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Shear force-responsive supramolecular bionic articular cartilage material with dynamic lubrication and self-repairing ability and preparation method thereof

A dynamic lubrication, bionic joint technology, applied in pharmaceutical formulations, tissue regeneration, medical science, etc., can solve problems such as loss of physiological lubrication function, increase in friction coefficient, and damage to the arched fiber network structure.

Active Publication Date: 2019-08-30
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, certain occupational labor, strenuous exercise, genu varus and valgus deformity, etc., cause local wear and tear on the entire joint, resulting in the destruction of the arched fiber network structure of the cartilage mechanism, increased friction coefficient, degeneration of cartilage and loss of original physiological lubrication. Function

Method used

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  • Shear force-responsive supramolecular bionic articular cartilage material with dynamic lubrication and self-repairing ability and preparation method thereof
  • Shear force-responsive supramolecular bionic articular cartilage material with dynamic lubrication and self-repairing ability and preparation method thereof
  • Shear force-responsive supramolecular bionic articular cartilage material with dynamic lubrication and self-repairing ability and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Measure 50mL of hydroxyethylacrylamide in a conical flask, then weigh 5g of monomer polyvinyl alcohol powder and add it to the above solution, add crosslinking agent glutaraldehyde and initiator ketoglutaric acid to the solution, crosslinking agent The final concentrations of the initiator and initiator are both 0.5 μg / mL, and the solution is mixed evenly by magnetic stirring (800 r / min) for 50 min.

[0020] (2) Take 40 mL of the solution prepared in step (1), add 60 mg of fluorenylmethoxycarbonyl-L-tryptophan; magnetically stir at 85°C for 3 hours to dissolve the monomer; after dissolving, cool the solution to room temperature to obtain fluorenylmethyl Oxycarbonyl-L-tryptophan concentration is 1.5mg / mL solution, the above solution is exposed to ultraviolet light for 5h to form a gel, and the surface of the sample is washed with deionized water to remove residual monomers, and the obtained hydrogel is the hydrogel described in the present invention. A shear force-respon...

Embodiment 2

[0022] (1) Measure 50mL of octylphenol polyethoxy acrylate in a conical flask, then weigh 5g of monomeric acrylamide powder and add it to the above solution, and add the crosslinking agent 1-(3-dimethylamino Propyl)-3-ethylcarbodiimide hydrochloride and initiator ketoglutaric acid, the final concentration of cross-linking agent and initiator are 30 μg / mL, magnetic stirring (rotating speed is 100r / min) 10min makes the solution well mixed.

[0023] (2) Take 40mL of the solution prepared in step (1), add 3.2g of fluorenylmethoxycarbonyl-L-tryptophan; magnetically stir at 60°C for 5h to dissolve the monomer; after dissolving, cool the solution to room temperature to obtain fluorene A solution of methoxycarbonyl-L-tryptophan with a concentration of 80mg / mL, the above solution was heated in a water bath at 60°C for 3 hours to form a gel, and the surface of the sample was washed with deionized water to remove residual monomers, and the obtained hydrogel was The shear force-responsiv...

Embodiment 3

[0025] (1) Measure 20mL of hydroxyethylacrylamide in a conical flask, then weigh 3g of monomeric acrylamide powder and add it to the above solution, and add the crosslinking agent 1-(3-dimethylaminopropyl)- 3-Ethylcarbodiimide hydrochloride and initiator ketoglutaric acid, the final concentration of crosslinking agent and initiator are both 30 μg / mL, and the solution is mixed evenly by magnetic stirring (1000 r / min) for 10 minutes.

[0026] (2) Take 40mL of the solution prepared in step (1), add 3.2g of fluorenylmethoxycarbonyl-L-tryptophan; magnetically stir at 60°C for 5h to dissolve the monomer; after dissolving, cool the solution to room temperature to obtain fluorene A solution of methoxycarbonyl-L-tryptophan with a concentration of 80mg / mL, the above solution was heated in a water bath at 60°C for 3 hours to form a gel, and the surface of the sample was washed with deionized water to remove residual monomers, and the obtained hydrogel was The shear force-responsive supra...

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Abstract

The invention relates to a shear force-responsive supramolecular bionic articular cartilage material with dynamic lubrication and self-repairing ability and a preparation method thereof, and belongs to the technical fields of bionic self-repairing and lubricating articular cartilage materials and preparation thereof. Inspired by articular cartilage, a covalently crosslinked high-strength hydrogelnetwork, a shear force-responsive supramolecular network and an intrinsic self-repairing structural motif are organically combined to provide an intelligent hydrogel material having a function of bionic articular cartilage activity. The intelligent hydrogel material has good mechanical properties and a shear self-lubricating function; more importantly, through the interaction between a shear force-responsive exudation lubricating layer and a self-repairing motif, the dynamic exudation lubrication mechanism is simulated while realizing the double repair of a three-dimensional network structureand the shear force-responsive self-lubricating function after the material is worn. The design concept can be applied to the preparation of new artificial articular cartilage or self-repairing lubrication devices, and has broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of bionic self-repairing lubricating articular cartilage material and its preparation, in particular to a shear force responsive supramolecular bionic articular cartilage material with dynamic lubricating self-repairing ability and a preparation method thereof. Background technique [0002] Articular cartilage has a fiber network structure that bears mechanical loads and a natural dynamic lubrication function, which can make joints move flexibly under certain pressure conditions to meet the needs of normal physiological activities of people. Exudative lubrication is a classic articular cartilage lubrication mechanism, that is, when the cartilage is subjected to a normal load, the lubricating matrix in the cartilage seeps out to the surface of the cartilage to form a lubricating layer. A lubricating layer will achieve super lubricating effect. We can simulate this dynamic self-lubricating process through sup...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/18A61L27/50A61L27/52C08F261/04C08F220/58C08F220/56C08F265/04C08F220/54C08F220/18C08F222/38
CPCA61L27/16A61L27/18A61L27/50A61L27/52A61L2400/10A61L2430/06A61L2430/24C08F220/18C08F220/58C08F261/04C08F265/04C08F220/1818C08F220/56C08F220/54C08F222/385
Inventor 宋文龙张雪巍
Owner JILIN UNIV
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