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Application of flavonoid small molecule compound in preparing drug for inhibiting pancreatic lipase activity

A small molecule compound, pancreatic lipase technology, applied in the application field of obesity prevention, can solve the problem of no report of eriodictyol pancreatic lipase active drug, and achieve the effect of inhibiting pancreatic lipase activity and slowing down digestion and absorption

Inactive Publication Date: 2019-09-24
LIAONING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the application of eriodictyol in the preparation of drugs for inhibiting pancreatic lipase activity has not been reported yet.

Method used

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  • Application of flavonoid small molecule compound in preparing drug for inhibiting pancreatic lipase activity
  • Application of flavonoid small molecule compound in preparing drug for inhibiting pancreatic lipase activity
  • Application of flavonoid small molecule compound in preparing drug for inhibiting pancreatic lipase activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Inhibitory effect of eriodictyol on pancreatic lipase detected by fluorescence spectrometry

[0020] Take 30 μL of 1 x 10 -3 mol L -1 Pancrelipase stock solution was mixed with 2970 μL PBS phosphate buffer solution, and then 3×10 -3 mol L -1 Mix 5 μL, 10 μL, 15 μL of eriodictyol mother solution, so that the concentration of eriodictyol solution in the mixed solution is 0.5×10 -5 , 1×10 -5 , 1.5×10 -5 mol L -1 , and reacted at 25°C for 3 minutes.

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Abstract

The invention belongs to the field of drugs or health care products, and particularly provides application of single use of a flavonoid small molecule compound or combination use of the flavonoid small molecule compound and other drugs in preparing a drug for inhibiting pancreatic lipase activity. The flavonoid small molecule compound is eriodictyol. The eriodictyol inhibits the absorption of triglyceride in food by inhibiting the pancreatic lipase activity, and has a better effect on preventing / treating obesity. The disclosed eriodictyol is derived from peanut shells, can better inhibit the pancreatic lipase activity, and provides a basis and reference for the development of drugs and health care products for preventing the obesity. Therefore, the disclosed natural substance eriodictyol as a lipid-lowering health care product has broad development prospects.

Description

technical field [0001] The invention relates to the application of eriodictyol in the preparation of drugs for inhibiting pancreatic lipase activity, especially the application in the prevention of obesity, and belongs to the technical field of research and development of medicines or health foods. Background technique [0002] As early as 1997, the World Health Organization declared obesity to be the world's leading health problem. Obesity can not only cause cardiovascular diseases such as diabetes, hypertension, dyslipidemia and coronary heart disease, but also cause some chronic diseases and even mental diseases, reducing the quality of life. Genetics, diseases, and excess energy can all lead to the occurrence of obesity, especially the intake of dietary fat is more likely to increase the risk of obesity. Therefore, controlling the intake or absorption of dietary fat can effectively control obesity. Food fat needs to be hydrolyzed by lipase before it can be absorbed. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/48A61K45/06A61P3/04A61K131/00
CPCA61K31/352A61K36/48A61K45/06A61P3/04
Inventor 刘剑利缪静宜孔宇驰刘悦曹怡阳张毓旸陈俊良仇萱纪月
Owner LIAONING UNIVERSITY
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