Method for in-situ construction of metal organic framework nanoparticles on surface of titanate

A metal-organic framework, nanoparticle technology, applied in the fields of nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve sensitization reactions, the corrosion resistance of metal biomaterials is not ideal, and it cannot actively induce new Bone and other problems to achieve the effect of improving surface bioactivity, optimizing loading capacity, improving surface hydrophobicity and surface roughness

Active Publication Date: 2021-12-03
CHANGZHOU UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the metal materials currently used clinically are biologically inert materials, and their surfaces cannot actively induce the formation of new bone, resulting in the formation of fibrous capsules between the implant and bone tissue, reducing the interface bonding strength between the bone and the implant, thus cause early failure of the implant
In addition, the corrosion resistance of metal biomaterials is not ideal, and harmful metal ions will be released in the human body, causing inflammation and sensitization, affecting the long-term safety of implant materials

Method used

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  • Method for in-situ construction of metal organic framework nanoparticles on surface of titanate
  • Method for in-situ construction of metal organic framework nanoparticles on surface of titanate
  • Method for in-situ construction of metal organic framework nanoparticles on surface of titanate

Examples

Experimental program
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Effect test

Embodiment 1

[0039] (1) Preparation of nano titanate structure by alkali heat treatment

[0040] The substrate used this time is Ti-6Al-4V titanium alloy. A Ti-6Al-4V titanium alloy substrate with a size of 15mm×15mm×0.5mm was prepared. Put the titanium alloy matrix into a polytetrafluoroethylene dish with a capacity of 30ml, and use a mixed acid diluted 15 times (the volume ratio is HF:HNO 3 : deionized water = 3:2:10) Soak the titanium alloy for 2 minutes, then rinse it with deionized water, then place it in deionized water, and perform ultrasonic cleaning for 5 minutes to remove impurities and oil stains on the titanium alloy substrate. After the ultrasound is completed, dry the cleaned titanium alloy substrate with a hair dryer, and put it into a Teflon liner with a capacity of 100ml. According to the size of the titanium alloy substrate and Teflon, there is no stacking in each Teflon liner. Insert 7 cleaned titanium alloy substrates, mark the front and back sides, and face up.

[0...

Embodiment 2

[0047] (1) titanate is prepared with embodiment 1;

[0048] (2) During the cation exchange process, the ion exchange time was changed to 1 h by titanate immersion, and other parameters and steps were the same as in Example 1;

[0049] (3) In-situ growth of ZIF-8 nanoparticles between titanate layers is the same as in Example 1.

[0050] The result is as figure 2 As shown in c, ZIF-8 particles grown in situ can still be prepared by changing the cation exchange time.

Embodiment 3

[0052] (1) titanate is prepared with embodiment 1;

[0053] (2) in the cation exchange process, the concentration of zinc nitrate hexahydrate becomes 0.1M by 0.5M, and other parameters and steps are with embodiment 1;

[0054] (3) In-situ growth of ZIF-8 nanoparticles between titanate layers is the same as in Example 1.

[0055] The result is as figure 2 As shown in d, ZIF-8 particles grown in situ can still be prepared by reducing the concentration of the cation exchange solution.

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Abstract

The invention belongs to the field of surface modification of biological implant materials, and particularly relates to a method for in-situ construction of metal organic framework nanoparticles on the surface of titanate. The method comprises the following steps that titanium alloy is subjected to alkali heat treatment, and a titanate structure with a special shape is formed on the surface of the titanium alloy; and on the basis, Zn<2+> ions are adsorbed in titanate by utilizing the interlayer cation loading capacity of the titanate, a 2-methylimidazole ligand is dropwise added on the surface of the titanate, a growth environment of the metal organic framework nanoparticles is provided, and the metal organic framework nanoparticles controllably grow on titanate fibers in situ by regulating and controlling the concentration of a solvent and the ligand. The metal organic framework nanoparticles prepared by the method tightly wrap the titanate fibers, the original nanofiber structure of the titanate is reserved, the nanostructure morphology of the titanate can be enriched, the large specific surface area of the metal organic framework nanoparticles and the titanate structure can be used as a loading platform of two different systems, and the intelligent medicine carrying function is realized.

Description

technical field [0001] The invention belongs to the field of surface modification of biological implant materials, and in particular relates to a method for in-situ construction of metal-organic framework nanoparticles on the surface of titanate. Background technique [0002] Metal implant materials have been widely used in the treatment of various hard tissue-related diseases, but the lack of osseointegration and antibacterial ability of the surface of metal implants often leads to clinical implant surgery failure. Surface modification can specifically improve the surface properties of metal materials while maintaining their excellent mechanical properties, and is currently widely used to solve the problems of poor osseointegration and lack of antibacterial properties in metal implants. Titanium and its alloys have an elastic modulus close to that of natural bone in the human body, and are currently the most widely used clinically. However, the metal materials currently us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C26/00A61L27/06A61L27/30A61L27/50A61L27/54B82Y5/00B82Y30/00B82Y40/00
CPCC23C26/00A61L27/06A61L27/306A61L27/54A61L27/50B82Y5/00B82Y30/00B82Y40/00A61L2400/12A61L2300/102A61L2300/404A61L2300/606
Inventor 赵晓兵吴犇
Owner CHANGZHOU UNIV
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