of the monomer and initiator that has been weighed into a polytetrafluoroethylene beaker and mix thoroughly, then quantitatively move into a specific polytetrafluoroethylene mold (the aspect ratio is 10:4:1), and add to the mixed solution Nitrogen was introduced into the mold for 20 minutes, the mold was placed in a vacuum oven and then heated to 80°C, and the temperature was kept constant f...

Embodiment 2

[0034] Select and weigh the monomers: in the first part B monomers, B1 is 2-phenoxyethyl methacrylate, accounting for 60% of the total monomer mass, and B2 is 2-phenoxyethyl acrylate, accounting for 36% of the total monomer mass; the second part C monomer is 2-ethylhexyl methacrylate, accounting for 2% of the total monomer mass; the third part crosslinking agent D is ethylene glycol dimethacrylate The ester accounts for 2% of the total monomer mass (B+C+D=100%); the initiator is (2-ethylhexyl) tert-butyl peroxide, which accounts for 2% of the total reactant mass.

[0035] Add each part of the monomer and initiator that has been weighed into the polytetrafluoroethylene beaker in turn and mix thoroughly, then quantitatively transfer it into a specific polytetrafluoroethylene mold, pass nitrogen into the mixed solution for 20 minutes, and place the mold in a vacuum After filling the oven with vacuum, heat it to 80°C, keep the temperature constant for a pre-reaction for 2 hours, t...

Embodiment 3

[0038] Select and weigh the monomers: in the first part B monomers, B1 is 2-phenoxyethyl acrylate, accounting for 60% of the total monomer mass, and B2 is 2-ethylhexyl methacrylate, accounting for the total 36% of the monomer mass; the second part C monomer is methacrylate-3,5,5-trimethylhexyl ester, accounting for 2% of the total monomer mass; the third part crosslinking agent D is the molecular weight of 1000 Polyethylene glycol dimethacrylate accounts for 2% of the total monomer mass; the initiator is (2-ethylhexyl) tert-butyl peroxide, which accounts for 2% of the total reactant mass.

[0039] Add each part of the monomer and initiator that has been weighed into the polytetrafluoroethylene beaker in turn and mix thoroughly, then quantitatively transfer it into a specific polytetrafluoroethylene mold, pass nitrogen into the mixed solution for 20 minutes, and place the mold in a vacuum After filling the oven with vacuum, heat it to 90°C, keep the temperature constant for a p...

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Abstract

The invention provides a high-refractive-index hydrophobic foldable intraocular lens material, which consists of three parts of monomers formed by free radical polymerization. The first part of monomer B is a polymerizable monomer containing phenyl, specifically including B1 and B2 Two parts, wherein B1 accounts for 50%-60% of the total monomer content, B2 accounts for 30-40% of the total monomer content, and the B1 and B2 are different; the second part of the monomer C is a branched alkyl chain acrylic acid or methacrylate, accounting for 1-10% of the total monomer content; the third part monomer D is a crosslinking agent, accounting for 1.5-2.5% of the total monomer content; the total monomer content is three parts The sum of monomers B+C+D. Compared with common intraocular lens materials, the intraocular lens material provided by the present invention has higher key optical performance parameters such as transmittance and refractive index. required material properties.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a high-refractive-index hydrophobic foldable intraocular lens material and a preparation method thereof. Background technique [0002] The natural lens of the normal human eye is clear and transparent, but with the increase of age, abnormalities and lesions in the body's own immune and metabolic systems, trauma caused by objective accidents, etc., the natural lens is damaged and cannot be maintained normally. A condition in which the natural lens changes from clear to cloudy is called a cataract. Because the natural lens changes from transparent to cloudy, visible light cannot pass through the natural lens and focus on the retina, which causes cataract patients to have varying degrees of visual impairment or even complete blindness. In this case, cataract patients need to be replaced with new lenses with normal performance, and intraocular lenses (Intraocular Lens...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/30C08F220/18C08F222/14C08F290/06A61L27/16A61L27/50
CPCA61L27/16A61L27/50A61L2430/16C08F220/30C08F290/062C08F220/301C08L33/14C08L51/08C08F220/1806C08F222/102
Inventor 刘公岩兰天翔王海波朱瑞鑫聂宇
Owner SICHUAN UNIV
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