Qinlan solution preparation used for inhalation and preparation method thereof
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A solution and preparation technology, applied in the field of pharmacy, can solve the problems of few products, no use of atomized inhalation preparations, and no suitable dosage form, etc., and achieve the effects of quick onset, easy industrial production, and low dosage
Inactive Publication Date: 2019-08-06
INCREASEPHARM HENGQIN INST CO LTD
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Problems solved by technology
At present, there are relatively few products on the market for nebulized inhalation solution preparations, mainly imported products
However, Qinlan Oral Liquid is an oral dosage form, and there is no clinical application of nebulized inhalation preparations.
At the same time, traditional Chinese medicine has a good effect on cough, phlegm, dyspnea, dry mouth, hoarseness, sore throat, etc., but because there is no suitable dosage form, it can better exert its effect
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Embodiment 1
[0039] The dosage of raw materials in this example: 50g of honeysuckle, 100g of forsythia, 50g of Radix isatidis, 20g of Scutellaria baicalensis.
[0040] (1) Preparation of Radix isatidis extract: take 50g of Radix Radix, add 10 times of water for the first time, decoct for 2 hours, add 8 times of water for the second time, decoct for 1 hour, filter, combine the filtrates, concentrate to 1ml containing 2g of crude drug, Add ethanol until the alcohol content is 80%, stir well, let stand for more than 12 hours, filter, recover ethanol until 1ml contains 4g of crude drug, add water until 1ml contains 0.5g of crude drug, let stand for more than 24 hours, filter, concentrate until 1ml contains 5g of crude drug , add ethanol until the alcohol content is 85%, stir well, let stand for more than 12 hours, filter, recover ethanol until 1ml contains 10g crude drug, add water until 1ml contains 1g crude drug, pass through the treated macroporous resin column, wash with water, Elute with 40...
Embodiment 2～5
[0045] Embodiments 2 to 5 are different from Example 1 except that the dosage relationship and some parameters of Radix Radix Radix, Scutellaria, Honeysuckle, and Forsythia are different from Example 1, and other parameters and operations are the same as Example 1; the specific dosage relationship and parameters of Examples 2 to 5 are shown in the table 1 shows:
[0046] The dosage relation of table 1 embodiment 2~5 honeysuckle, forsythia, Radix Radix, Radix Scutellariae
[0047]
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Abstract
The invention belongs to the field of a preparation, and particularly relates to a Qinlan solution preparation used for inhalation and a preparation method thereof. The Qinlan solution preparation comprises a honeysuckle flower and Fructus Forsythiae extract, an isatis root extract, a radix scutellariae extract, an auxiliary agent and a solvent; the honeysuckle flower and Fructus Forsythiae extract is prepared by honeysuckle flower and Fructus Forsythiae, the isatis root extract is prepared by isatis root, and the radix scutellariae extract is prepared by the radix scutellariae. The Qinlan solution preparation is safe, effective and high in bioavailability, and has the advantages of low usage dosage, quick onset, good curative effect and no other side effects.
Description
technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation of Qinlan solution for inhalation and a preparation method thereof. Background technique [0002] Honeysuckle is the dry flower bud or the first bloomed flower of Lonicera japonica Thunb., Lonicera japonica Thunb. Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi, a plant of the Labiatae family. It is bitter in taste and cold in nature. It returns to the lung, gallbladder, spleen, large intestine, and small intestine meridians. It has the effects of clearing away heat and dampness, purging fire and detoxifying. Forsythia suspense (Thunb.) Vahl is the dried fruit of Forsythia suspense (Thunb.) Vahl. It tastes bitter and slightly cold. Banlangen is the dried root of Isatis indigotica Fort., a cruciferous plant. It tastes bitter and cold in nature. [0003] Honeysuckle, scutellaria, forsythia and isatis root are traditional Chinese medici...
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