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Injection containing bone marrow mesenchymal stem cells

A technology of stem cells and injections, applied in the field of stem cells, can solve the problems of uncontrollable disease of patients, high risk of transplantation treatment, and restriction of wide application, and achieve the effect of enhancing non-specific immune function, promoting paracrine effect, and having no toxic side effects.

Inactive Publication Date: 2019-11-08
杨慧慧
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to autoimmune diseases, there are still some patients whose condition cannot be controlled after autologous HSCT, and some cases relapse after operation. In addition, the risk of transplantation treatment is high, and the related mortality rate is about 7%, which is higher than that of non-autoimmune diseases (3%). wide application of the technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The injection containing bone marrow mesenchymal stem cells is mainly composed of serum, Ringer's solution, glucose, glycine, selenized astragalus polysaccharide, lentinan and bone marrow mesenchymal stem cells.

[0037] Among them, each 1L of serum contains the following components:

[0038] Ringer's solution 40mL

[0039] Glucose 8g

[0040] Glycine 7.5g

[0041] Selenized Astragalus Polysaccharide 3.5g

[0042] Lentinan 4.5g

[0043] Bone marrow mesenchymal stem cells 7g.

[0044] Wherein, Ringer's solution is the mixed solution that contains sodium chloride, potassium chloride and calcium chloride, and the described Ringer's solution of every 100mL contains sodium chloride 850mg, sodium chloride 30mg, calcium chloride 33mg.

[0045] Among them, the preparation method of selenized astragalus polysaccharide is as follows: take 5.5kg of type II astragalus polysaccharide and add it to 55mL of dehydrated pyridine, stir with a magnetic stirrer, stir for 12.5min, and ...

Embodiment 2

[0050] The injection containing bone marrow mesenchymal stem cells is mainly composed of serum, Ringer's solution, glucose, glycine, selenized astragalus polysaccharide, lentinan and bone marrow mesenchymal stem cells.

[0051] Among them, each 1L of serum contains the following components:

[0052] Ringer's solution 30mL

[0053] Glucose 6g

[0054] Glycine 5g

[0055] Selenized Astragalus Polysaccharide 2g

[0056] Lentinan 3g

[0057] Bone marrow mesenchymal stem cells 5g.

[0058] Wherein, Ringer's solution is the mixed solution that contains sodium chloride, potassium chloride and calcium chloride, and the described Ringer's solution of every 100mL contains sodium chloride 850mg, sodium chloride 30mg, calcium chloride 33mg.

[0059] Among them, the preparation method of selenized astragalus polysaccharide is as follows: take 5 kg of type II astragalus polysaccharide and add it to 50 mL of dehydrated pyridine, stir with a magnetic stirrer, stir for 10 min, and then dr...

Embodiment 3

[0064] The injection containing bone marrow mesenchymal stem cells is mainly composed of serum, Ringer's solution, glucose, glycine, selenized astragalus polysaccharide, lentinan and bone marrow mesenchymal stem cells.

[0065] Among them, each 1L of serum contains the following components:

[0066] Ringer's solution 50mL

[0067] Glucose 10g

[0068] Glycine 10g

[0069] Selenized Astragalus Polysaccharide 5g

[0070] Lentinan 6g

[0071] Bone marrow mesenchymal stem cells 9g.

[0072] Wherein, Ringer's solution is the mixed solution that contains sodium chloride, potassium chloride and calcium chloride, and the described Ringer's solution of every 100mL contains sodium chloride 850mg, sodium chloride 30mg, calcium chloride 33mg.

[0073] Among them, the preparation method of selenized astragalus polysaccharide is as follows: take 6 kg of type II astragalus polysaccharide and add it to 60 mL of dehydrated pyridine, stir with a magnetic stirrer, stir for 15 min, and then ...

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PUM

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Abstract

The invention provides an injection containing bone marrow mesenchymal stem cells. The injection containing the bone marrow mesenchymal stem cells is mainly prepared by mixing serum, a ringer's solution, glucose, glycine, selenylation astragalus polysaccharide, lentinan and the bone marrow mesenchymal stem cells, has no toxic side effects and is good in safety. The injection has sodium and potassium elements needed for the body due to the presence of ringer's solution. The glycine can remove free radicals in the body and promote the paracrine effect of stem cell secretory factors. The selenylation astragalus polysaccharide and the lentinan can prolong the duration of continuous action of the stem cell secretory factors and enhance a non-specific immune function of the body.

Description

technical field [0001] The invention relates to the technical field of stem cells, in particular to an injection containing bone marrow mesenchymal stem cells. Background technique [0002] 1. Bone marrow mesenchymal stem cell function [0003] Bone marrow contains two completely different stem cells: hematopoietic stem cells and mesenchymal stem cells (MSCs), the former maintains hematopoiesis, while the latter constitutes the microenvironment of bone marrow hematopoiesis. These two independent and completely different stem cells not only co-exist but also cooperate with each other in function to complete the reconstruction of the blood system in the adult body. In addition to bone marrow, there are also a small amount of MSCs in other tissues, but the bone marrow is the most abundant in adults, accounting for about 0.001-0.01% of nucleated cells, so bone marrow is a more suitable source of MSCs. [0004] In 1970, Friedenstein proved the existence of MSCs in vitro through...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K9/08A61P37/02A61P19/02A61P21/00A61P7/06A61P29/00A61P17/00A61P1/16A61P19/04A61K33/14A61K31/198A61K31/715
CPCA61K9/0019A61K9/08A61K31/198A61K31/715A61K33/14A61K35/28A61P1/16A61P7/06A61P17/00A61P19/02A61P19/04A61P21/00A61P29/00A61P37/02A61K2300/00
Inventor 杨慧慧
Owner 杨慧慧
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