Silk fibroin/silver phosphate nano-wire composite pore channel scaffold, construction method and applications thereof

A silk fibroin, composite pore technology, applied in chemical instruments and methods, chemical/physical processes, physical/chemical process catalysts, etc., can solve the problem that the pore scaffold cannot control the microstructure and morphology, and achieve the regulation of the microstructure and morphology. , Expand the effect of the application

Active Publication Date: 2019-09-06
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved by the present invention is: the existing pore scaffolds cannot regulate the microstructure morphology, and a silk fibroin / silver phosphate nanowire composite pore scaffold, construction method and application are provided.

Method used

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  • Silk fibroin/silver phosphate nano-wire composite pore channel scaffold, construction method and applications thereof
  • Silk fibroin/silver phosphate nano-wire composite pore channel scaffold, construction method and applications thereof
  • Silk fibroin/silver phosphate nano-wire composite pore channel scaffold, construction method and applications thereof

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Effect test

Embodiment 1

[0044] This embodiment provides a method for constructing a silk fibroin / silver phosphate nanowire composite pore scaffold, which includes the following steps:

[0045] First prepare a silk fibroin-silver nitrate mixed solution, where the concentration of silk fibroin is 4%, the concentration of silver nitrate is 2%, and the mass ratio of silk fibroin to silver nitrate is 2:1. See the picture of the mixed solution figure 1 ;

[0046] Pour the mixed solution into a mold placed horizontally on a metal plate at -15°C. After fully freezing, transfer the obtained ice cubes to a freeze dryer for drying. After the ice crystals sublimate, the white porous solid obtained is silk fibroin. Protein-oriented channel scaffold, freezing temperature affects the pore size, see the photo of the oriented channel scaffold figure 2 ;

[0047] The above-mentioned oriented porous scaffold is placed in a phosphoric acid solution with a surfactant PAA concentration of 0.2 mg / ml, wherein the phosphoric acid ...

Embodiment 2

[0056] This embodiment provides a method for constructing a silk fibroin / silver phosphate nanowire composite pore scaffold, which includes the following steps:

[0057] Prepare a silk fibroin-silver nitrate mixed solution, where the silk fibroin concentration is 4%, the silver nitrate concentration is 4%, and the mass ratio of silk fibroin to silver nitrate is 1:1;

[0058] Pour the mixed solution into a mold placed horizontally on a metal plate at -5°C. After fully freezing, transfer the obtained ice cubes to a freeze dryer for drying. After the ice crystals sublimate, the white porous solid obtained is silk fibroin. Protein-oriented channel scaffold;

[0059] The above-mentioned oriented porous scaffold is placed in a phosphoric acid solution with a surfactant PAA concentration of 0.25 mg / ml. The phosphoric acid solution uses a mixture of methanol and water as the solvent, and the mass ratio of methanol to water is 90:10. The mass volume ratio concentration is 2.6mg / ml, and the re...

Embodiment 3

[0065] This embodiment provides a method for constructing a silk fibroin / silver phosphate nanowire composite pore scaffold, which includes the following steps:

[0066] Prepare a silk fibroin-silver nitrate mixed solution, where the silk fibroin concentration is 4%, the silver nitrate concentration is 2%, and the mass ratio of silk fibroin to silver nitrate is 2:1;

[0067] Pour the mixed solution into a mold placed horizontally on a metal plate at -80°C. After fully freezing, transfer the resulting ice cubes to a freeze dryer for drying. After the ice crystals sublimate, the white porous solid obtained is silk fibroin. Protein-oriented channel scaffold;

[0068] The above-mentioned oriented porous scaffold is placed in a phosphoric acid solution with a surfactant PAA concentration of 0.15 mg / ml, wherein the phosphoric acid solution uses ethanol as the solvent, and the mass volume ratio of the phosphoric acid solution is 2.6 mg / ml. The reaction product is obtained by reacting for 4 h...

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Abstract

The invention discloses a silk fibroin/silver phosphate nano-wire composite pore channel scaffold, a construction method and applications thereof. The preparation method comprises: mixing a silk fibroin solution with a mass percentage concentration of 3-4% and a silver nitrate solution with a mass percentage concentration of 0.5-4% to obtain a mixed solution; freezing the mixed solution, and carrying out low-temperature drying to obtain a silk fibroin oriented pore channel scaffold; adding PAA with a mass volume ratio of 0.15-0.25 mg/ml to a phosphoric acid solution to prepare a reaction solution, placing the silk fibroin oriented pore channel scaffold in the reaction solution, and carrying out a reaction for 0.1-4 h to obtain a reaction product; and freezing the reaction product, and drying at a low temperature to obtain the silk fibroin/silver phosphate nano-wire composite pore channel scaffold. According to the present invention, the silk fibroin/silver phosphate nano-wire compositepore channel scaffold can be used as the carrier of silver phosphate nanometer materials, and during the preparation, the preparation parameters can be adjusted according to the progress of the reaction so as to adjust the morphology and the density of the in-situ growing silver phosphate nanometer crystal.

Description

Technical field [0001] The invention belongs to the technical field of organic / inorganic composite material preparation, and particularly relates to a silk fibroin / silver phosphate nanowire composite pore support, a construction method and an application. Background technique [0002] Photocatalyst refers to a chemical substance that can play a catalytic role under the excitation of photons. Nano-silver phosphate is a highly active photocatalyst. It can absorb visible light and has strong oxidizing ability and catalytic degradation performance. Adjusting the morphology of nano-silver phosphate is of great significance for optimizing its performance. Among them, the one-dimensional nanowire structure has a high aspect ratio and specific surface area, which is one of the hotspots in the controllable synthesis of nanomaterials. For the control of nano silver phosphate morphology, the difficulty lies in controlling the speed of nucleation and growth of silver phosphate crystals. Gene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J27/18C02F1/50
CPCB01J27/1817B01J35/004C02F1/50
Inventor 陆杨薛敬哲钱坤煜王湘颖王倩
Owner HEFEI UNIV OF TECH
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