Preparation method of bacterial cellulose dressing with antibiosis and bacteriostasis functions

A technology of bacterial cellulose and bacterial cellulose film, applied in the field of medical materials, can solve the problems of poor binding stability of nano-silver, limited nano-silver loading, insignificant antibacterial effect, etc., and achieve good antibacterial and bacteriostatic function and modification reaction. The degree of controllable, the effect of promoting wound healing

Inactive Publication Date: 2019-09-03
YANCHENG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] On the one hand, the loading of nano-silver in the above method is very limited, the antibacterial effect of low-dose loading is not obvious, and high-dose loading will produce obvious bioaccumulation and toxic side effects; on the other hand, the binding stability of nano-silver in bacterial cellulose is poor , easy to fall off, not long-lasting
[0006] Publication number: Chinese patent application CN104874015A discloses a bacterial cellulose dressing with antibacterial and antibacterial functions and its preparation method and application. It is loaded on the bacterial cellulose by in-situ reaction. This method uses nano ZnO is used as an antibacterial agent, but it should be noted that the distribution of bacterial cellulose structure is not uniform, so it is difficult to completely and evenly disperse in bacterial cellulose

Method used

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Examples

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Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of bacterial cellulose dressing with antibacterial and antibacterial function, said dressing comprises bacterial cellulose, chitosan and 3-aminopropyltriethoxysilane, bacterial cellulose is biomodified by chitosan Then graft 3-aminopropyltriethoxysilane, wash and dry to obtain a bacterial cellulose dressing with antibacterial and antibacterial functions; the specific preparation method comprises the following steps:

[0035] Step 1, biomodification of bacterial cellulose by chitosan:

[0036] (1) Inoculate the activated Acetobacter xylinum into the seed medium for culture, and then insert 5% of the inoculum into the fermentation medium containing 0.25 wt% chitosan, and fully shake it to make the bacteria in the seed medium Evenly dispersed in the fermentation medium, then placed in a constant temperature incubator at 28 °C, and cultured for 1 week;

[0037] (2) Take out the bacterial cellulose membrane obtained in step (1), wash off the medium and ...

Embodiment 2

[0042] A preparation method of bacterial cellulose dressing with antibacterial and antibacterial function, said dressing comprises bacterial cellulose, chitosan and 3-aminopropyltriethoxysilane, bacterial cellulose is biomodified by chitosan Then graft 3-aminopropyltriethoxysilane, wash and dry to obtain a bacterial cellulose dressing with antibacterial and antibacterial functions; the specific preparation method comprises the following steps:

[0043] Step 1, biomodification of bacterial cellulose by chitosan:

[0044] (1) Inoculate the activated Acetobacter xylinum into the seed medium for culture, and then insert 6% of the inoculum into the fermentation medium containing 0.5 wt% chitosan, and fully shake it to make the bacteria in the seed medium Evenly dispersed in the fermentation medium, then placed in a constant temperature incubator at 28 °C, and cultured for 2 weeks;

[0045] (2) Take out the bacterial cellulose membrane obtained in step (1), wash off the medium and ...

Embodiment 3

[0050] A preparation method of bacterial cellulose dressing with antibacterial and antibacterial function, said dressing comprises bacterial cellulose, chitosan and 3-aminopropyltriethoxysilane, bacterial cellulose is biomodified by chitosan Then graft 3-aminopropyltriethoxysilane, wash and dry to obtain a bacterial cellulose dressing with antibacterial and antibacterial functions; the specific preparation method comprises the following steps:

[0051] Step 1, biomodification of bacterial cellulose by chitosan:

[0052] (1) Inoculate the activated Acetobacter xylinum into the seed medium for culture, and then insert 7% of the inoculum into the fermentation medium containing 0.75 wt% chitosan, shake fully to make the bacteria in the seed medium Evenly dispersed in the fermentation medium, then placed in a constant temperature incubator at 28 °C, and cultured for 1 week;

[0053] (2) Take out the bacterial cellulose membrane obtained in step (1), wash off the medium and impurit...

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Abstract

The invention discloses a preparation method of a bacterial cellulose dressing with antibiosis and bacteriostasis functions. The dressing comprises bacterial cellulose, chitosan and 3-aminopropyltriethoxysilane, and the bacterial cellulose is biologically modified by chitosan and then grafted with 3-aminopropyltriethoxysilane, and the material is washed and dried to obtain the bacterial cellulosedressing having antibiosis and bacteriostasis functions. The method adopts the biological modification and a chemical grafting method to impart excellent antibiosis and bacteriostasis functions to thebacterial cellulose dressing, and avoids the use of a nano silver material with latent risk, and the use of chitosan and 3-aminopropyltriethoxysilane with certain healing and auxiliary treatment as antibiosis and bacteriostasis materials provides a good effect on the field of wound dressing. The dressing obtained by the invention has the advantages of long antibacterial time, simple process, easyindustrialization, and is suitable for popularization and use.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a preparation method of a bacterial cellulose dressing with antibacterial and antibacterial functions. Background technique [0002] The skin is the largest organ in the whole body, accounting for about 16% of the body weight. It plays a role in regulating body temperature, maintaining body image and immunity. Wounds are formed when the skin is damaged due to external force or pathological reasons. Medical dressing is an important medical material that protects wounds, relieves pain, and promotes wound healing. According to different shapes and sources, medical dressings generally include (a) common gauze or gauze strips; (b) hydrocolloid dressings; (c) hydrogel dressings; (d) alginate dressings. [0003] Bacterial Cellulose is a natural polymer secreted by microorganisms such as Acetobacter, Bacillus, Agrobacterium, and Rhizobium. BC is a nano-polymer material pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/28A61L15/20
CPCA61L15/20A61L15/28A61L15/46A61L2300/216A61L2300/232A61L2300/404A61L2300/412C08L1/02C08L5/08
Inventor 王丽丽高大伟蒋文斌陆云芳周亲雄
Owner YANCHENG INST OF TECH
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