The invention belongs to the field of
surface modification of biological
implant materials, and particularly relates to a method for in-situ construction of
metal organic framework nanoparticles on the surface of
titanate. The method comprises the following steps that
titanium alloy is subjected to alkali heat treatment, and a
titanate structure with a special shape is formed on the surface of the
titanium alloy; and on the basis, Zn<2+> ions are adsorbed in
titanate by utilizing the interlayer cation loading capacity of the titanate, a 2-methylimidazole ligand is dropwise added on the surface of the titanate, a growth environment of the
metal organic framework nanoparticles is provided, and the
metal organic framework nanoparticles controllably grow on titanate fibers in situ by regulating and controlling the concentration of a
solvent and the ligand. The
metal organic framework nanoparticles prepared by the method tightly wrap the titanate fibers, the original
nanofiber structure of the titanate is reserved, the
nanostructure morphology of the titanate can be enriched, the large specific surface area of the
metal organic framework nanoparticles and the titanate structure can be used as a loading platform of two different systems, and the intelligent
medicine carrying function is realized.