Ionic liquid-promoted one-pot method for synthesizing 4H-pyranocoumarin derivatives
A technology of coumarin derivatives and ionic liquids, applied in chemical instruments and methods, organic compound/hydride/coordination complex catalysts, chemical/physical processes, etc., to achieve convenient recycling, high atom economy, and easy operation and the effect of simple post-processing
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Embodiment 1
[0022] Add 0.5mmol functionalized ionic liquid [TEOA][Ac], 0.5mmol 4-hydroxycoumarin, 0.5mmol benzaldehyde and 0.5mmol malononitrile in a round bottom flask, stir and mix with magnetic force, and stir at room temperature Reaction for 1.5h. TLC is used to track and monitor the whole process. After the reaction is over, add water twice for washing and centrifugation. After several times, wash with n-hexane to obtain pure product. Then it was placed in an oven and dried at 50°C, and the yield was 71%.
Embodiment 2
[0024] Add 0.5mmol functionalized ionic liquid [TEOA][Ac], 0.5mmol 4-hydroxycoumarin, 0.5mmol 4-nitrobenzaldehyde and 0.5mmol malononitrile into the round-bottom flask. The reaction was stirred at room temperature for 0.5h, and the whole process was monitored by TLC. After the reaction is over, add water twice for washing and centrifugation. After several times, wash with n-hexane to obtain pure product. Then it was placed in an oven and dried at 50°C, and the yield was 95%.
Embodiment 3
[0026] Add 0.5mmol functionalized ionic liquid [TEOA][Ac], 0.5mmol 4-hydroxycoumarin, 0.5mmol 3-nitrobenzaldehyde and 0.5mmol malononitrile into the round-bottom flask successively. The reaction was stirred at room temperature for 50 min. TLC is used to track and monitor the whole process. After the reaction is over, add water twice for washing and centrifugation. After several times, wash with n-hexane to obtain pure product. Then it was placed in an oven and dried at 50°C. The yield was 91%.
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