Double network structure macromolecule hydrogel preparation method based on full physical cross-linking

A technology of polymer hydrogel and network structure, which is applied in the field of preparation of double network structure polymer hydrogel to achieve high mechanical strength, low cost and mild preparation conditions

Inactive Publication Date: 2019-08-30
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In addition, there is no literature or patent report on the dual-network hydrogel with nano-lithiaticite / polyacrylamide as the rigid first network and polyvinyl alcohol cross-linked network as the flexible second network.

Method used

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  • Double network structure macromolecule hydrogel preparation method based on full physical cross-linking
  • Double network structure macromolecule hydrogel preparation method based on full physical cross-linking

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Experimental program
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Embodiment 1

[0036] The method for preparing a double network structure polymer hydrogel based on full physical crosslinking provided in this embodiment includes the following specific steps:

[0037] 1) Preparation of polyvinyl alcohol solution:

[0038] Add a certain amount of polyvinyl alcohol to quantitative deionized water to make the mass fraction of the solution 20wt%, and stir vigorously at 96°C for 10 hours until the polyvinyl alcohol is completely dispersed in the water to obtain a polyvinyl alcohol solution;

[0039] 2) Preparation of RDS Lithium Diatomite Dispersion:

[0040] Add 0.10g of RDS Lithium-Ionite into 10mL of water, and then ultrasonically disperse for 55 minutes until the RDS Lithium-Ionite is completely dissolved in the water;

[0041] 3) Preparation of the first network of double network hydrogel:

[0042] Add 4g of acrylamide to the RDS lithium-atomite dispersion with a mass concentration of 0.10g / 10mL prepared in step 2), stir well for 40 minutes to dissolve it in the solu...

Embodiment 2

[0047] The preparation method of the double network structure polymer hydrogel based on full physical crosslinking provided in this embodiment includes the following specific steps:

[0048] 1) Preparation of polyvinyl alcohol solution:

[0049] Add a certain amount of polyvinyl alcohol to quantitative deionized water to make the mass fraction of the solution 10wt%, and stir vigorously at 97°C for 12 hours until the polyvinyl alcohol is completely dispersed in the water to obtain a polyvinyl alcohol solution;

[0050] 2) Preparation of RDS Lithium Diatomite Dispersion:

[0051] Add 0.25g of RDS Lithium-Ionite into 6mL of water, and then ultrasonically disperse for 60 minutes until RDS Lithium-Ionite is completely dissolved in the water;

[0052] 3) Preparation of the first network of double network hydrogel:

[0053] Add 10g of acrylamide to the 0.42g / 10mL RDS Lithium Diatomite dispersion prepared in step 2), stir well for 50 minutes to dissolve it in the solution, and then slowly add it...

Embodiment 3

[0056] The preparation method of the double network structure polymer hydrogel based on full physical crosslinking provided in this embodiment includes the following specific steps:

[0057] 1) Preparation of polyvinyl alcohol solution:

[0058] Add a certain amount of polyvinyl alcohol to quantitative deionized water to make the mass fraction of the solution 15 wt%, and stir vigorously at 95°C for 8 hours until the polyvinyl alcohol is completely dispersed in the water to obtain a polyvinyl alcohol solution;

[0059] 2) Preparation of RDS Lithium Diatomite Dispersion:

[0060] Add 0.05g of RDS Lithium Oxide into 14mL of water, then ultrasonically disperse for 50 minutes until the RDS Lithium Oxide is completely dissolved in the water;

[0061] 3) Preparation of the first network of double network hydrogel:

[0062] Add 2g of acrylamide to the RDS lithium-atomite dispersion with a mass concentration of 0.036g / 10mL prepared in step 2), stir well for 30 minutes to dissolve it in the soluti...

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Abstract

The invention discloses a double network structure macromolecule hydrogel preparation method based on full physical cross-linking. According to the preparation method, a large number of the hydroxyl groups and the amide groups in a macromolecule polymer easily form hydrogen bonds, RDS sol type laponite can be used as the physical cross-linking point of a polyacrylamide network, a nanometer laponite / polyacrylamide first network is prepared through free radical polymerization, and the first network is subjected to physical cross-linking with polyvinyl alcohol through a freezing / thawing circulation method to obtain a second network, such that the polyvinyl alcohol / polyacrylamide-laponite full physical cross-linking double network hydrogel is synthesized through the two-step method. Accordingto the present invention, the method has advantages of simple operation, easy control, mild preparation condition, time and space controllability, time and space selectivity, good repeatability, environmental protection, simple equipment, low cost and the like, and has broad application prospects in the fields of drug delivery and controlled release, tissue engineering, bio-bionic, artificial muscles, biosensors and the like.

Description

Technical field [0001] The invention belongs to the fields of polymer materials, radical polymerization chemistry, and biological materials, and particularly relates to a method for preparing a double network structure polymer hydrogel based on full physical crosslinking. Background technique [0002] As a special functional polymer material with high water content, hydrogel has excellent biocompatibility and has been widely studied and applied in the fields of biomaterials, tissue engineering, biomimetic materials, smart materials, drug loading, and cell cultivation. However, in some applications, such as biomimetic materials, tissue engineering, etc., hydrogels are required to be able to withstand greater deformation and higher stress. However, general hydrogels have poor mechanical properties and are difficult to withstand large deformation or stress, which greatly limits the application and research of hydrogels in these fields. [0003] The emerging dual-network hydrogel is c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F261/04C08F220/56C08F2/44C08K3/34
CPCC08F2/44C08F261/04C08K3/34C08K2201/011C08F220/56
Inventor 陈艳军邹进成李孟洳马帅王嘉诚
Owner WUHAN UNIV OF TECH
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