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Eye drop containing olopatadine hydrochloride and preparation method thereof

A technology of olopatadine hydrochloride and eye drops, which is applied in the field of medicine, can solve the problems of unsatisfactory requirements and poor effect of allergic conjunctivitis, and achieve the effect of less medication times, significant therapeutic effect and high stability

Inactive Publication Date: 2019-07-16
合肥华威药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, olopatadine hydrochloride can only stop the release of a large amount of histamine that causes allergic reactions in the earliest stage, that is, the effect on early allergic reactions is more significant, and the effect on late allergic conjunctivitis is relatively poor, and the olopatadine hydrochloride There will be side effects such as headache after regular use, and the requirements of the people for allergic conjunctivitis eye drops cannot be satisfied.

Method used

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  • Eye drop containing olopatadine hydrochloride and preparation method thereof
  • Eye drop containing olopatadine hydrochloride and preparation method thereof
  • Eye drop containing olopatadine hydrochloride and preparation method thereof

Examples

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Embodiment 1-3

[0037]Table 1: Formula table of the eye drops containing olopatadine hydrochloride in Example 1-3

[0038]

[0039]

[0040] Among the eye drops containing olopatadine hydrochloride prepared in Table 1, Example 2 is the best example. According to the technical scheme of the present invention, the optional adjuvant varieties for preparing the eye drops containing olopatadine hydrochloride are not limited to the varieties listed in the above table, and can also have the following multiple options:

[0041] As bacteriostatic agent, any bacteriostatic agent called in pharmacy can be used, and its consumption is according to the conventional dosage in pharmacy. For example, ①0.002%-0.005% thimerosal; ②quaternary ammonium salts (including benzalkonium chloride, benzalkonium bromide), dumiphene, chlorhexidine, etc., the effective concentration is 0.002%-0.01%; ③alcohols, commonly used 0.3-0.6% chlorobutanol; ④ Parabens, commonly used 0.03-0.06% ethylparaben; ⑤ Acids, such as 0...

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Abstract

The present invention belongs to the technical field of medicines and particularly relates to an eye drop containing olopatadine hydrochloride and a preparation method thereof. The provided eye drop containing the olopatadine hydrochloride mainly consists of the olopatadine hydrochloride, a cassia seed extract, pharmaceutically acceptable eye drop accessory materials and water for injection. Every100 mL of the eye drop contains 0.095-0.110 g of the olopatadine hydrochloride, and a weight ratio of the olopatadine hydrochloride to the cassia seed extract is 1:(1-3). The provided eye drop containing the olopatadine hydrochloride has advantages of remarkable therapeutic effects, high in stability, small toxic and side effects, etc., and is a relatively ideal eye drop for treating allergic conjunctivitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to an eye drop containing olopatadine hydrochloride and a preparation method thereof. Background technique [0002] Allergic conjunctivitis, also known as allergic conjunctivitis, is a hypersensitivity reaction of the conjunctiva to external allergens, and is a relatively common ocular surface disease in clinical practice. The clinical manifestations of allergic conjunctivitis mainly include eye itching, tearing, eye redness, burning sensation, photophobia, increased secretions, etc., which seriously affect the daily life of patients. [0003] Histamine is the most inflammatory mediator contained in the early stage of allergic reaction and when symptoms appear, and inhibiting the activity of inflammatory mediators such as histamine is the focus of treating inflammation. Since the discovery of histamine in 1910 and the development of the first antihistamine compound...

Claims

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Application Information

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IPC IPC(8): A61K36/482A61K9/08A61K47/38A61K47/36A61K47/32A61P27/02A61P37/08A61K31/335
CPCA61K9/0048A61K9/08A61K31/335A61K36/482A61K47/32A61K47/36A61K47/38A61P27/02A61P37/08A61K2300/00
Inventor 黄凌云王延东
Owner 合肥华威药业有限公司
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