Hair growth composition

A composition and active substance technology, applied in hair care, cosmetics, cosmetic preparations and other directions, can solve the problems of difficulty in nutrients and difficult to fully exert their effects, and achieve the effects of promoting cell activation, enhancing hair follicle function, and enhancing absorption.

Active Publication Date: 2019-09-06
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of large side effects and poor effects of existing hair growth and anti-hair loss cosmetics, the present invention provides a hair growth composition with remarkable hair growth effect, and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1 The anti-inflammatory effect of different ratios of blue copper peptide and procyanidin B2

[0025] The blue copper peptide and proanthocyanidin B2 were prepared in the culture medium according to the mass ratio of 1:0, 0:1, 4:1, 2:1, 1:1, 1:2, 1:4, 1:8, and 1:10 For the total content of 1, 2, 5, 10 and 20μg / mL solution, filter sterilization for use. 3T3 mouse embryonic fibroblasts in log phase are used as test materials and added to 96-well culture plate, and 0.1 mL per well is added at a density of 1×10 5 Cells / mL cell suspension, culture until adherence, discard the culture medium, add 0.1mL lipopolysaccharide (LPS) physiological saline solution or physiological saline (blank control) with a concentration of 1μg / mL, and then add 0.1mL respectively The blue copper peptide and proanthocyanidin B2 solution, with LPS only as a positive control, cultured for 24h, aspirate the culture medium, centrifuged and take the supernatant for ELISA to detect the inflammatory ...

Example Embodiment

[0031] Example 2 Preparation of hair growth composition

[0032] Weigh the raw materials according to the following ratio:

[0033]

Example Embodiment

[0034] Example 3 Repair effect

[0035] The hair growth composition in Example 2 was prepared as a 2% solution with the culture solution, and filtered and sterilized for later use. Using L929 mouse fibroblasts as the test material, add 0.1 mL of cell density to a 96-well culture plate at a density of 5×10 4 Cells / mL of L929 cell suspension, then add 0.1mL of different hair growth composition solutions, continue to culture the cells for 24h, use the wells with only the culture medium as the blank control, and the cell suspension only as the negative control, each treatment 5 Repeat the hole, use the MTT method to determine the absorbance value, and calculate the cell proliferation rate according to the following formula:

[0036] .

[0037] Table 2 Effect on cell proliferation rate

[0038]

[0039] According to the data in Table 2, compared with the hair growth composition without adding hydrolyzed hyaluronic acid and Centella asiatica extract, the addition of hydrolyzed hyaluronic ...

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Abstract

The invention provides a hair growth composition, which comprises the following raw materials in parts by mass: 15-30 parts of hydrolyzed hyaluronic acid, 15-20 parts of centella asiatica extracts, 10-50 parts of procyanidins B2 and 5-10 parts of blue copper peptide. The molecular weight of the hydrolyzed hyaluronic acid is 8K-10KDa; and the mass ratio of the blue copper peptide to the anthocyaninB2 is 1: 1-10. The hair growth composition can mildly remove dandruff, inhibit oil secretion, balance scalp biological flora, inhibit alopecia, repair hair follicles and stimulate new hair growth under the combined action of several substances.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to a hair growth composition, in particular to a composition containing centella asiatica extract, proanthocyanidin B2, blue copper peptide and hydrolyzed hyaluronic acid. Background technique [0002] Alopecia is a common disease and frequently-occurring disease in dermatology. In addition to alopecia, patients are often accompanied by symptoms such as scalp itching and increased dandruff, which seriously affect daily life and work. And regardless of gender, age, personal appearance will be affected, and it will affect the mental health of patients over time. The causes of hair loss are complex and diverse, which can be roughly classified into the following categories: mental factors such as excessive mental stress and nervous tension; imbalance of sex hormone secretion or genetic factors; side effects of drugs such as immunosuppressants and chemotherapy drugs; Factors in nutritional metabol...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/64A61K8/73A61K8/9789A61Q7/00
CPCA61K8/735A61K8/9789A61K8/498A61K8/64A61Q7/00A61K2800/592
Inventor 范馨仪王玉玲刘建建陈衍玲徐松堂郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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