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Application of pyrroloquinoline quinine in relieving animal cell and intestinal inflammation induced by lipopolysaccharide

A technology of pyrroloquinoline quinone and inflammatory response, which is applied in the fields of application, animal feed, animal feed, etc., to achieve the effects of alleviating structural damage, improving breeding efficiency, and alleviating growth inhibition

Pending Publication Date: 2019-08-23
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no research report on whether PQQ has an anti-inflammatory effect on animals under the state of animal immune stress induced by exogenous stressors

Method used

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  • Application of pyrroloquinoline quinine in relieving animal cell and intestinal inflammation induced by lipopolysaccharide
  • Application of pyrroloquinoline quinine in relieving animal cell and intestinal inflammation induced by lipopolysaccharide
  • Application of pyrroloquinoline quinine in relieving animal cell and intestinal inflammation induced by lipopolysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Application of PQQ in alleviating LPS-induced macrophage inflammation

[0023] Poultry macrophages (HD11) were pretreated with 5 μM PQQ for 12 hours, and then 100 ng / mL LPS cells were used for 12 hours to detect the production of NO and the expression level of iNOS, as well as the inflammatory factors (IL-1B, IL-6, Expression levels of IL-10 and TNF-α). The results showed that: PQQ can significantly reduce the production of macrophage NO and the expression level of iNOS, and significantly reduce the expression level of inflammatory factors (IL-1B, IL-6, IL-10 and TNF-α), such as Figure 1-6 .

Embodiment 2

[0024] Example 2 An immunoregulatory feed additive for alleviating intestinal inflammatory damage in animals, its components and mass percentages are: PQQ: 1%, vitamin E: 0.5%, BHT: 0.6%, silymarin: 0.4%, rice bran: 97.5%.

Embodiment 3

[0025] Example 3 An immunoregulatory feed additive for alleviating intestinal inflammatory damage in animals, its components and mass percentages are: PQQ: 0.8%, vitamin E: 0.7%, BHT: 0.8%, silymarin: 0.2%, rice bran: 97.5%.

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Abstract

The invention provides an immunomodulator for relieving animal cell and intestinal inflammatory responses induced by lipopolysaccharide (LPS) and application of the immunomodulator. The immunomodulator is pyrroloquinoline quinone (PQQ). PQQ is applied to relieving inflammatory injury of LPS-induced macrophages and animal bodies for the first time. The invention also provides a preparation method of a feed additive for relieving animal cell and intestinal inflammatory injury and application of the feed additive in animal production. PQQ serves as the immunomodulatory type feed additive, and caneffectively relieve the animal cell and intestinal inflammatory injury induced by harmful microorganisms and improve the antioxidant function of organisms. By propelling the application of the immunomodulatory type feed additive in livestock production is beneficial to improving the immune function and antioxidant function of the animal bodies, reducing the occurrence of epidemic diseases and improving economic benefits of livestock and poultry farmers.

Description

technical field [0001] The invention belongs to the technical field of animal husbandry, and mainly relates to an immunomodulator for alleviating animal cell and intestinal inflammation induced by lipopolysaccharide (LPS) and application thereof. Background technique [0002] Pyrroloquinoline quinone (PQQ) is the coenzyme of methanol dehydrogenase, and is the third prosthetic group found in membrane-bound bacterial dehydrogenase after flavin nucleotide and nicotinamide nucleotide. If recognized by the World Health Organization, this would become the 14th vitamin. PQQ is similar to water-soluble B vitamins, and it exists in almost all foods, with a content of about 3.65-61.0 ng / g. Experimental mice deficient in this substance exhibit such phenomena as reduced reproductive capacity, and it is presumed that it has the same effect on humans. PQQ exists in human viscera, testes and body fluids, and the spleen has the highest content, reaching 5.9ng / g. The total content of PQQ ...

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61K31/355A61K31/357A61K31/05A61P29/00A61P37/02A61P39/06A61P1/16A23K20/137A23K20/174A23K20/111A23K20/10A23K10/37A23K50/75
CPCA61K31/05A61K31/355A61K31/357A61K31/4745A23K10/37A23K20/10A23K20/111A23K20/137A23K20/174A23K50/75A61P1/16A61P29/00A61P37/02A61P39/06A61K2300/00Y02P60/87
Inventor 赵丽红张建云马秋刚郑雅文郭永鹏
Owner CHINA AGRI UNIV
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