Application of CBD as drug for treating METH addiction

A technology for addictive drugs and uses, applied in the direction of drug combinations, active ingredients of hydroxyl compounds, nervous system diseases, etc., can solve the problems of no effective drugs for drug addiction, drug abuse and unknown molecular mechanism of addiction, etc. achieve better therapeutic effects
CN110339185APending Publication Date: 2019-10-18KUNMING MEDICAL UNIVERSITY
0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KUNMING MEDICAL UNIVERSITY
Publication Date
2019-10-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to application of cannabidiol as a Sigma1R / AKT / GSK-3beta / CREB signal path inhibitor and as a drug for treating METH addiction. It is found that METH can induce rat CPP, CBD has an inhibitory effect on the METH addiction and phosphorylation of an AKT-GSK3beta-CREB signal path, the CBD can weaken the phenomenon that the METH induces the rat CPP by regulating a Sigma1R / AKT / GSK-3beta / CREB signal path after being in use in advance, and the therapeutic effect of the high-dose CBD (40, 80 mg / kg) is better. The application of the CBD is conductive to knowing the pharmacological effects of the CBD, provides new ways to treat the METH addiction, provides new theoretical guidance for drug abuse mechanism research and withdrawal therapy, and also provides new ideas and options for developing effective drugs for treating drug addiction.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of medicine, in particular to the use of CBD as a medicine for treating METH addiction, and the effect of CBD as a Sigma1R / AKT / GSK-3β / CREB signaling pathway inhibitor in reducing methamphetamine-induced CPP in rats. Background technique

[0002] Methamphetamine (METH) belongs to amphetamine stimulants, is a highly dependent psychoactive substance, is the most popular new synthetic drug in today's society, the appearance is white transparent irregular crystals, commonly known as "ice", its It has the characteristics of strong mental dependence, high relapse rate and high neurotoxicity. Long-term use can have significant toxic effects on the nervous system and cause serious physical and psychological damage to the abuser. Numerous studies have shown that the dopamine system, activation of microglia, neuronal apoptosis, and autophagy are involved in METH-induced neurotoxicity. But so far, the mechanism of METH-induced ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More