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A kind of manganese carbonate/polyamino acid compound and preparation method thereof

A polyamino acid and compound technology, applied in the field of manganese carbonate/polyamino acid compound and its preparation, can solve the problems of large manganese carbonate size, low purity, difficulty in conforming to biomedical applications, etc., and achieve convenient operation and simple preparation process , Realize the effect of drug release monitoring

Active Publication Date: 2021-11-23
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a manganese carbonate / polyamino acid complex and a preparation method thereof, aiming at solving the problem that the manganese carbonate prepared by the existing method has a large size or low purity, and is difficult to meet biological requirements. Questions about medical applications

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  • A kind of manganese carbonate/polyamino acid compound and preparation method thereof
  • A kind of manganese carbonate/polyamino acid compound and preparation method thereof
  • A kind of manganese carbonate/polyamino acid compound and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0048] (1) At room temperature, 1.980g MnCl 2 • 4H 2 O is dissolved in 10 mL of deionized water to form MnCl with a concentration of 1 mol / L 2 solution; 1.060g Na 2 CO 3 Dissolve in 100mL deionized water to form Na with a concentration of 0.1mol / L 2 CO 3 solution.

[0049] (2) Take 0.1mL, 1mol / L MnCl 2 The solution was added into 0.9mL Tris-HCl buffer (10mmol / L) and mixed evenly to obtain a manganese precursor solution; 0.1mL, 0.1mol / L Na 2 CO 3 The solution was mixed with 0.8 mL Tris-HCl buffer (10 mmol / L) to form a carbonate precursor solution.

[0050] (3) Take 0.1 mL of an aqueous solution containing 4 mg of polyethylene glycol-polyaspartic acid (the molecular weight of polyethylene glycol is 10,000, and the degree of polymerization of polyaspartic acid is 50) and mix it with the above-mentioned carbonate precursor solution , added to the above-mentioned manganese precursor solution, and stood in a refrigerator at 4°C for 12h.

[0051] (4) Then perform centrifuga...

Embodiment 2

[0053] (1) At room temperature, 1.980g MnCl 2 • 4H 2 O is dissolved in 10 mL of deionized water to form MnCl with a concentration of 1 mol / L 2 solution; 1.060g Na 2 CO 3 Dissolve in 100mL deionized water to form Na with a concentration of 0.1mol / L 2 CO 3 solution.

[0054] (2) Take 0.1mL, 1mol / L MnCl 2 The solution was added into 0.9mL Tris-HCl buffer (10mmol / L) and mixed evenly to obtain a manganese precursor solution; 0.1mL, 0.1mol / L Na 2 CO 3 The solution was mixed with 0.8 mL Tris-HCl buffer (10 mmol / L) to form a carbonate precursor solution.

[0055] (3) Take 0.1 mL of an aqueous solution containing 8 mg of polyethylene glycol-polyaspartic acid (the molecular weight of polyethylene glycol is 10,000, and the degree of polymerization of polyaspartic acid is 50) and mix it with the above-mentioned carbonate precursor solution , added to the above-mentioned manganese precursor solution, and stood in a refrigerator at 4°C for 12h.

[0056] (4) Then perform centrifuga...

Embodiment 3

[0058] (1) At room temperature, 1.980g MnCl 2 • 4H 2 O is dissolved in 10 mL of deionized water to form MnCl with a concentration of 1 mol / L 2 solution; 1.060g Na 2 CO 3 Dissolve in 100mL deionized water to form Na with a concentration of 0.1mol / L 2 CO 3 solution.

[0059] (2) Take 0.1mL, 1mol / L MnCl 2 The solution was added into 0.9mL Tris-HCl buffer (10mmol / L) and mixed evenly to obtain a manganese precursor solution; 0.1mL, 0.1mol / L Na 2 CO 3 The solution was mixed with 0.8 mL Tris-HCl buffer (10 mmol / L) to form a carbonate precursor solution.

[0060] (3) Take 0.1 mL of an aqueous solution containing 4 mg of polyethylene glycol-polyaspartic acid (the molecular weight of polyethylene glycol is 10,000, and the degree of polymerization of polyaspartic acid is 50) and mix it with the above-mentioned carbonate precursor solution , added to the above-mentioned manganese precursor solution, and stood in a 4°C refrigerator for 1h.

[0061] (4) Then perform centrifugation...

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Abstract

The invention discloses a manganese carbonate / polyamino acid compound and a preparation method thereof. The method comprises steps: A. mixing manganese salt or an aqueous solution of manganese salt with a Tris-HCl buffer to obtain a manganese precursor solution; mixing the carbonate Or the aqueous solution of carbonate, mixes with Tris-HCl buffer solution, obtains carbonate radical precursor solution; or, after mixing polyamino acid or polyamino acid aqueous solution with carbonate precursor solution, add manganese precursor solution to carry out static reaction; C, solid-liquid separation, washing, drying, to obtain manganese carbonate / polyamino acid Complex. The preparation method of the biomimetic mineralization of the invention is simple, convenient to operate, and does not require complex and expensive equipment; the prepared compound has good biocompatibility, biodegradability, and pH-responsive drug release characteristics.

Description

technical field [0001] The invention relates to the technical field of biological material preparation, in particular to a manganese carbonate / polyamino acid compound and a preparation method thereof. Background technique [0002] Manganese ion is an important magnetic resonance imaging contrast agent, and also one of the important trace elements in organisms. Therefore, manganese-containing materials such as manganese oxide and manganese carbonate have broad application prospects in biomedicine. Manganese carbonate has a pH-responsive solubility property, and its hydrolysis products are manganese ions and carbon dioxide gas. Among them, the manganese ions produced by hydrolysis can be used for magnetic resonance imaging, and the carbon dioxide gas produced can be excreted through the normal metabolism of the human body. Monitor treatment effects. [0003] At present, the application of manganese carbonate in biomedicine is relatively rare, the main reason is that the syn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L77/00C08K3/26
CPCC08K3/26C08L77/00
Inventor 黄鹏漆超付连花林静
Owner SHENZHEN UNIV
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