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Hair growth composition

A composition and active substance technology, applied in hair care, cosmetics, cosmetic preparations and other directions, can solve the problems of difficulty in nutrients and difficult to fully exert their effects, and achieve the effects of promoting cell activation, enhancing hair follicle function, and enhancing absorption.

Active Publication Date: 2019-09-06
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of large side effects and poor effects of existing hair growth and anti-hair loss cosmetics, the present invention provides a hair growth composition with remarkable hair growth effect, and can solve the problem that active substances and nutrients are difficult to be absorbed by the scalp, and it is difficult to fully exert their effects. And other problems, and no side effects, the effect is remarkable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Anti-inflammatory effect of different ratios of blue copper peptide and proanthocyanidin B2

[0025] Prepare blue copper peptide and proanthocyanidin B2 in culture solution according to the mass ratio of 1:0, 0:1, 4:1, 2:1, 1:1, 1:2, 1:4, 1:8, 1:10 For solutions with a total content of 1, 2, 5, 10 and 20 μg / mL, filter and sterilize for later use. Add 3T3 mouse embryonic fibroblasts in the logarithmic phase to a 96-well culture plate as the test material, add 0.1mL to each well at a density of 1×10 5 cells / mL cell suspension, cultivated until adherent, discarded the culture medium, added 0.1mL lipopolysaccharide (LPS) normal saline solution or normal saline (blank control) with a concentration of 1μg / mL, and then added 0.1mL respectively to prepare The blue copper peptide and proanthocyanidin B2 solution, with only LPS added as a positive control, after 24 hours of culture, absorb the culture solution, centrifuge and take the supernatant to detect the inflamma...

Embodiment 2

[0031] Example 2 Preparation of hair growth composition

[0032] Weigh raw materials according to the following proportions:

[0033]

Embodiment 3

[0034] Example 3 Restoration effect

[0035] The hair growth composition in Example 2 was prepared as a 2% solution with culture fluid, and filtered and sterilized for subsequent use. Using L929 mouse fibroblasts as the test material, add 0.1mL cell density to 5×10 4 cells / mL of L929 cell suspension, then add 0.1mL of different hair growth composition solutions, continue to culture cells for 24h, take the wells only added with culture solution as the blank control, and the wells only added with the cell suspension as the negative control, 5 wells per treatment Duplicate wells, the absorbance value was measured by MTT method, and the cell proliferation rate was calculated according to the following formula:

[0036] .

[0037] Table 2 Effects on cell proliferation rate

[0038]

[0039] As can be seen from the data in Table 2, compared with the hair growth composition without adding hydrolyzed hyaluronic acid and Centella asiatica extract, adding hydrolyzed hyaluronic a...

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Abstract

The invention provides a hair growth composition, which comprises the following raw materials in parts by mass: 15-30 parts of hydrolyzed hyaluronic acid, 15-20 parts of centella asiatica extracts, 10-50 parts of procyanidins B2 and 5-10 parts of blue copper peptide. The molecular weight of the hydrolyzed hyaluronic acid is 8K-10KDa; and the mass ratio of the blue copper peptide to the anthocyaninB2 is 1: 1-10. The hair growth composition can mildly remove dandruff, inhibit oil secretion, balance scalp biological flora, inhibit alopecia, repair hair follicles and stimulate new hair growth under the combined action of several substances.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to a hair growth composition, in particular to a composition containing centella asiatica extract, proanthocyanidin B2, blue copper peptide and hydrolyzed hyaluronic acid. Background technique [0002] Alopecia is a common disease and frequently-occurring disease in dermatology. In addition to alopecia, patients are often accompanied by symptoms such as scalp itching and increased dandruff, which seriously affect daily life and work. And regardless of gender, age, personal appearance will be affected, and it will affect the mental health of patients over time. The causes of hair loss are complex and diverse, which can be roughly classified into the following categories: mental factors such as excessive mental stress and nervous tension; imbalance of sex hormone secretion or genetic factors; side effects of drugs such as immunosuppressants and chemotherapy drugs; Factors in nutritional metabol...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/64A61K8/73A61K8/9789A61Q7/00
CPCA61K8/735A61K8/9789A61K8/498A61K8/64A61Q7/00A61K2800/592
Inventor 范馨仪王玉玲刘建建陈衍玲徐松堂郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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