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Phenethyl resorcinol microneedle patch and preparation method thereof

A technology of phenylethyl resorcinol and microneedle sticking, which is applied in the fields of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., and can solve the problem of low absorption and utilization efficiency of phenylethyl resorcinol, whitening and freckle-removing products Can not quickly penetrate into the bottom of the skin and other problems, to achieve the effect of easy to meet the preparation conditions, good whitening effect, and high safety

Inactive Publication Date: 2019-10-29
无锡元旭生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the deficiencies in the prior art, the present invention provides a phenylethyl resorcinol microneedle patch. The technical problem of low absorption and utilization efficiency, and the present invention also provides the preparation method of the above-mentioned phenylethyl resorcinol microneedle patch

Method used

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  • Phenethyl resorcinol microneedle patch and preparation method thereof
  • Phenethyl resorcinol microneedle patch and preparation method thereof
  • Phenethyl resorcinol microneedle patch and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0032] The preparation method of the instant phenylethylresorcinol microneedle patch is as follows:

[0033] Including the following steps:

[0034] S1, using silicon microneedles as a mould, through injection molding, drying and demolding, to obtain a microneedle master mold, the microneedle master mold is a polydimethylsiloxane master mold, and the microneedle master mold is provided with pinholes;

[0035] S21 Spread the needle tip preparation solution (the needle tip preparation solution is an aqueous solution containing 5% phenylethylresorcinol) onto the microneedle master mold in step S1, and adjust the air pressure to 0.1 atmosphere in a closed space, and keep The time is 10s, and the cycle is three times, so that the needle tip making liquid enters the pinhole;

[0036] S22, putting the microneedle master mold containing the needle tip preparation solution in step S21 into an air-drying oven to dry at a drying temperature of 50° C. to obtain the needle tip forming mic...

Embodiment 2

[0043] The preparation method of the slow-release phenylethyl resorcinol microneedle patch is as follows:

[0044] Including the following steps:

[0045] S1, using silicon microneedles as a mould, through injection molding, drying and demolding, to obtain a microneedle master mold, the microneedle master mold is a polytetrafluoroethylene master mold, and the microneedle master mold is provided with pinholes;

[0046] S2, spread the needle body solution (the needle body preparation solution is phenylethyl resorcinol, sodium hyaluronate with a molecular weight of 8000, divinyl sulfone, and water are mixed according to the ratio of 1:1:0.01:100 by weight percentage) Go to the microneedle master mold in step S1, adjust the air pressure to 5 atmospheres in a closed space, hold for 5 seconds, and cycle three times, so that the needle body on the microneedle master mold is filled with the needle body preparation liquid, and the liquid injection is obtained Microneedle Master.

[0...

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Abstract

The invention belongs to the field of microfabrication, and particularly relates to a phenethyl resorcinol microneedle patch. The patch comprises needles and a microneedle substrate, wherein the needles are uniformly distributed on the microneedle substrate, and the needles comprise phenethyl resorcinol with a content of 0.05-1.0% by weight percentage and sodium hyaluronate with a content of 10-50% by weight percentage. The invention also provides a preparation method of the phenethyl resorcinol microneedle patch. The phenethyl resorcinol microneedle patch provided by the invention adopts thephenethyl resorcinol, and the phenethyl resorcinol can be directly injected into the muscle bottom through a microneedle technology, so that the absorption efficiency of the skin on the phenethyl resorcinol is increased, and the whitening and freckle removing effects are doubled. In addition, the preparation method provided by the invention has the advantages that: the requirements of preparationconditions are easy to meet, and the production scale is easy to realize.

Description

technical field [0001] The invention belongs to the field of micro-manufacturing, and in particular relates to a phenylethylresorcinol microneedle patch and a preparation method thereof. Background technique [0002] With the development of society and the continuous improvement of people's living standards, consumers have higher and higher requirements for daily care products, and the requirements for product efficacy are becoming more and more detailed. Melanin is a protein that exists in the basal layer of everyone's skin. Ultraviolet radiation will change melanin and produce a substance that protects the skin. Then melanin moves through the layers of cell metabolism to the epidermis of the skin, forming our skin. Skin problems such as spots and uneven skin tone are now seen. [0003] Phenylethyl resorcinol is a safe, effective, and non-irritating whitening ingredient. Its ability to inhibit tyrosinase is 22 times that of kojic acid, and its ability to inhibit the synthe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/73A61K8/34A61Q19/02
CPCA61K8/0204A61K8/347A61K8/735A61K2800/782A61K2800/91A61Q19/02
Inventor 赵科研杨淑艳郭文平
Owner 无锡元旭生物技术有限公司
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