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High-strength absorbable active composite material and preparation method thereof

A technology of composite materials and polymers, applied in medical science, surgery, etc., can solve the problems of brittle limitation, poor mechanical strength of polylactic acid, and reduced material strength, and achieve the effect of improving surface properties and mechanical properties

Pending Publication Date: 2020-11-10
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The relatively poor mechanical strength and inherent brittleness of PLA undoubtedly limit its application in the field of biomedical materials.
So far, various strategies have been used to toughen PLA, such as adding plasticizers, blending, copolymerization and other modification methods, but these solutions usually lead to a decrease in the strength of the material

Method used

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  • High-strength absorbable active composite material and preparation method thereof
  • High-strength absorbable active composite material and preparation method thereof
  • High-strength absorbable active composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Synthesis of degradable polymer polylactic acid (PLA)-1% modified nano-hydroxyapatite (SHA) nanocomposites

[0040] Nano-hydroxyapatite particles with an aspect ratio of 5.5 were prepared by chemical precipitation method:

[0041] Prepare Ca(NO 3 ) 2 4H 2 O aqueous solution and (NH 4 ) 2 HPO 4 aqueous solution, the Ca / P molar ratio is controlled to be 1.67; then the Ca(NO 3 ) 2 4H 2 O aqueous solution was added (NH 4 ) 2 HPO 4 Solution, control the pH value of the reaction within the range of 10-12, control the reaction temperature to 100°C, stop the reaction after 2 hours of reaction, vacuum filter the reaction solution, and wash the filter cake alternately with deionized water and ethanol After suction filtration for 3-4 times, the filter cake was freeze-dried for 24 hours to obtain nano-hydroxyapatite particles (HA).

[0042] SHA nanoparticles were prepared by modifying hydroxyapatite with silane coupling agent 3-aminopropyltriethoxysilane (APTES):

[00...

Embodiment 2

[0047] Preparation of Synthetic Degradable Polymer Polylactic Acid (PLA)-1% Nano-Hydroxyapatite (HA) Nanocomposite

[0048] Nano-hydroxyapatite (HA) particles with an aspect ratio of 5.5 were prepared by chemical precipitation method:

[0049] Prepare Ca(NO 3 ) 2 4H 2 O aqueous solution and (NH 4 ) 2 HPO 4 aqueous solution, the Ca / P molar ratio is controlled to be 1.67; then the Ca(NO 3 ) 2 4H 2 O aqueous solution was added (NH 4 ) 2 HPO 4 Solution, control the pH value of the reaction in the range of 10-12, control the reaction temperature to 100°C, stop the reaction after 2 hours of reaction, vacuum filter the reaction solution, and wash the filter cake alternately with deionized water and ethanol After suction filtration for 3-4 times, the filter cake was freeze-dried for 24 hours to obtain nano-hydroxyapatite particles (HA).

[0050] The lactide monomer that takes 50g is in there-necked flask, adds 0.325wt% stannous octoate (Sn(Oct) 2 ) catalyst and unmodified...

Embodiment 3

[0058] Preparation of Synthetic Degradable Polymer Polylactic Acid-1% Modified Graphene Oxide (SGO) Composite

[0059] Graphene oxide (GO) was prepared by the Hummer method:

[0060] First mix 5g graphite with 2g NaNO 3 Disperse in 120mL concentrated H 2 Stir in an ice bath after SO, add 20g KMnO4 after 60min and wait for 60min to react, then transfer to a warm water bath at 30°C and continue to react for 30min, then slowly add 250mL deionized water, and keep the reaction temperature at 90°C, add an appropriate amount of h 2 o 2 Until no bubbles are generated, filter while hot, wash with deionized water and 5% hydrochloric acid several times until neutral, and dry in a vacuum oven at 60°C after centrifugation to obtain graphite oxide.

[0061] SGO nanospheres were prepared by modifying graphene oxide with silane coupling agent (APTES):

[0062] Weigh 400 mg of graphene oxide and disperse it into 200 mL of anhydrous toluene, stir at 600 rpm for 2 h, then add 800 μL of APTE...

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Abstract

The invention provides a high-strength absorbable active composite material and a preparation method thereof. The composite material is formed by compounding nanoparticles and a degradable polymer, wherein the nanoparticles are selected from one or combination of two of calcium phosphate-based nanoparticles, magnesium sulfate nanoparticles, calcium phosphate nanoparticles, calcium sulfate nanoparticles, bioactive glass nanoparticles, ferroferric oxide nanoparticles, hectorite nanoparticles, graphene oxide nanoparticles, gold nanoparticles, silver nanoparticles, silicon dioxide nanoparticles, titanium dioxide nanoparticles and silicon carbide nanoparticles; and the degradable polymer is selected from one or a mixture or a copolymer of two or more of polyglycolide, polylactic acid, polycaprolactone, poly (trimethylene carbonate), polyglycolic acid and polydioxane ketone. By introducing the nanoparticles, the surface property and the biological activity of the material are effectively improved, the mechanical property of the degradable polymer is improved, and the high-strength absorbable active composite material can be applied to preparation of absorbable fracture internal fixationdevices.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a high-strength absorbable active composite material and a preparation method thereof. Background technique [0002] Internal fixation devices are commonly used for treatment in orthopedics. The sharp ends of the internal bone fixation devices made of metal are easy to injure tissues, and will cause stress shielding due to excessive local shear stress and eventually cause nonunion; at the same time, some metal Elements may be known for their allergic reactions and even carcinogenicity. Moreover, the fixator made of metal material is also unfavorable for postoperative related examinations, which in turn affects the follow-up observation of the surgical effect. Most importantly, for the fracture internal fixation device made of metal material, all will go through the process of secondary operation to take it out, so that the patient suffers again. [0003] Polylactic acid has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/02A61L31/06
CPCA61L31/148A61L31/14A61L31/028A61L31/06C08L67/04
Inventor 刘昌胜李玉林王雅琪
Owner EAST CHINA UNIV OF SCI & TECH
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