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Left-side stellate ganglion inhibitor based on near infrared laser illumination

A technology of laser irradiation and ganglion, applied in the field of medical application of nanomaterials, to achieve the effect of preventing and treating malignant ventricular arrhythmia, high dispersion and low biological toxicity

Pending Publication Date: 2019-09-24
SUZHOU INSTITUE OF WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies using the photothermal properties of gold nanorods to inhibit the left stellate ganglion

Method used

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  • Left-side stellate ganglion inhibitor based on near infrared laser illumination
  • Left-side stellate ganglion inhibitor based on near infrared laser illumination
  • Left-side stellate ganglion inhibitor based on near infrared laser illumination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Use silver ions to regulate the length of gold nanorods: follow the steps below

[0029] 1. Preparation of gold nano seed solution: add chloroauric acid solution (50 μL, 0.05M) into a glass bottle equipped with CTAB aqueous solution (10mL, 0.1M), and prepare 0.6mL ice water under magnetic stirring (1200rpm). 0.01M NaBH 4 Add the solution into the solution, continue to stir for 2 minutes until it turns brown, and store the seed solution at room temperature for 2 hours before using it.

[0030] 2. Growth of gold nanorods with different lengths: add chloroauric acid solution (200μL, 0.05M) into CTAB aqueous solution (20mL, 0.1M), prepare 6 groups in the same proportion, numbered 1, 2, 3, 4, 5, 6. Then add 40, 80, 120, 160, 200, 240 μL of silver nitrate solution (0.01M) to the 6 groups of solutions at a time and mix well, then add new L-ascorbic acid solution (160 μL, 0.1M ) to make growth fluid. After the obtained solutions were mixed, the color of the growth solution c...

Embodiment 2

[0032] The diameter of the gold nanorod is controlled by the amount of gold nano seed solution added, and the specific steps are as follows:

[0033]1. Preparation of gold nano seed solution: Add chloroauric acid solution (50 μL, 0.05M) into a glass bottle containing CTAB aqueous solution (10mL, 0.1M), and stir 0.6mL ice water under magnetic stirring (1200rpm) to prepare 0.01 M NaBH 4 Add it into the solution, continue to stir for 2 minutes until the solution turns brown, and store the seed solution at room temperature for 2 hours before using it.

[0034] 2. The growth of gold nanorods with different diameters: by mixing chloroauric acid solution (200 μL, 0.05M), silver nitrate solution (200 μL, 0.01M) and CTAB aqueous solution (20mL, 0.1M) in a glass tube, and then adding Freshly prepared L-ascorbic acid solution (160 μL, 0.1M) was used as a growth solution. After mixing the obtained solutions, the color of the growth solution changed from light yellow to colorless under m...

Embodiment 3

[0036] Precise preparation of gold nanorods with an absorption peak at 808nm, the specific steps are as follows:

[0037] 1. Preparation of gold nano seed solution: add chloroauric acid solution (50 μL, 0.05M) into a glass bottle containing CTAB aqueous solution (10mL, 0.1M), and 0.01 M NaBH 4 Add it into the solution, and continue to stir for 2 minutes until it turns brownish yellow to obtain a gold nanometer seed solution; store the gold nanometer seed solution at room temperature for 2 hours before using it.

[0038] 2. Growth of gold nanorods with different lengths: Add chloroauric acid solution (200 μL, 0.05M) into CTAB aqueous solution (20mL, 0.1M), add 200 μL of silver nitrate solution (0.01M) and mix well, then add Freshly prepared L-ascorbic acid solution (160 μL, 0.1M) was used as a growth solution. After mixing the obtained solutions, the color of the growth solution changed from light yellow to colorless under mild stirring conditions. Then, 400 μL of HCl (1.0 M...

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Abstract

The invention discloses a left-side stellate ganglion inhibitor based on near infrared laser illumination. By a hydrothermal method, the length of a nanogold rod is adjusted through adjusting the quantity of silver ions, the diameter of the nanogold rod is adjusted through adjusting the quantity of nanogold seed liquid, and the nanogold rod of which the longitudinal plasma absorption peak is near 808nm and which cooperates with the wave length of a near infrared laser is obtained through accurate control. The surface of the nanogold rod is modified with polyethylene glycol having thiol, so that the biotoxicity is reduced. The modified nanogold rod is injected into the left-side stellate ganglion, under the illumination of the near infrared laser of 808nm, the modified nanogold rod produces heat so that the temperature of the left-side stellate ganglion rises, the activity of the ganglion is restrained, and the function of the left-side stellate ganglion is reduced. The left-side stellate ganglion inhibitor provided by the invention hopefully reaches the purpose of preventing and treating ventricular arrhythmias.

Description

technical field [0001] The invention belongs to the medical application field of nanometer materials, and relates to a left stellate ganglion inhibitor based on near-infrared laser irradiation. Background technique [0002] Gold nanoparticles are recognized as promising nanomaterials due to their collective oscillation caused by electronic and optical interactions between the conduction bands. Localized surface plasmon resonance (LSPRS) is strongly affected by the structure, morphology, size, and surrounding medium of nanomaterials. The optoelectronic properties and physicochemical properties of gold nanoparticles depend not only on their size but also on their morphology, so controlling the morphology of gold nanoparticles becomes very important. Compared with spherical gold nanoparticles, gold nanorods are more adjustable and applicable. Due to their unique optical plasmonic properties, they are widely used in sensing, surface-enhanced Raman scattering (SERS), catalysis, ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P9/06B22F9/24B22F1/00B82Y40/00B82Y5/00
CPCA61K41/0052A61P9/06B22F9/24B82Y40/00B82Y5/00B22F1/054
Inventor 肖湘衡叶天宇余锂镭蒋昌忠
Owner SUZHOU INSTITUE OF WUHAN UNIV
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