A kind of glycopeptide with antidepressant function and its preparation method and application

An antidepressant and glycopeptide technology, applied in the biological field, can solve problems such as sexual dysfunction and cognitive impairment
CN110183522BActive Publication Date: 2020-09-18BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
Publication Date
2020-09-18

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Abstract

The invention discloses glycopeptide having the function of resisting depression and a preparation method and application of the glycopeptide. The glycopeptide having the function of resisting depression is from glossy ganoderma, the N-terminal sequence of the glycopeptide is as shown in a sequence 1 in a sequence table, and the glycopeptide has 4 peptide segments as shown in 1-4 in the sequence table. The glycopeptide can reduce the tail suspension fixing time of mice, reduce the swimming dead time of the mice, increase the sucrose preference ratio of depression mice, increase the level of 5-hydroxytryptamine in prefrontal cortex of the depression mice, increase the level of noradrenaline in the prefrontal cortex of the depression mice, increase the expression level of BDNF protein in theprefrontal cortex of the depression mice and reduce the content of corticosterone of the depression mice. The glycopeptide can be used for preventing and / or treating depression.
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Description

technical field

[0001] The invention relates to a glycopeptide with antidepressant function in the biological field, its preparation method and application. Background technique

[0002] Depression is one of the most common mental illnesses, defined as low mood, lack of initiative, low self-esteem, strong feelings of guilt, and suicidal tendencies, and it includes emotional, cognitive, and physical symptoms. The global disease epidemiology report shows that depression affects more than 3.5 billion people worldwide, with an estimated prevalence of 5.8% in men and 9.5% in women, and more than 10% of the world's population is experiencing emotional anxiety and The torment of chronic chronic stress.

[0003] A large amount of research data shows that the formation mechanism of depression is caused by various factors. Modern clinical treatment of depression mainly uses monoamine oxidase inhibitors, norepinephrine inhibitors and 5-hydroxytryptamine inhibitors, etc., accompanied b...

Claims

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