Flexible surface enhanced Raman detection substrate and preparation method and preparation system thereof

Abstract

The invention discloses a flexible surface enhanced Raman detection substrate, a preparation method and a preparation system thereof, which comprises a film substrate layer, a cured resin layer, a plurality of convex structures and a gold thin film layer, wherein the cured resin layer is attached to the surface of the film substrate layer and is doped with nano silver particles; the nano convex structures are distributed on the surface of the cured resin layer and made of resin doped with nano silver particles, and the nano silver particles are distributed on the surfaces of the convex structures; and the gold thin film layer is attached to the surfaces of the cured resin layer and the convex structure. The substrate has better enhancement effect of Raman scattering signals and higher detection precision and accuracy.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a flexible surface-enhanced Raman detection substrate based on a multi-level nanostructure, a preparation method and a preparation system thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] With the development of agricultural industrialization, the production of agricultural products is increasingly dependent on exogenous substances such as pesticides, antibiotics and hormones. The unreasonable use of these substances will inevitably lead to excessive pesticide residues in agricultural products, affecting the food safety of consumers. It will cau...

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Problems solved by technology

[0004] The inventors of the present application have found through research that the reported surface-enhanced Raman detection substrates have problems such as high cost, poor repeatability, and cumbersome manufacturing processes.

For example, Chinese patent CN 109187487 A discloses a surface-enhanced Raman scattering substrate of silver nanoclusters. This patent realizes Raman signal enhancement based on single-scale silver nanoparticles. Due to the random distribution of silver nanoparticles, it cannot guarantee the accuracy of multiple detections. repeatability

Chinese patent CN 108956579 A discloses a surface-enhanced Raman scattering substrate based on metal magnetic beads. Through the repeated vibration of an external magnetic field, the metal magnetic beads are distributed on the surface of the substrate body, which has low preparation efficiency and difficulty in controlling the consistency of the metal magnetic beads. Not enough

Chinese patent CN 109239051 A discloses a flexible transferable surface-enhanced Raman detection substrate, in which thiolated polystyrene is modified onto noble metal nanoparticles through ligand exchange, and then self-assembled through the gas-liquid interface in the An ordered substrate-free self-supporting two-dimensional noble metal nano-superlattice film is assembled on a porous substrate to obtain a flexible and transferable SERS substrate. This patent has the disadvantages of complex manufacturing process and low efficiency.

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