Shear force-responsive supramolecular bionic articular cartilage material with dynamic lubrication and self-repairing ability and preparation method thereof
A dynamic lubrication, bionic joint technology, applied in pharmaceutical formulations, tissue regeneration, medical science, etc., can solve problems such as loss of physiological lubrication function, increase in friction coefficient, and damage to the arched fiber network structure.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0019] Measure 50mL of hydroxyethylacrylamide in a conical flask, then weigh 5g of monomer polyvinyl alcohol powder and add it to the above solution, add crosslinking agent glutaraldehyde and initiator ketoglutaric acid to the solution, crosslinking agent The final concentrations of the initiator and initiator are both 0.5 μg / mL, and the solution is mixed evenly by magnetic stirring (800 r / min) for 50 min.
[0020] (2) Take 40 mL of the solution prepared in step (1), add 60 mg of fluorenylmethoxycarbonyl-L-tryptophan; magnetically stir at 85°C for 3 hours to dissolve the monomer; after dissolving, cool the solution to room temperature to obtain fluorenylmethyl Oxycarbonyl-L-tryptophan concentration is 1.5mg / mL solution, the above solution is exposed to ultraviolet light for 5h to form a gel, and the surface of the sample is washed with deionized water to remove residual monomers, and the obtained hydrogel is the hydrogel described in the present invention. A shear force-respon...
Embodiment 2
[0022] (1) Measure 50mL of octylphenol polyethoxy acrylate in a conical flask, then weigh 5g of monomeric acrylamide powder and add it to the above solution, and add the crosslinking agent 1-(3-dimethylamino Propyl)-3-ethylcarbodiimide hydrochloride and initiator ketoglutaric acid, the final concentration of cross-linking agent and initiator are 30 μg / mL, magnetic stirring (rotating speed is 100r / min) 10min makes the solution well mixed.
[0023] (2) Take 40mL of the solution prepared in step (1), add 3.2g of fluorenylmethoxycarbonyl-L-tryptophan; magnetically stir at 60°C for 5h to dissolve the monomer; after dissolving, cool the solution to room temperature to obtain fluorene A solution of methoxycarbonyl-L-tryptophan with a concentration of 80mg / mL, the above solution was heated in a water bath at 60°C for 3 hours to form a gel, and the surface of the sample was washed with deionized water to remove residual monomers, and the obtained hydrogel was The shear force-responsiv...
Embodiment 3
[0025] (1) Measure 20mL of hydroxyethylacrylamide in a conical flask, then weigh 3g of monomeric acrylamide powder and add it to the above solution, and add the crosslinking agent 1-(3-dimethylaminopropyl)- 3-Ethylcarbodiimide hydrochloride and initiator ketoglutaric acid, the final concentration of crosslinking agent and initiator are both 30 μg / mL, and the solution is mixed evenly by magnetic stirring (1000 r / min) for 10 minutes.
[0026] (2) Take 40mL of the solution prepared in step (1), add 3.2g of fluorenylmethoxycarbonyl-L-tryptophan; magnetically stir at 60°C for 5h to dissolve the monomer; after dissolving, cool the solution to room temperature to obtain fluorene A solution of methoxycarbonyl-L-tryptophan with a concentration of 80mg / mL, the above solution was heated in a water bath at 60°C for 3 hours to form a gel, and the surface of the sample was washed with deionized water to remove residual monomers, and the obtained hydrogel was The shear force-responsive supra...
PUM
Login to view more Abstract
Description
Claims
Application Information
Login to view more - R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap