Clathrate containing non-psychoactive cannabinoid and preparation method of clathrate

A technology of clathrates and cannabinoids, applied in the field of clathrates containing non-psychoactive cannabinoids and its preparation, can solve the problem of inability to remove non-psychoactive cannabinoids at the same time, limit the development and application of cannabinoid drugs, and cannot simultaneously Removal and other issues

Inactive Publication Date: 2019-08-16
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing technology is currently unable to simultaneously remove non-psychoactive cannabinoids such as CBN, THC, THCV
And only remove THC, can not remove THCV, CBN at the same time, which limits the development and application of cannabinoids to a certain extent

Method used

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  • Clathrate containing non-psychoactive cannabinoid and preparation method of clathrate
  • Clathrate containing non-psychoactive cannabinoid and preparation method of clathrate
  • Clathrate containing non-psychoactive cannabinoid and preparation method of clathrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] The steps for the preparation of clathrates containing non-psychoactive cannabinoids are as follows:

[0084] (1) Take 10kg of marijuana flowers and leaves, add 100kg of 75% ethanol, stir and extract at room temperature for 1 hour, extract twice, combine the extracts, concentrate under reduced pressure to a density of 1.014 (50°C), and purify through a styrene-type macroporous resin column , after loading the sample, let stand for adsorption for 30 minutes, then use 5 times the column volume of purified water, 3 times the column volume of 55% ethanol, and 6 times the volume of 85% ethanol to elute, collect the 85% ethanol eluate, Concentrate under reduced pressure to a thick paste;

[0085] (2) Add an appropriate amount of 95% (v / v, the same below) ethanol to the thick paste obtained in step (1), stir and dissolve to obtain an ethanol solution;

[0086] (3) Weigh 50kg of β-cyclodextrin, add 300kg of purified water, heat and stir at 60°C to dissolve, and obtain an inclu...

Embodiment 2

[0102] The steps for the preparation of clathrates containing non-psychoactive cannabinoids are as follows:

[0103] (1) Take 10kg of marijuana flowers and leaves, add 100kg of 95% ethanol, stir and extract at room temperature for 0.5 hours, extract 4 times, combine the extracts, concentrate under reduced pressure to a density of 1.014 (50°C), and purify through a styrene-type macroporous resin column , after loading the sample, let stand for adsorption for 30 minutes, then use 5 times the column volume of purified water, 3 times the column volume of 55% ethanol, and 6 times the volume of 85% ethanol to elute, collect the 85% ethanol eluate, Concentrate under reduced pressure to a thick paste;

[0104] (2) adding an appropriate amount of 95% isopropanol to the thick paste obtained in step (1), stirring and dissolving to obtain an isopropanol solution;

[0105] (3) Weigh 10 kg of 2-hydroxypropyl-β-cyclodextrin, add 100 kg of purified water, heat and stir at 70°C to dissolve, a...

Embodiment 3

[0111] The steps for the preparation of clathrates containing non-psychoactive cannabinoids are as follows:

[0112] (1) Take 10kg of marijuana flowers and leaves, add 150kg of 75% ethanol, stir and extract at room temperature for 1 hour, extract 3 times, combine the extracts, concentrate under reduced pressure and the density is 1.014 (50°C), and purify through a styrene-type macroporous resin column , after loading the sample, let stand for adsorption for 30 minutes, then use 5 times the column volume of purified water, 3 times the column volume of 55% ethanol, and 6 times the volume of 85% ethanol to elute, collect the 85% ethanol eluate, Concentrate under reduced pressure to a thick paste;

[0113] (2) adding an appropriate amount of acetone to the thick paste obtained in step (1), stirring and dissolving to obtain an acetone solution;

[0114] (3) Weigh 100kg of 3-hydroxypropyl-β-cyclodextrin, add 400kg of purified water, heat and stir at 50°C to dissolve, and obtain an ...

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Abstract

The invention discloses a clathrate containing non-psychoactive cannabinoid and a preparation method of the clathrate. The preparation method includes sequentially subjecting hemp extract to dissolution by organic solvents, clathration by clathration agents, decomposition and impurity removal by water-organic solvents, and vacuum drying and precipitation. The clathrate can completely remove psychoactive components such as tetrahydrocannabinol (THC) and delta 9-tetrahydrocannabivarin (THCV), and effectively enrich non-psychoactive components with the total content of more than 50%, such as cannabidiol (CBD), cannabigerol (CBG) and cannabichromene (CBC). The preparation method has the advantages of simple process and easiness in industrialization.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine chemistry and preparation, in particular to an inclusion compound containing non-psychoactive cannabinoids and a preparation method thereof. Background technique [0002] Inclusion compound refers to a special compound formed by one molecule being fully or partially included in the hole structure of another molecule. The compound is formed by the combination of drug molecules and inclusion material molecules through van der Waals force. , the molecules that are included are called inclusion agents or guest molecules, and the molecules with a hole structure are called inclusion agents or host molecules. As a pharmaceutical preparation technology, the preparation technology of clathrates has developed rapidly. It can improve the bioavailability of insoluble drugs, improve the stability of drugs, taste masking, solidification of oily drugs, mask bad smell or taste of drugs, regul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K8/34A61K8/49A61K8/73A61K8/9789A61K31/05A61K31/352A61K47/69A61Q19/00A61K127/00A61K125/00A61K131/00A61K133/00A61K135/00
CPCA61K36/60A61K31/05A61K31/352A61K47/6951A61K8/9789A61K8/347A61K8/498A61K8/738A61Q19/00A61K2800/10A61K2800/56A61K36/185A61Q13/00A61Q11/00
Inventor 孙武兴谭昕张景金倩王曙宾邢俊波
Owner HANYI BIO TECH CO LTD
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