Preparation method of antibacterial chitosan quaternary ammonium salt and product

A technology of quaternary ammonium salt and antibacterial shell, which is applied in the field of preparation of antibacterial chitosan quaternary ammonium salt, can solve the problems of cytotoxic hemolysis and poor biocompatibility, and achieve good biocompatibility, low biocompatibility, The effect of improving the antibacterial effect
CN110240664AActive Publication Date: 2019-09-17BEIJING UNIV OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING UNIV OF CHEM TECH
Publication Date
2019-09-17

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Abstract

The invention provides a preparation method of an antibacterial chitosan quaternary ammonium salt. The preparation method comprises the following steps: 1) preparing a chitosan solution; 2) adding a long alkyl chain epoxy quaternary ammonium salt and a short alkyl chain quaternary ammonium salt, and carrying out a reaction; and 3) settling the reaction liquid of the step 2), and carrying out washing and drying, so as to obtain a product. As the long alkyl chain epoxy quaternary ammonium salt and the short alkyl chain quaternary ammonium salt are cografted on chitosan, antibacterial chitosan has intensive electropositivity, and can be well combined with a bacterial membrane with negative electricity, and thus an antibacterial effect can be improved. The cografting ratio of the two components is optimized and adjusted, so that the biocompatibility of the antibacterial chitosan can be effectively improved while an antibacterial effect is ensured
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Description

technical field

[0001] The invention belongs to the field of antibacterial materials, and relates to a preparation method and product of antibacterial chitosan quaternary ammonium salt. Background technique

[0002] Chitosan is the product of deacetylation of chitin. Because of its renewability, good biocompatibility and many unique physiological and pharmacological functions, it is widely used in medicine, food, daily chemical, textile, agriculture and other fields. Its application and development prospects are broad. The Chinese invention patent publication with the publication number CN101929074A discloses a preparation method of chitosan quaternary ammonium salt, which is characterized in that a C4-18 alkyl dimethyl tertiary amine is used to react with epichlorohydrin to obtain a chitosan quaternary ammonium salt. Long alkyl chain epoxy quaternary ammonium salt, and then use long alkyl chain epoxy quaternary ammonium salt to undergo epoxy ring-opening reaction with chit...

Claims

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