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Application of bile acid to preparation of metabolic disease drug

A technology for metabolic diseases and bile acids, which is applied in the application field of bile acids in the preparation of drugs for metabolic diseases, can solve the problems that the functions and mechanisms of bile acid components in regulating obesity and metabolism are poorly understood, etc. Effects of lipid metabolism, reducing obesity, and regulating intestinal flora

Active Publication Date: 2019-10-25
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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Problems solved by technology

However, the roles and mechanisms of bile acid components in regulating obesity and metabolism remain poorly understood

Method used

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  • Application of bile acid to preparation of metabolic disease drug
  • Application of bile acid to preparation of metabolic disease drug
  • Application of bile acid to preparation of metabolic disease drug

Examples

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Embodiment 1

[0018] 1. Animal Handling

[0019] 8-week-old, SPF-grade male C57BL / 6J mice were purchased from Beijing Lingchang Experimental Animal Co., Ltd., and were raised in SPF-grade IVC independent ventilation cages, 3 mice / cage, with a circadian rhythm of 12h-12h (7:00-19 :00 light, 19:00-7:00 dark); adequate food and water, free access to food. Mouse diet: standard commercial mouse common feed, containing 4.5% fat; 4% cellulose; 21% protein, 1.404kal / g. High fat feed (Research Diet), containing 60% fat, 20% carbohydrate, 20% protein, 5.243kcal / g. Feeds containing bile acids (DCA, GDCA and TDCA): respectively blended with high-fat feed at 0.5% by weight, and the control group was blended with PBS. After the mice were bred for 1 week to adapt to the environment, the experimental treatment was carried out. The entire animal experimental operation lasted for 4 weeks, and the body weight was weighed twice a week. After the experiment, the mouse feces were collected and immediately put ...

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Abstract

The invention relates to an application of bile acid to preparation of a metabolic disease drug. DCA (deoxycholic acid), GDCA (glycodeoxycholic acid) and TDCA (taurodeoxycholic acid) can increase basic metabolism rate by increasing the steatolysis and oxidation functions of white adipose tissues, in-vivo glycolipid metabolism is improved, intestinal flora are adjusted, high fat induced mouse obesity is relieved, and the application has great significance for clinically translational target spot search.

Description

technical field [0001] The invention belongs to the field of drugs for metabolic diseases, in particular to the application of bile acid in the preparation of drugs for metabolic diseases. Background technique [0002] Bile acids are a class of small molecular metabolites in the human body, named after they were first detected in bile. There are about 20 types of bile acids that can be detected and named in the human body, which are divided into primary bile acids and secondary bile acids according to the synthesis site. Primary bile acids are synthesized from cholesterol in the liver, including cholic acid (CA) and chenodeoxycholic acid (CDCA), which are catalyzed by cholesterol 7α-hydroxylase (CYP7A1) and cytochrome P450 (CYP8B1) in hepatocytes. The human body cannot synthesize secondary bile acids. This process depends on the role of intestinal flora. The microorganisms in the small intestine use bile salt hydrolase (BSH) to dissociate primary bile acids from bile salts,...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P3/00A61P3/04A61P3/10A61P1/16
CPCA61K31/575A61P3/00A61P3/04A61P3/10A61P1/16
Inventor 宁光王卫庆顾卫琼王计秋刘瑞欣洪洁
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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