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A kind of preparation method using shell as raw material nanometer calcium citrate

A technology of calcium citrate and citric acid, which is applied in the field of preparation of nanomaterials, can solve the problems of uneven particle size of calcium citrate nanoparticles, influence on the absorption of calcium citrate, and high cost, and achieve improved solubility, low cost, and reagents little effect

Active Publication Date: 2021-10-15
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the particle size of calcium citrate nanoparticles prepared by this method is relatively uneven, and the maximum size width is 700nm, which is close to the micron level, which affects the absorption of calcium citrate, and it uses calcium salt as a raw material, and the cost is relatively high.

Method used

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  • A kind of preparation method using shell as raw material nanometer calcium citrate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1) Pretreatment of shells: Obtain discarded shells, wash them with clean water for several times until there is no obvious attachment, smash the shells into small pieces, put them into a powder machine after drying, and crush them into small particles that can pass through a 50-mesh sieve. Weigh 1kg, spare.

[0046] 2) Preparation of calcium citrate: add pure water at 50°C, let stand for 30 minutes, then add food-grade citric acid, the addition ratio is shell: citric acid: water = 1:2:5 (respectively 1kg of shells, citric acid 2L, water 5L), stirred slowly, and reacted for 3 hours until there were no bubbles. Filter to obtain a solution containing calcium citrate, and set aside.

[0047] 3) Preparation of nano-calcium citrate: adjust the pH of the calcium citrate solution to 8.5 with dilute citric acid solution, let the calcium citrate solution stand and cool down to room temperature, at this time, the calcium citrate is being precipitated, and quickly add the compound...

Embodiment 2

[0054] 1) Pretreatment of shells: Obtain discarded shells, wash them with clean water for several times until there is no obvious attachment, smash the shells into small pieces, put them into a powder machine after drying, and crush them into small particles that can pass through a 50-mesh sieve. Weigh 1kg, spare.

[0055] 2) Preparation of calcium citrate: add pure water at 60°C, let stand for 30 minutes, then add food-grade citric acid, the addition ratio is shell: citric acid: water = 1:2:5 (respectively 1kg of shells, citric acid 2L, water 5L), stirred slowly, and reacted for 3 hours until there were no bubbles. Filter to obtain a solution containing calcium citrate, and set aside.

[0056] 3) Preparation of nano-calcium citrate: adjust the pH of the calcium citrate solution to 8.0 with dilute citric acid solution, let the calcium citrate solution stand and cool down to room temperature. % (containing sodium carboxymethylcellulose 1.5g, Tween 80 14.6g and ethanol 2.5ml),...

Embodiment 3

[0062] 1) Pretreatment of shells: Obtain discarded shells, wash them with clean water for several times until there is no obvious attachment, smash the shells into small pieces, put them into a powder machine after drying, and crush them into small particles that can pass through a 50-mesh sieve. Weigh 1kg, spare.

[0063] 2) Preparation of calcium citrate: add pure water at 65°C, let stand for 30 minutes, then add food-grade citric acid, the addition ratio is shell: citric acid: water = 1:2:5 (respectively 1kg of shells, citric acid 2L, water 5L), stirred slowly, and reacted for 3 hours until there were no bubbles. Filter to obtain a solution containing calcium citrate, and set aside.

[0064] 3) Preparation of nano-calcium citrate: adjust the pH of the calcium citrate solution to 8.0 with dilute citric acid solution, let the calcium citrate solution stand and cool down to room temperature. % (containing sodium carboxymethylcellulose 3.3g, Tween 80 1.3g and ethanol 0.5ml), ...

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Abstract

The invention discloses a preparation method of nanometer calcium citrate using shells as raw materials. In the present invention, waste shells and citric acid are acidified and reacted in an appropriate ratio to generate calcium citrate, and an appropriate amount of surfactant is added to control its particle size and crystal growth rate to make a lemon with nanometer size and food grade purity. Calcium acid powder. The product prepared by the method of the invention can be directly used as food additive, functional health food, beverage and feed additive or even medicine, and the production process is friendly to the environment, simple and convenient, does not require expensive equipment, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanomaterials, in particular to a preparation method of nanometer calcium citrate using shells as raw materials. Background technique [0002] my country is rich in fishery resources, among which shellfish occupy an important position in my country's fishery industry, but there is a large amount of waste such as shells, which are piled up like mountains, and the organic matter in them rots and smells during the long-term process, resulting in environmental pollution and waste of calcium resources. . [0003] Calcium deficiency is common in human beings, and Chinese people are even more calcium deficient because their diet is mainly hot food. It has been an important goal for scientists at home and abroad to develop calcium supplements with high absorption rate and no side effects for many years. It plays an extremely important role in human health, physical development of children and vari...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/41C07C59/265A23L33/16
CPCA23V2002/00A23L33/16C07B2200/13C07C51/412C07C59/265A23V2200/30A23V2250/1578
Inventor 丁玉庭杨邦伟徐霞蔡燕萍刘书来刘建华周绪霞
Owner ZHEJIANG UNIV OF TECH