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Molecularly imprinted polymer material and its preparation and application in the detection of adrenaline

A technology of polymer materials and molecular imprinting, which is applied in the direction of analysis materials, luminescent materials, material excitation analysis, etc., to achieve the effect of obvious fluorescence effect, high sensitivity and obvious selective detection effect

Active Publication Date: 2022-06-07
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, epinephrine is mostly used as imprinted molecule for electrochemical sensors, and few methods utilize GQDs for fluorescence detection of epinephrine.

Method used

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  • Molecularly imprinted polymer material and its preparation and application in the detection of adrenaline
  • Molecularly imprinted polymer material and its preparation and application in the detection of adrenaline
  • Molecularly imprinted polymer material and its preparation and application in the detection of adrenaline

Examples

Experimental program
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Effect test

Embodiment 1

[0040] (1) Prepare the graphene quantum dots with uniform dispersion and particle size, and the specific steps are as follows:

[0041] (1), the citric acid is pyrolyzed at 200 ℃ until the color becomes pale yellow liquid;

[0042] (2), dissolving (1) into 10 mg / mL sodium hydroxide, stirring continuously, and obtaining graphene quantum dots after dialysis.

[0043] figure 1 TEM of the graphene quantum dots prepared in Example 1. It can be seen from the figure that the particle size of the prepared graphene quantum dots is about 5-8 nm.

[0044] (2) the preparation method of polypyrrole comprises the steps:

[0045] (1.1), add hydrogen peroxide solution to a mixture of 1 mL of pyrrole, 0.1 g of ferrous chloride and 94 mL of deionized water, mix and stir for 6 h.

[0046] (1.2), washing the solution prepared in (2.1) with water 3 times, and vacuum drying at room temperature to obtain polypyrrole;

[0047] (3) Preparation of molecularly imprinted polymers:

[0048] (2.1), in ...

Embodiment 2

[0064] A preparation method of molecularly imprinted polymer material, comprising the following steps:

[0065] (1) Preparation of graphene quantum dots with uniform dispersion and uniform particle size:

[0066] (1.1) Pyrolyze citric acid at 180-200°C until the color becomes pale yellow liquid;

[0067] (1.2) Disperse the pale yellow liquid obtained in step (1.1) into sodium hydroxide solution, stir continuously, and obtain graphene quantum dots after dialysis. The concentration of the sodium hydroxide solution is 5 mg / mL, and the molar ratio of the citric acid to the sodium hydroxide is 1:2; the molecular weight of the dialysis bag used in the dialysis described in step (1.2) is 3000-3500 Da.

[0068] (2) adding the graphene quantum dots and epinephrine obtained in step (1) during the polymerization of pyrrole into polypyrrole, stirring continuously, washing with acid for 3 to 5 times to remove the template molecule epinephrine, and then washing with water for 3 to 5 times ...

Embodiment 3

[0076] A preparation method of molecularly imprinted polymer material, comprising the following steps:

[0077] (1) Preparation of graphene quantum dots with uniform dispersion and uniform particle size:

[0078] (1.1) Pyrolyze citric acid at 260-270°C until the color becomes pale yellow liquid;

[0079] (1.2) Disperse the pale yellow liquid obtained in step (1.1) into sodium hydroxide solution, stir continuously, and obtain graphene quantum dots after dialysis. The concentration of the sodium hydroxide solution is 15 mg / mL, and the molar ratio of the citric acid to the sodium hydroxide is 1:3; the molecular weight of the dialysis bag used in the dialysis described in step (1.2) is 3000-3500 Da.

[0080] (2) adding the graphene quantum dots and epinephrine obtained in step (1) during the polymerization of pyrrole into polypyrrole, stirring continuously, washing with acid for 3 to 5 times to remove the template molecule epinephrine, and then washing with water for 3 to 5 times...

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Abstract

The invention relates to a molecularly imprinted polymer material and its preparation and application in detecting adrenaline. The material uses polypyrrole-modified graphene quantum dots with adrenaline as a template molecule, and has a structural formula of ppy / GQDs@MIPs. The preparation method comprises the following steps: (1) preparing graphene quantum dots with uniform dispersion and uniform particle size; (2) adding the graphene quantum dots obtained in step (1) and adrenaline during the polymerization of pyrrole into polypyrrole, and continuously stirring washing with acid for 3 to 5 times to remove the template molecule adrenaline, and then washing with water for 3 to 5 times; preparing a molecularly imprinted polymer nanomaterial of polypyrrole-modified graphene quantum dots using adrenaline as a template molecule. Compared with the prior art, the material of the invention has the advantages of high selectivity and strong sensitivity, and the material itself has low toxicity, and has good detection effect at the cell level.

Description

technical field [0001] The invention belongs to the technical field of nanometer detection, in particular to the preparation of a molecularly imprinted polymer material and its application in detecting epinephrine. Background technique [0002] Carbon is the most magical element in nature, and its performance in the nano world is equally astonishing. [0003] Quantum dots are interesting nanomaterials in which the movement of electrons in all directions is restricted, so the quantum confinement effect is significant. Graphene quantum dots (GQDs), as a new type of carbon-based nanomaterials, have attracted much attention due to their unique properties and advantages. Some properties, such as low toxicity, good fluorescence properties, chemical inertness, excellent photostability as well as biocompatibility, tunable photoluminescence properties, make them suitable for various biological and chemical applications. The research of graphene quantum dots mainly focuses on the ch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64C09K11/02C09K11/65
CPCG01N21/6428C09K11/025C09K11/65G01N2021/6432
Inventor 吴惠霞张恬刘冶坪肖虹宇杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
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