Preparation method of in vivo targeted ovarian cancer cell imaging nano material composed of multifunctional macromolecule and metal-organic frames (MOFs)

A technology of metal-organic framework and ovarian cancer cells, which is applied in the field of nano-biomedical materials, can solve the problems of poor targeting, and achieve the effect of satisfying production and application, good physical and chemical stability, and simple process
CN110170059AInactive Publication Date: 2019-08-27SHANGHAI NAT ENG RES CENT FORNANOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI NAT ENG RES CENT FORNANOTECH
Publication Date
2019-08-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method of in vivo targeted ovarian cancer cell imaging nano material composed of multifunctional macromolecule and metal-organic frames (MOFs). A polymer with atargeted ovarian cancer cell polypeptide is synthesized through an RAFT reaction, and the polymer is coordinated with Eu-MOF synthesized through a solvent thermal method, so that nano particles with targeted ovarian cancer cells and an in vivo fluorescent imaging function are obtained. The fluorescent material obtained through the method has the characteristics of good biocompatibility, strong targeted performance and strong illuminating intensity. The targeted polypeptide is grated onto the polymer through the RAFT reaction, then the polymer is constructed into rare earth MOF nano particles through a coordination method, so that the MOF nano particles have both fluorescent performance and a targeting function. The preparation method of the invention is simple in technique and strong in operability, and can further meet demands of production and application.
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Description

technical field

[0001] The invention relates to a preparation method of an in vivo targeting ovarian cancer cell imaging nanomaterial composed of multifunctional polymers and metal organic frameworks (MOFs). The invention belongs to the field of nano biomedical materials. Background technique

[0002] In recent years, the synthesis of nano-rare-earth metal-organic frameworks (MOFs) materials and their applications in biomedicine, especially in tumor diagnosis and treatment, have attracted widespread attention from scientists. Known for their porosity, MOFs have been widely used in various fields, such as nonlinear optics, gas adsorption, catalysis, and chemical sensing. Due to the unique optical properties of nano-rare earth MOFs, which can be used in biological imaging, such as fluorescence imaging, the research on nano-rare earth MOFs provides a new platform for the development of new diagnostic and therapeutic integration reagents. Nevertheless, MOFs still have certain ...

Claims

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