Application of Ganoderma lucidum spore powder polysaccharides to preparation of functional foodstuffs with auxiliary colon cancer inhibiting effect

A technology of Ganoderma lucidum spore powder and polysaccharide, applied in the field of polysaccharides, can solve problems such as damage to normal cells, and achieve the effects of low cost, simple, stable and high-efficiency process, and good colon cancer tumors.

Inactive Publication Date: 2019-11-08
ZHEJIANG WANSHOUKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Malignant tumors are currently a serious disease that endangers human health. Chemotherapy is one of the main methods used in the systemic treatment of malignant tumors. However, most anti-tumor chemical drugs also seriously damage normal cells while killing tumor cells. Therefore, looking for Anticancer drugs with high efficiency and low toxicity are of great significance

Method used

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  • Application of Ganoderma lucidum spore powder polysaccharides to preparation of functional foodstuffs with auxiliary colon cancer inhibiting effect
  • Application of Ganoderma lucidum spore powder polysaccharides to preparation of functional foodstuffs with auxiliary colon cancer inhibiting effect
  • Application of Ganoderma lucidum spore powder polysaccharides to preparation of functional foodstuffs with auxiliary colon cancer inhibiting effect

Examples

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Comparison scheme
Effect test

Embodiment 1

[0032] The polysaccharide of Ganoderma lucidum spore powder in this embodiment is prepared by the following method: take the raw material of Ganoderma lucidum spore powder and extract it with boiling water. For the first extraction, the amount of water used is 20 times the total mass of the raw material, boiled for 5 hours and filtered; When extracting, the amount of water used is 20 times the total mass of raw materials, boiled for 3 hours and filtered; for the third extraction, the amount of water used is 10 times the total mass of raw materials, boiled for 2 hours and filtered, combined filtrates, vacuum concentrated to about 1 / 10. The concentrated solution is subjected to trichloroacetic acid protein removal treatment, and 30% trichloroacetic acid (mass percentage) of the same volume is added. After the treatment time is 4 hours, it is neutralized with 10% NaOH (mass percentage), and after neutralization, the reaction solution is placed in Dialysis in a dialysis bag. Duri...

Embodiment 2

[0034] The polysaccharide of Ganoderma lucidum spore powder in this example is prepared by the following method: take the raw material of Ganoderma lucidum spore powder and extract it with boiling water. When extracting for the first time, the amount of water used is 15 times the total mass of the raw material of Ganoderma lucidum spore powder, boil for 5 hours and filter; During the second extraction, the consumption of water is 15 times of the total mass of the raw material of Ganoderma lucidum spore powder, boil for 3 hours and filter; during the third extraction, the consumption of water is 10 times of the total mass of the raw material of Ganoderma lucidum spore powder, boil for 3 hours and filter, and combine the filtrates , concentrated in vacuo. The concentrated solution is subjected to trichloroacetic acid protein removal treatment, and 25% trichloroacetic acid (mass percentage) of the same volume is added. After the treatment time is 3 hours, it is neutralized with 10...

Embodiment 3

[0036] The polysaccharide of Ganoderma lucidum spore powder in this example is prepared by the following method: take the raw material of Ganoderma lucidum spore powder and extract it with boiling water. When extracting for the first time, the amount of water used is 10 times the total mass of the raw material of Ganoderma lucidum spore powder, boil for 3 hours and filter; During the second extraction, the consumption of water is 20 times of the total mass of the raw material of ganoderma lucidum spore powder, boiled for 3 hours and filtered; during the third extraction, the consumption of water is 10 times of the total mass of the raw material of ganoderma spore powder, boiled for 5 hours and filtered, and the filtrates are combined , concentrated in vacuo, the concentrated solution was carried out trichloroacetic acid protein removal treatment, added 15% trichloroacetic acid (mass percentage) of the same volume, after the treatment time was 5h, neutralized with 10% NaOH (mass ...

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Abstract

The invention discloses the application of Ganoderma lucidum spore powder polysaccharides to preparation of functional foodstuffs with auxiliary colon cancer inhibiting effect. The Ganoderma lucidum spore powder polysaccharides of the invention are prepared from Ganoderma lucidum spore powder through procedures including extraction with boiling water, deproteinization, dialysis and ethanol treatment. The Ganoderma lucidum spore powder polysaccharides have the function of regulating a tumor microenvironment. The ganoderma lucidum spore powder polysaccharides in the invention have high purity and activity, can regulate the tumor microenvironment by inhibiting tumor neovascularization and inhibiting the growth of colon cancer fibroblasts, and show good auxiliary colon cancer inhibiting effect. The preparation method for the Ganoderma lucidum spore powder polysaccharides in the invention is simple, stable and efficient in process, suitable for industrial production and low in cost.

Description

technical field [0001] The invention belongs to the technical field of polysaccharides, and in particular relates to the application of ganoderma lucidum spore powder polysaccharides in the preparation of functional foods with the effect of assisting in inhibiting colon cancer. Background technique [0002] Malignant tumors are currently a serious disease that endangers human health. Chemotherapy is one of the main methods used in the systemic treatment of malignant tumors. However, most anti-tumor chemical drugs also seriously damage normal cells while killing tumor cells. Therefore, looking for Anticancer drugs with high efficiency and low toxicity are of great significance. In recent years, studies have found that polysaccharides have significant anti-tumor activity and have relatively small toxic and side effects on the human body. The research on the biological activity of polysaccharides has become a hot spot for experts and scholars at home and abroad in the medical f...

Claims

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Application Information

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IPC IPC(8): C08B37/00A23L33/125A23L31/00A61P35/00A61P37/06A61P39/06
CPCA23V2002/00A23L31/00A23L33/125A61P35/00A61P37/06A61P39/06C08B37/0003A23V2200/308A23V2200/30A23V2250/51
Inventor 金美艳陈喜良
Owner ZHEJIANG WANSHOUKANG PHARMA CO LTD
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