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A kind of preparation method of continuous production alpha-phenylethanol

A technology of phenylethanol and ethylbenzene, which is applied in the field of continuous production of α-phenylethanol, can solve the problem that ethylbenzene oxidation liquid cannot be directly hydrogenated, and achieve the effect of less separation steps, low energy consumption and high yield

Active Publication Date: 2021-07-23
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to obtain α-phenylethanol more efficiently and solve the problem that ethylbenzene oxidation liquid cannot be directly hydrogenated, this method aims to provide a method for hydrogenation using ethylbenzene oxidation liquid

Method used

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  • A kind of preparation method of continuous production alpha-phenylethanol
  • A kind of preparation method of continuous production alpha-phenylethanol
  • A kind of preparation method of continuous production alpha-phenylethanol

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Effect test

Embodiment 1

[0021] Such as figure 1 As shown, the solution containing cobalt ethylbenzene with a mass fraction of 0.1% isooctanoate enters the oxidation section, the oxidation temperature is 120°C, the oxygen pressure is 0.3MPa, and the residence time is 2h. The oxidized reaction solution is pumped to the esterification section , the mass of methanol added in the esterification section is 4 times the mass of the oxidation reaction solution, the esterification temperature is 220°C, the pressure is 1.5MPa, and the residence time is 1h. After the esterification is completed, the esterification reaction solution is pumped to the hydrogenation section. The hydrogenation catalyst is Ru / C (Ru mass content 5%wt) with 1% mass of the esterification liquid, the hydrogenation temperature is 110°C, the pressure is 1.0MPa, the residence time is 2h, and finally enters the rectification section through a pump , isolate the phenylethanol with a purity greater than 98%, and the separated methanol and unrea...

Embodiment 2-5

[0023] Repeat the reaction process and reaction conditions of Example 1, except that part of the reaction conditions is different, and the difference is as follows. The specific raw material reaction conditions and results of each embodiment are listed in Table 1.

[0024] Table 1

[0025]

[0026] The method takes α-phenylethanol as the target product. By introducing the esterification and acid removal section, the process of ethylbenzene oxidation is coupled with the process of hydrogenation of acetophenone to prepare phenylethanol, which reduces the traditional process and requires only one step of refining. Higher purity α-phenylethanol can be obtained through the distillation process, which has the advantages of low energy consumption and high yield.

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Abstract

The invention discloses a preparation method for continuous production of α-phenylethanol. The method uses ethylbenzene as a raw material, and obtains a mixed solution of acetophenone-phenylethanol through an oxidation section, and undergoes an acid removal process in an esterification section. A mixed solution of phenylethyl alcohol is obtained, and a phenylethyl alcohol product with a purity of more than 99.0% is obtained through rectification. The method takes α-phenylethanol as the target product. By introducing the esterification and acid removal section, the process of ethylbenzene oxidation is coupled with the process of hydrogenation of acetophenone to prepare phenylethanol, which reduces the traditional process and requires only one step of refining. Higher purity α-phenylethanol can be obtained through the distillation process, which has the advantages of low energy consumption and high yield.

Description

technical field [0001] The invention relates to the field of chemical engineering, in particular to a preparation method for continuous production of α-phenylethanol. Background technique [0002] α-Phenylethyl alcohol, also known as 1-phenylethyl alcohol, is one of the important chemical raw materials and is widely used in the perfume and pharmaceutical industries. For example, it is widely used in aroma blending in the perfume manufacturing industry, and as the main component of rose fragrance, it is used in the synthesis of various rose oils and essential oils. In many medicines, α-phenylethanol also has an important application. For example, in the synthesis of sedative drugs, α-phenylethanol is an important raw material. [0003] At present, the methods for producing α-phenylethanol are mainly natural extraction, microbial fermentation, chemical synthesis and other methods. The natural extraction method has limited raw materials and high cost; the fermentation method ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C29/50C07C29/149C07C29/145C07C33/22
CPCC07C29/145C07C29/149C07C29/50C07C45/36C07C67/08C07C49/78C07C33/22C07C69/614
Inventor 石松徐杰杜文强孙颖高进郑玺
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI